VMP35 MNC, a novel iron-free supplement, enhances cytoprotection against anemia in human subjects: a novel hypothesis

Abstract

Background The American Society of Hematology reported that according to the National Heart, Lung, and Blood Institute (NHLBI) anemia is the most common blood disorder, which affects more than 3 million Americans, while the Global Burden of Disease 2016 (GBD 2016) reported that iron deficiency anemia (IDA) is the leading cause of anemia, which affects 1.93 billion people worldwide. Anemia is intricately linked to chronic inflammation, chronic kidney disease, gastrointestinal and gynecological malignancies, and autoimmune disorders. Hemorrhagic anemia results in substantial loss of blood, which causes significant alterations in all blood parameters, including reduced iron. The other type of anemia is chronic anemia syndrome (CAS), which is a constellation of disorders and chronic inflammatory events caused by an increasing anaerobic/acidic environment (promoting the growth of anaerobic organisms), inducing a defensive expenditure of alkalinizing buffers in hemoglobin (i.e. histidine), to prevent a dangerous lowering of blood pH. In this process, iron is cleaved from heme groups and transferred out of blood circulation into other organs, like the liver, appearing to be IDA, where excessive accumulation can lead to hemochromatosis, also known as ‘iron overload anemia’. Design A pilot clinical study was conducted in 38 subjects (men = 10; women = 28; age = 22–82 years) to evaluate the rate of absorption and effects on blood of VMP35 multi-nutrient complex (MNC), a non-iron containing liquid nutraceutical supplement. Subjects consumed either placebo or VMP35 (30 mL) over a period of 0, 5, or 30 min. Methods Changes in peripheral blood smears from 38 subjects were observed using live blood cell imaging (LBCI) with phase contrast microscopy. Adverse events were rigorously monitored. Results VMP35 caused positive changes in the blood, including morphological, hematological (including restoration of hemoglobin), and rheological changes following 5 min of administration, which were sustained for at least 30 min. Conclusion Overall, the non-iron containing VMP35 can induce improvements in blood properties and potential benefits for subjects even with compromised digestive systems. No adverse events were reported. Further research studies are in progress to explore the mechanistic insight.

An Iron-Free VMP35 Multi-nutrient Complex Modulates an Array of Homeostatic Biological Parameters: Promoting Hemoglobinization, Aerobic Metabolism, Viral Immuno-competence, and Inflammatory Regulation

“…Innate immune cells, including dendritic cells, stimulate T-cells through antigens, while adaptive immune cells stimulate innate immune cells through T-helper cell-mediated interferon gamma (IFN-γ)[<link rid="bib28">28</link>, <link rid="bib29">29</link>], which in turn activates the dendritic cell subsets and the macrophages. Innate immunity serves as the rst line of defense, while the integral components of adaptive immunity mobilize slowly and consistently [3,4,28,29]. Ultimately, the shared mediators merge innate and adaptive immune function as an integral part of the composite immune system [2,3].…”

“…Acute in ammation exhibits primarily ve characteristic signs including pain, swelling, heat, redness and loss of function or immobility. In ammation is intended to be a natural down-stream part of the healing process and only becomes problematic if prolonged and/or excessive [2][3][4]. As indicated, the duration of in ammatory events is inversely related to the constitutional strength and oxygenating potential of the a icted tissue and/or the duration and intensity of the injurious source/cause, such as an infectious virus, bacteria, etc.…”

“…In the third step, a proprietary combination of research-driven structurally diverse antioxidants, multivitamins, micronutrients, minerals, and standardized botanical phytonutrients are carefully, sequentially, and progressively introduced and thoroughly blended in a high-shear wet milling treatment to create a nano-emulsion. 4. The nal step involves the extensive blending of the nano-emulsion and ion-enhanced PC to achieve the Prodosomed encapsulation technology, which produces this patent-pending multi-lamellar energetically enhanced clustoidal 'Prodosomal'…”

“…The authors' proposal is that the most prevalent form of iron de ciency anemia, including 'anemia of chronic disease', is not caused by an iron de ciency [1]. While in ammation and chronic kidney disorders are common symptomatic conditions appearing to result during the anemia, they are a consequence of the etiology of the anemic pathology [2][3][4]. Low iron and Red Blood Cell (RBC) properties, the evidence of anemia, are the result of a proli c expenditure of alkalinizing histidine molecules from heme protein to maintain blood pH in the critical and optimal life-support zone [1].…”

A novel strategy for processing, production and quality control of an iron-free nutraceutical supplement that rapidly restores iron-dependent hemoglobin in red blood cells

“…Occurrence of anemia is greatly associated with low iron function in available transferrin, the glycoproteins that bind to and consequently mediate iron transportation through blood plasma for normal physiological functions (Iron deficiency anemia 2018; Corbier et al 2019). Three main storage tissues for ferritin iron are gut, macrophages, and hepatic tissues.…”