Vivax malaria in Mauritania includes infection of a Duffy-negative individual

Wurtz, Nathalie; Lekweiry, Khadijetou Mint; Bogreau, Hervé; Pradines, Bruno; Rogier, Christophe; Boukhary, Ali Ould Mohamed Salem; Hafid, Jamal; Salem, Mohamed Salem Ould Ahmedou; Trape, Jean‐François; Basco, Léonardo K.; Briolant, Sébastien

doi:10.1186/1475-2875-10-336

Cited by 99 publications

(103 citation statements)

References 60 publications

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“…Malaria has also been found in Angola and Equatorial Guinea in Duffy negative individuals [24]. P. vivax malaria has also been detected in Duffy antigen negative individuals in Mauritania [25]. Similar infections have been reported in Brazil [26] and Kenya [23].…”

Section: Discussionsupporting

confidence: 52%

Duffy Red Cell Phenotypes among Pregnant Women in Sokoto, North Western Nigeria

Erhabor¹,

Ce²,

Alhaji³

et al. 2014

J Blood Disord Transfus

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Section: Discussionsupporting

confidence: 52%

Duffy Red Cell Phenotypes among Pregnant Women in Sokoto, North Western Nigeria

Erhabor¹,

Ce²,

Alhaji³

et al. 2014

J Blood Disord Transfus

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“…This was because of the assumption that Duffy negative individuals, found in high frequencies on the continent (Howes et al, 2011), are refractory to P. vivax infection. This supposition was incorporated into the model, despite observations of P. vivax malaria infections in Duffy-negative individuals in Madagascar ( Menard et al, 2010) and on the mainland of the continent (Ryan et al, 2006;Mendes et al, 2011;Wurtz et al, 2011). While this information contradicts our working assumption of complete protection, there is insufficient evidence to determine if these are more than just rare occurrences on the continent that would have a significant effect on the epidemiology of P. vivax in Africa.…”

Section: Africa+mentioning

confidence: 73%

The Global Public Health Significance of Plasmodium vivax

Battle

Gething

Elyazar

et al. 2012

Advances in Parasitology

113

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“…Recently, Duffy-null individuals were found to be infected with P. vivax, both throughout Africa (Kenya, Madagascar, Mauritania, Cameroon, Angola, Equatorial Guinea, Ethiopia, and Sudan) and in South America (12)(13)(14)(15)(16)(17)(18)(19)(20)(21), raising the question: How can P. vivax invade in the absence of Duffy blood group expression? Is it possible that mutations in the cysteine-rich region 2 of the P. vivax DBP1 allows binding to another protein on the surface of Duffy-null erythrocytes, unrelated to the Duffy?…”

Section: Dna Expansionmentioning

confidence: 99%

Role of Plasmodium vivax Duffy-binding protein 1 in invasion of Duffy-null Africans

Gunalan

Hostetler

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

121

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The ability of the malaria parasite Plasmodium vivax to invade erythrocytes is dependent on the expression of the Duffy blood group antigen on erythrocytes. Consequently, Africans who are null for the Duffy antigen are not susceptible to P. vivax infections. Recently, P. vivax infections in Duffy-null Africans have been documented, raising the possibility that P. vivax, a virulent pathogen in other parts of the world, may expand malarial disease in Africa. P. vivax binds the Duffy blood group antigen through its Duffy-binding protein 1 (DBP1). To determine if mutations in DBP1 resulted in the ability of P. vivax to bind Duffy-null erythrocytes, we analyzed P. vivax parasites obtained from two Duffy-null individuals living in Ethiopia where Duffy-null and -positive Africans live side-by-side. We determined that, although the DBP1s from these parasites contained unique sequences, they failed to bind Duffy-null erythrocytes, indicating that mutations in DBP1 did not account for the ability of P. vivax to infect Duffy-null Africans. However, an unusual DNA expansion of DBP1 (three and eight copies) in the two Duffy-null P. vivax infections suggests that an expansion of DBP1 may have been selected to allow low-affinity binding to another receptor on Duffy-null erythrocytes. Indeed, we show that Salvador (Sal) I P. vivax infects Squirrel monkeys independently of DBP1 binding to Squirrel monkey erythrocytes. We conclude that P. vivax Sal I and perhaps P. vivax in Duffy-null patients may have adapted to use new ligand-receptor pairs for invasion.Plasmodium vivax | Duffy blood group antigen | Duffy-binding protein | DNA expansionI n 1975 we identified the failure of Plasmodium knowlesi to invade Duffy-null erythrocytes (1). We assumed that the Duffy blood group null phenotype, a common African phenotype, conferred resistance in Africans to P. vivax, a Plasmodium closely related to P. knowlesi. Subsequent studies demonstrated that African American volunteers who were Duffy-null were resistant to mosquito-transmitted P. vivax (2). In addition, African American soldiers in Vietnam who were infected with P. vivax were all Duffypositive (3). Furthermore, African Americans in a village in Honduras who were infected with P. vivax were all Duffy-positive whereas those infected with P. falciparum were both Duffy-null and -positive (4). We concluded that Duffy null was the basis of resistance to P. vivax by Africans.The molecular basis of Duffy null was a single point mutation in the GATA1-binding sequence in the promotor region 5′ to the Duffy blood group ORF (Fig. 1B) that led to Duffy-blood-groupnull erythrocytes (5). In vitro studies with P. knowlesi demonstrated that the invasive merozoites were able to bind and reorient apically with Duffy-null erythrocytes but could not form a junction as occurred in Duffy-positive erythrocytes, indicating that the Duffy blood group was required for P. vivax invasion (6). Later, in P. knowlesi parasite culture supernatants, the parasite ligand binding to Duffy blood group antigen was identi...

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Vivax malaria in Mauritania includes infection of a Duffy-negative individual

Cited by 99 publications

References 60 publications

Duffy Red Cell Phenotypes among Pregnant Women in Sokoto, North Western Nigeria

Duffy Red Cell Phenotypes among Pregnant Women in Sokoto, North Western Nigeria

The Global Public Health Significance of Plasmodium vivax

Role of Plasmodium vivax Duffy-binding protein 1 in invasion of Duffy-null Africans

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