Volatile compound profile and essential oil composition of three wild Algerian aromatic plants with their antioxidant and antibiofilm activities

Djebili, Samah; Taş, Meltem; Bouguerra, Ali; Küçükaydın, Selçuk; Ceylan, Özgür; Duru, Mehmet Emin; Barkat, Malika

doi:10.1007/s11694-021-01220-1

Cited by 4 publications

(3 citation statements)

References 54 publications

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“…The order of biofilm inhibition against the tested bacteria was revealed as T. algeriensis > O. glandulosum > E. globulus EOs. The T. algeriensis EO showed the highest inhibition against L. monocytogenes (80.95%), and E. coli (77.83%) at MICs [ 168 ]. Some other biofilm inhibiting plant extracts and essential oils are listed in Table 6 .…”

Section: Biofilm Controlling Compoundsmentioning

confidence: 99%

Natural Strategies as Potential Weapons against Bacterial Biofilms

Asma

Imre

Morar

et al. 2022

Life

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Microbial biofilm is an aggregation of microbial species that are either attached to surfaces or organized into an extracellular matrix. Microbes in the form of biofilms are highly resistant to several antimicrobials compared to planktonic microbial cells. Their resistance developing ability is one of the major root causes of antibiotic resistance in health sectors. Therefore, effective antibiofilm compounds are required to treat biofilm-associated health issues. The awareness of biofilm properties, formation, and resistance mechanisms facilitate researchers to design and develop combating strategies. This review highlights biofilm formation, composition, major stability parameters, resistance mechanisms, pathogenicity, combating strategies, and effective biofilm-controlling compounds. The naturally derived products, particularly plants, have demonstrated significant medicinal properties, producing them a practical approach for controlling biofilm-producing microbes. Despite providing effective antibiofilm activities, the plant-derived antimicrobial compounds may face the limitations of less bioavailability and low concentration of bioactive molecules. The microbes-derived and the phytonanotechnology-based antibiofilm compounds are emerging as an effective approach to inhibit and eliminate the biofilm-producing microbes.

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Section: Biofilm Controlling Compoundsmentioning

confidence: 99%

Natural Strategies as Potential Weapons against Bacterial Biofilms

Asma

Imre

Morar

et al. 2022

Life

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“…16 Eucalyptus globulus containing p-cym as one of its chief constituents inhibited approximately 27% biofilm of C. albicans at around 1 μL mL −1 concentration. 17 The previous studies revealed that extensive efforts have been made to examine the antimicrobial efficacy of crude essential oils. These oils consist of an array of phytochemicals such as pcymene, eucalyptol, cinnamaldehyde, eugenol, α-pinene, globulol, α-terpinol, etc.…”

Section: Introductionmentioning

confidence: 99%

“…Eucalyptus globulus containing p -cym as one of its chief constituents inhibited approximately 27% biofilm of C. albicans at around 1 μL mL –1 concentration . The previous studies revealed that extensive efforts have been made to examine the antimicrobial efficacy of crude essential oils.…”

Section: Introductionmentioning

confidence: 99%

Exploration of Antibiofilm and In Vivo Wound Healing Activity of p-Cymene-Loaded Gellan/PVA Nanofibers

Mishra

Gupta

Srivastava³

et al. 2023

ACS Appl. Bio Mater.

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Wound dressings with outstanding biocompatibility, antimicrobial, and tissue regeneration activities are essential to manage emerging recalcitrant antifungal infections to speed up healing. In this study, we have engineered p-cymene-loaded gellan/PVA nanofibers using electrospinning. Morphological and physicochemical properties of the nanofibers were characterized using a multitude of techniques to validate the successful integration of p-cymene (p-cym). The fabricated nanomaterials exhibited strong antibiofilm activity against Candida albicans and Candida glabrata compared to pure p-cymene. In vitro biocompatibility assay demonstrated that nanofibers did not possess any cytotoxicity to the NIH3T3 cell lines. In vivo, full-thickness excision wound healing study showed that the nanofibers were able to heal skin lesions faster than the conventional clotrimazole gel in 24 days without forming any scar. These findings unraveled p-cymene-loaded gellan gum (GA)/poly(vinyl alcohol) (PVA) nanofibers as an effective biomaterial for cutaneous tissue regeneration.

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Isolation and Characterization of Compounds from Truffle Melanogaster broomenaus and their Bioactivities

Şavkıncı,

Taş Küçükaydın,

Kuş

et al. 2024

Chemistry & Biodiversity

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Melanogaster broomeanus Berk. is a type of truffle common in pine, oak, and hazelnut forests and which naturally spreads in the Black Sea, Mediterranean, South‐West Anatolia in Turkey, is consumed as food and traded. Chemical investigation of M. broomenaus led to isolate of ten known compounds namely, brassicasterol (1), ergosterol (2), ergosterol peroxide (3), 5α, 6α‐epoxy ergosta‐7,22‐diene‐3β‐ol (4), trametenolic acid (5), maleic acid (6), fumaric acid (7), mannitol (8), kojibiose (9) and trehalose (10). Assessments of the antioxidant, anticholinesterase, anti‐urease, and cytotoxic properties of extracts and isolated compounds were carried out. Compound 5 showed the highest cytotoxic activity against H‐1299 with IC50: 23.78±0.98 μg/mL, while compound 2 demonstrated most potent cytotoxicity against MCF‐7 with IC50: 30.91±0.15 μg/ml. Also, compound 5 showed the highest antioxidant activity in all methods, particularly in DPPH and ABTS assays with IC50 values of 90.24±0.87, 75.41±0.10 µg/mL, respectively. Similarly, compound 5 exhibited highest activity with 38.84±1.22% and 44.58±0.96% inhibitions against AChE and BChE, respectively, while compound 7 were found to be most potent inhibitory against urease with value of 55.20±0.45% at 100 µg/mL concentration. These findings suggest that M. broomenaus, like numerous other edible mushrooms, is a steroid‐rich truffle and a potential source of steroids.

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Volatile compound profile and essential oil composition of three wild Algerian aromatic plants with their antioxidant and antibiofilm activities

Cited by 4 publications

References 54 publications

Natural Strategies as Potential Weapons against Bacterial Biofilms

Natural Strategies as Potential Weapons against Bacterial Biofilms

Exploration of Antibiofilm and In Vivo Wound Healing Activity of p-Cymene-Loaded Gellan/PVA Nanofibers

Isolation and Characterization of Compounds from Truffle Melanogaster broomenaus and their Bioactivities

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