Vitreous Seeding From Retinal Astrocytoma in Three Cases

Cohen, Victoria M L; Shields, Carol L.; Furuta, Minoru; Shields, Jerry A.

doi:10.1097/iae.0b013e3181669781

Cited by 28 publications

(15 citation statements)

References 19 publications

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“…Seeding of tumor cells is a characteristic feature of retinoblastoma. It can, however, be observed in other primary intra-ocular tumoral conditions such as melanocytoma of the optic nerve (Shields et al, 2006c), ciliary body medulloepithelioma (Kaliki et al, 2013a), retinal astrocytoma (Cohen et al, 2008), and uveal melanoma (Metz et al, 2016).…”

Section: Intra-ocular Seedingmentioning

confidence: 99%

Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. “Alive, with good vision and no comorbidity”

Munier

Beck‐Popovic

Chantada

et al. 2019

Progress in Retinal and Eye Research

163

157

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Retinoblastoma is lethal by metastasis if left untreated, so the primary goal of therapy is to preserve life, with ocular survival, visual preservation and quality of life as secondary aims. Historically, enucleation was the first successful therapeutic approach to decrease mortality, followed over 100 years ago by the first eye salvage attempts with radiotherapy. This led to the empiric delineation of a window for conservative management subject to a "state of metastatic grace" never to be violated. Over the last two decades, conservative management of retinoblastoma witnessed an impressive acceleration of improvements, culminating in two major paradigm shifts in therapeutic strategy. Firstly, the introduction of systemic chemotherapy and focal treatments in the late 1990s enabled radiotherapy to be progressively abandoned. Around 10 years later, the advent of chemotherapy in situ, with the capitalization of new routes of targeted drug delivery, namely intra-arterial, intravitreal and now intracameral injections, allowed significant increase in eye preservation rate, definitive eradication of radiotherapy and reduction of systemic chemotherapy. Here we intend to review the relevant knowledge susceptible to improve the conservative management of retinoblastoma in compliance with the "state of metastatic grace", with particular attention to (i) reviewing how new imaging modalities impact the frontiers of conservative management, (ii) dissecting retinoblastoma genesis, growth patterns, and intraocular routes of tumor propagation, (iii) assessing major therapeutic changes and trends, (iv) proposing a classification of relapsing retinoblastoma, (v) examining treatable/preventable disease-related or treatment-induced complications, and (vi) appraising new therapeutic targets and concepts, as well as liquid biopsy potentiality.

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Section: Intra-ocular Seedingmentioning

confidence: 99%

Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. “Alive, with good vision and no comorbidity”

Munier

Beck‐Popovic

Chantada

et al. 2019

Progress in Retinal and Eye Research

163

157

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“…Related rare entities such as presumed solitary circumscribed retinal astrocytic proliferation [18,19,20] have clinical appearance of a white circumscribed, retinal lesion without prominent retinal vascularity in absence of associated subretinal fluid or hemorrhage and may be included within the spectrum of reactive retinal astrocytic tumors as well as acquired astrocytomas (not associated with tuberous sclerosis) that are composed of astrocytes lacking mitotic figures [21,22]. …”

Section: Discussionmentioning

confidence: 99%

Reactive Retinal Astrocytic Tumor (Focal Nodular Gliosis): Report of the Clinical Spectrum of 3 Cases

et al. 2017

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Purpose: To report 3 cases providing insight into clinical progression of reactive retinal astrocytic tumor. Methods: The clinical, imaging, and when available, the cytologic features of 3 cases of reactive retinal astrocytic tumor (focal nodular gliosis) were reviewed. Results: A 6-year-old female, a 49-year-old man, and a 39-year-old man each developed a white retinal mass associated with laser photocoagulation, lattice degeneration, and treatment of a presumed vascular tumor, respectively. All tumors were white, circumscribed retinal masses that tended to be associated with exudation and either initially or eventually minimal vascularity. Conclusion: Reactive retinal astrocytic tumor can be observed in response to a degenerative, inflammatory, or ischemic retinal insult. Such tumors may progress after therapeutic intervention.

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“…Die Differenzialdiagnose zu einem bilateralen Retinoblastom kann schwierig sein, weil andere charakteristische Symptome eines TSC wie Café-au-Lait-Flecken der Haut und ein Adenoma sebaceum des Gesichts erst im späteren Lebensalter auftreten. Die Tatsache, dass astrozytäre Hamartome auch eine Glaskörperaussaat aufweisen können [47], erschwert die Differenzialdiagnose weiter. Nur sehr selten kommt es zu einem progressiven Tumorwachstum mit Konversion der Hamartome in aggressiv wachsende Riesenzellastrozytome der Netzhaut [48].…”

Section: Klinik Diagnostikunclassified

Tumoren und Pseudotumoren der Netzhaut und des Ziliarepithels

Biewald¹,

Schlüter²,

Kiefer³

et al. 2020

Augenheilkunde up2date

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ZusammenfassungDie Varietät retinaler Tumoren reicht von harmlosen Läsionen über benigne, lokal destruierende Tumoren bis hin zu lebensbedrohlichen Erkrankungen. Nicht immer lassen sie sich einfach voneinander unterscheiden. Die Diagnose sollte nach Möglichkeit klinisch gestellt werden wegen der Gefahr einer Tumorzellverschleppung durch invasive Diagnostik. Jedoch rückt die genetische Charakterisierung der Läsion immer mehr in den Vordergrund. Je nach Entität ist eine Therapie in einem spezialisierten Zentrum notwendig.

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Vitreous Seeding From Retinal Astrocytoma in Three Cases

Abstract: Retinal astrocytoma can produce vitreous seeds, sometimes associated with tumor growth. Care should be taken to exclude the diagnosis of retinoblastoma.

Cited by 28 publications

References 19 publications

Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. “Alive, with good vision and no comorbidity”

Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. “Alive, with good vision and no comorbidity”

Reactive Retinal Astrocytic Tumor (Focal Nodular Gliosis): Report of the Clinical Spectrum of 3 Cases

Tumoren und Pseudotumoren der Netzhaut und des Ziliarepithels

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