Voice Range Change After Injection Laryngoplasty for Unilateral Vocal Fold Paralysis

Pei, Yu‐Cheng; Chuang, Hsiu-Feng; Chang, Chia-Fen; Chang, Tzu-Ling; Chiang, Hui-Chen; Fang, Tuan‐Jen

doi:10.1016/j.jvoice.2017.07.019

Cited by 8 publications

(1 citation statement)

References 31 publications

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“…Interestingly, despite the lack of functional contraction on LAP, MEE pigs on average had higher measurements in the majority of studied voice parameters (Supplemental Figure 4), supporting a mild vocal fold augmentation (bulking) effect of the MEEs, as would be expected with injecting non-trophic MPCs. 54 Given the promising microenvironmental changes yet lack of statistically significant functional results after MEE injections, longer timepoints may be necessary to study the full regenerative capacity of MEE cells.…”

Section: Functional Analysismentioning

confidence: 99%

Early Changes in Porcine Larynges Following Injection of Motor‐Endplate Expressing Muscle Cells for the Treatment of Unilateral Vocal Fold Paralysis

et al. 2023

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ObjectivesNo curative injectable therapy exists for unilateral vocal fold paralysis. Herein, we explore the early implications of muscle‐derived motor‐endplate expressing cells (MEEs) for injectable vocal fold medialization after recurrent laryngeal nerve (RLN) injury.MethodsYucatan minipigs underwent right RLN transection (without repair) and muscle biopsies. Autologous muscle progenitor cells were isolated, cultured, differentiated, and induced to form MEEs. Three weeks after the injury, MEEs or saline were injected into the paralyzed right vocal fold. Outcomes including evoked laryngeal electromyography (LEMG), laryngeal adductor pressure, and acoustic vocalization data were analyzed up to 7 weeks post‐injury. Harvested porcine larynges were examined for volume, gene expression, and histology.ResultsMEE injections were tolerated well, with all pigs demonstrating continued weight gain. Blinded analysis of videolaryngoscopy post‐injection revealed infraglottic fullness, and no inflammatory changes. Four weeks after injection, LEMG revealed on average higher right distal RLN activity retention in MEE pigs. MEE‐injected pigs on average had vocalization durations, frequencies, and intensities higher than saline pigs. Post‐mortem, the MEE‐injected larynges revealed statistically greater volume on quantitative 3D ultrasound, and statistically increased expression of neurotrophic factors (BDNF, NGF, NTF3, NTF4, NTN1) on quantitative PCR.ConclusionsMinimally invasive MEE injection appears to establish an early molecular and microenvironmental framework to encourage innate RLN regeneration. Longer follow‐up is needed to determine if early findings will translate into functional contraction.Level of EvidenceNA Laryngoscope, 2023

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Section: Functional Analysismentioning

confidence: 99%