Vocal Fold Paralysis after Esophagectomy for Carcinoma

Loochtan, Michael J.; Balcarcel, Daniel; Carroll, Elizabeth; Foecking, Eileen M.; Thorpe, Eric; Charous, Steven J.

doi:10.1177/0194599816644738

Cited by 7 publications

(11 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings were confirmed in more recent studies, all demonstrating an increase in pulmonary complications after esophagectomy complicated by RLNP (9,10,20,24). Similarly to our results, Koyanagi et al (10) found an association between RLNP and prolonged hospital stay.…”

Section: Discussionsupporting

confidence: 93%

“…The results of this study regarding short-term complications after RLN injury during esophagectomy are in line with current literature (9,10,20,23,24). The first study published on this topic found higher rates of pulmonary complications after RLNP, leading to a higher reintubation rate, and consequently a prolonged ventilation time and longer ICU stay (23).…”

Section: Discussionsupporting

confidence: 87%

“…For 6/21 of these patients surgical intervention (medialization thyroplasty) was required. All treatment interventions for vocal cord paralysis were conducted after a median time of 16.5 [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] months after esophagectomy. Of all patients that underwent medialization thyreoplasty, 3/6 had no more RLNP symptoms afterwards 2/6 made a partial recovery from their RLNP, and 1/6 did not recover.…”

Section: Functional Outcomesmentioning

confidence: 99%

“…Patients with RLNP may present with symptoms ranging from hoarseness, dyspnea during speech, aspiration, difficulty with coughing, marked morbidity through pulmonary complications [pneumonia, acute respiratory distress syndrome (ARDS), atelectasis], and may even suffocate in case of bilateral damage. Only few retrospective studies have reported on the consequences of RLNP on the short term, particularly the incidence of pulmonary complications (8)(9)(10)19,23,24). Furthermore, information on the long term (i.e., recovery and possible surgical interventions) is lacking.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Recurrent laryngeal nerve injury after esophagectomy for esophageal cancer: incidence, management, and impact on short- and long-term outcomes

Scholtemeijer¹,

Seesing²,

Brenkman³

et al. 2017

J. Thorac. Dis.

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 87%

Section: Functional Outcomesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Recurrent laryngeal nerve injury after esophagectomy for esophageal cancer: incidence, management, and impact on short- and long-term outcomes

Scholtemeijer¹,

Seesing²,

Brenkman³

et al. 2017

J. Thorac. Dis.

View full text Add to dashboard Cite

show abstract

“…We mostly attribute this to the small sample size in this study. As VFP after esophagectomy occurs only in around 24% of patients, we were not able to discern this statistically with only a few patients in each group [21]. In our study population, surgery was performed for the treatment of EC and not for the treatment of ERF.…”

Section: Discussionmentioning

confidence: 86%

Vocal Fold Paralysis is a Common Complication in Esophageal Cancer Patients with Esophagorespiratory Fistula

Paul

Echterdiek

Bohle

et al. 2020

JGLD

View full text Add to dashboard Cite

Background and Aims: The development of an esophagorespiratory fistula (ERF) in patients with esophageal cancer (EC) is associated with poor prognosis. We observed a high rate of vocal fold paralysis (VFP) in patients with ERF. Data on prevalence and complications of VFP in ERF are lacking. The present study investigated the incidence of VFP in patients with malignant ERF and examined possible risk factors and the impact on survival. Methods: We performed a retrospective case-control study of 46 institutional cases of EC patients with ERF in a time period of eleven years. Patients were matched to 92 randomly selected controls (EC patients without ERF) in a 1:2 fashion for tumor localization and histology. Demographics, clinical characteristics, recurrence, treatment modalities as well as survival were analyzed. Results: Esophageal cancer patients with ERF developed more often VFP than EC patients without ERF (59% vs. 21%; p=0.02; odds ratio (OR) 4.9). Esophageal cancer patients with ERF had a more pronounced weight loss (7.1 vs. 11.5 kg; P = 0.008), as well as higher rates of esophageal (p=<0.001; OR 22.9) and tracheal stenting (p=<0.001; OR 76.8). Proximal tumor growth (p=0.004; OR 7.9), fistula formation to the trachea (p=<0.001; OR 17.2) and recurrent disease (p=0.04, OR 4.7) was associated with VFP development in EC patients with ERF. Vocal fold paralysis in ERF did not adversely affect five-year survival. Conclusions: Vocal fold paralysis is a common complication in more than half of the patients with ERF in EC. It is associated with proximal tumor growth, fistula formation to the trachea and disease recurrence, but does not influence survival.

show abstract

Incidence and Outcomes of Laryngeal Complications Following Adult Cardiac Surgery: A National Analysis

et al. 2021

View full text Add to dashboard Cite

Laryngeal complications (LCs) following cardiac operations contribute to increased morbidity and resource utilization. Using a nationally representative cohort of cardiac surgical patients, we characterized the incidence of LC as well as its associated clinical and financial outcomes. All adults undergoing coronary artery bypass grafting and/or valvular operations were identified using the 2010–2017 Nationwide Readmissions Database. International Classification of Diseases 9th and 10th Revision diagnosis codes were used to identify LC. Trends were analyzed using a rank-based, non-parametric test (nptrend). Multivariable linear and logistic regressions were used to evaluate risk factors for LC, and its impact on mortality, complications, resource use and 30-day non-elective readmissions. Of an estimated 2,319,628 patients, 1.7% were diagnosed with perioperative LC, with rising incidence from 1.5% in 2010 to 1.8% in 2017 (nptrend < 0.001). After adjustment, female sex [adjusted odds ratio 1.08, 95% confidence interval (CI) 1.04–1.12], advancing age, and multi-valve procedures (1.51, 95% CI 1.36–1.67, reference: isolated CABG) were associated with increased odds of LC. Despite no risk-adjusted effect on mortality, LC was associated with increased odds of pneumonia (2.88, 95% CI 2.72–3.04), tracheostomy (4.84, 95% CI 4.44–5.26), and readmission (1.32, 95% CI 1.26–1.39). In addition, LC was associated with a 7.7-day increment (95% CI 7.4–8.0) in hospitalization duration and $24,200 (95% CI 23,000–25,400) in attributable costs. The present study found LC to be associated with increased perioperative sequelae and resource utilization. The development and application of active screening protocols for post-surgical LC are warranted to increase early detection and reduce associated morbidity.

show abstract

Vocal Fold Paralysis after Esophagectomy for Carcinoma

Cited by 7 publications

References 14 publications

Recurrent laryngeal nerve injury after esophagectomy for esophageal cancer: incidence, management, and impact on short- and long-term outcomes

Recurrent laryngeal nerve injury after esophagectomy for esophageal cancer: incidence, management, and impact on short- and long-term outcomes

Vocal Fold Paralysis is a Common Complication in Esophageal Cancer Patients with Esophagorespiratory Fistula

Incidence and Outcomes of Laryngeal Complications Following Adult Cardiac Surgery: A National Analysis

Contact Info

Product

Resources

About