VO(acac)2: An Efficient Catalyst for the Oxidation of Aldehydes to the Corresponding Acids in the Presence of Aqueous H2O2

Abstract

VO(acac) 2 catalyzes the oxidation of aldehydes (aromatic, aliphatic, and heterocyclic) to the corresponding acids efficiently and selectively in the presence of H 2 O 2 as an oxidant. This method possesses functional-group compatibility, easy workup procedure, and shorter reaction time. The reaction is highly dependent on the solvent used. Performance of titania-supported VO(acac) 2 in the oxidation of aldehyde was also investigated.

A biocatalytic method for the chemoselective aerobic oxidation of aldehydes to carboxylic acids

“…In fact, a number of catalytic organic and metal-organic reagents are not applicable for the oxidation of these substrates because of the need for medium-high boiling solvents for the reaction, which complicates product isolation, or lack of activity. 12,19,36 In the case of medium and long chain aldehydes from six to ten carbon atoms (6-12a), the ALDHs could oxidise the substrates with analytical yields ranging from 54% to 94%. A general trend was not revealed as the best performing ALDH depended on the particular substrate.…”

“…tert-BuOOH, H 2 O 2 , H 5 IO 6 ) or dioxygen. [14][15][16][17][18][19][20][21][22][23] This second generation of methods provided some improvements in terms of chemoselectivity, relatively simple reaction procedures and complementary substrate scope (e.g. depending on the method of choice and related mechanism, substituted aromatic aldehydes bearing either electron donating or electro withdrawing substituents can be converted with high yields).…”

Design, Synthesis, and Applications of a Vanadium Complex: An Effective Catalyst for the Direct Conversion of Alcohols and Aldehydes to Esters

“…In addition, they represent the most adaptable carrier moieties that can be utilized as carrier-linked prodrugs of hydroxyl and carboxy functionalities in the pharmaceutical field . The major implementation ways of achieving these esters are nucleophilic substitution of alcohols with carbonyl moieties such as carboxylic acid, acyl chlorides, and anhydrides, the Baeyer–Villiger oxidation of ketones, and direct oxidation of aldehydes and alcohols to esters by 3d metal catalysts (Scheme ). Recently, transition metal- and photoredox-catalyzed alkoxy-carbonylation of alkenes has emerged as an alternative and appealing approach for ester synthesis .…”

Efficient and selective oxidation of aldehydes with dioxygen catalysed by vanadium-containing heteropolyanions

“…Other groups have also recently reported the oxidation of aromatic aldehydes to the corresponding carboxylic acids by aqueous H 2 O 2 catalysed by VO(acac) 2 [35] or H 5 PV 2 Mo 10 O 40 [36]. Nevertheless, from an industrial point of view the use of oxovanadium together with H 2 O 2 is highly dangerous as the reaction is exothermic and, in some cases, it becomes explosive.…”