VLSI-enabled DNA sequencing arrays

Abstract

Massively-parallel, integrated, sensitive and low-cost bio-molecular detectors are an essential part of "next generation" DNA sequencing systems. This paper discusses various design methodologies that leverage the versatility of VLSI technologies, specifically CMOS fabrication processes, to build highly integrated sequencing arrays while addressing the stringent detection and integration requirements. The goal of this paper is to discuss both the advantages and the limitations of next generation VLSI-enabled DNA sequencers.

VLSI Structures for DNA Sequencing—A Survey

“…Although the ASIC SOC was used to control and read out an array of nanopore sensors [ 17 ], they were able to utilize the advantages of CMOS technology and became successful in the DNA sequencing industry with a highly portable device. The detailed advantages and implementations of VLSI-enabled sequencing detection are reviewed in [ 18 ].…”