Volatile Constituents of<i>Vitex negundo</i>Leaves

Singh, Virendra; Dayal, R.; Bartley, Jim

doi:10.1055/s-2006-960832

Cited by 50 publications

(21 citation statements)

References 2 publications

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“…belongs to the family Verbenaceae, a large family of herbs, lianas, shrubs, or trees comprising about 36 genera and 1035 species and is indigenous to the Mediterranean countries and central Asia, and also found in parts of Pakistan, India and Burma [1,2].…”

Section: Introductionmentioning

confidence: 99%

α-Chymotrypsin inhibition studies on the lignans from Vitex negundo Linn

Lodhi

Choudhary²,

Malik

et al. 2008

Journal of Enzyme Inhibition and Medicinal Chemistry

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Section: Introductionmentioning

confidence: 99%

α-Chymotrypsin inhibition studies on the lignans from Vitex negundo Linn

Lodhi

Choudhary²,

Malik

et al. 2008

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…Supplementation with antioxidant such as vitamin E has been reported to be useful in the prevention of alcoholinduced neural disorders (Agar et al, 2003). The leaves of V. negundo have been reported to possess flavonoids, alkaloids, terpenoids and tannins (Singh et al, 1999). These phytochemical constituents are reported to possess antioxidant properties and have shown to be potent inhibitors of lipid peroxidation.…”

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confidence: 99%

Protective effect of the leaves of Vitex negundo against ethanol-induced cerebral oxidative stress in rats

Umamaheswari

Asokkumar

Umamageswari

et al. 2012

Tanzania J Hlth Res

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The present study investigated the effect of the various fractions of hydromethanolic extract of the leaves of Vitex negundo (Verbenaceae) against ethanol-induced cerebral oxidative stress in rats. Cerebral oxidative stress was induced by the administration of 20% ethanol (5 ml/100gbw) for a period of 28 days. The petroleum ether (PEF), chloroform (CF), ethylacetate (EAF) and residual (RF) fractions at a dose of 200 mg/kgbw orally were simultaneously administered with ethanol for 28 days. α-tocopherol at a dose of 100 mg/kg orally was used as the standard. Administration of ethanol resulted in a significant elevation in serum biochemical parameters like aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), uric acid, triglycerides and lipoprotein levels. In addition there was a significant (P<0.01) elevation in malondialdehyde (MDA) and lipid hydroperoxide (LH) levels and a significant (P<0.01) reduction in enzymatic and non-enzymatic antioxidants in the brain tissue. Histopathological examination of the brain tissue of the ethanol treated animals showed marked gliosis. Simultaneous administration of the fractions prevented the enzymatic leakage and elevation of serum uric acid, triglycerides and lipoprotein levels. All the fractions (except the residual fraction) prevented the rise in lipid peroxidation and enhanced the antioxidant enzymes. Further, histopathological examination revealed that the fractions of V. negundo offered a significant protection against ethanol toxicity in rat brain. The activity exhibited by the chloroform fraction is comparable to that of the standard. The present study reveals that the leaf of V. negundo has protective action on the brain, which could be attributed to its antioxidant potential. __________________________________________________________________________________________

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“…This plant is native to many countries including Zanzibar, Mozambique, Madagascar and Sri Lanka. The chemical constituents of leaves of V. negundo include flavonoids, nishindine, 1-sabinene, 1-α-pinene, viridiflorol, beta-caryophyllene, 4-terpineol, gamma-terpinene, caryophyllene oxide and sesquiterpenes including copaene (Singh et al, 1999;Jayaweera, 1982). Gautam et al (2008) have carried out a phytochemical investigation of the methanolic extract of leaves of V. negundo to identify the major chemical constituents, that is, negundoside, agnuside, vitegnoside, 7,8 dimethyl herbacetin 3-rhamnoside, 5,3'-dihydroxy-7,8,4'-trimethoxy flavanone, 5-hydroxy-3,6,7,3',4'-pentamethoxy flavone, 5,7 dihydroxy-6,4' dimethoxy flavonone and 5 hydroxy-7,4' dimethoxy flavones.…”

Section: Introductionmentioning

confidence: 99%

Anti-candidal activity of Piper betle (L.), Vitex negundo (L.) and Jasminum grandiflorum (L.)

H.¹,

M.²,

Gehan³

et al. 2014

Afr. J. Microbiol. Res.

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The discovery of antimicrobials from traditional medicinal plants is gaining importance. The objectives of this study were to determine the anti-candidal activity of young and mature leaves of Piper betle collected from dry and wet zones of Sri Lanka, leaves and roots of Vitex negundo and leaves of Jasminum grandiflorum and the determination of minimum inhibitory concentrations (MIC). Water and ethanolic extracts of plant material were tested against standard cultures of Candida albicans, Candida glabrata, Candida krusei, Candida parapsilosis and Candida tropicalis. The MICs of active extracts were determined. Ethanolic extracts of young leaves of P. betle showed significantly higher (p < 0.05) anticandidal activity against all Candida species bioassayed, while mature leaves showed less activity. MICs of ethanolic extract of young leaves of P. betle were within 0.64 -3.2 mg/mL. There was no significant difference between the activity of leaves of P. betle collected from wet zone and dry zone (p > 0.05). Water extracts of leaves of P. betle and water and ethanolic extracts of leaves and roots of V. negundo and leaves of J. grandiflorum did not show a significant anti-candidal activity. Hence, young leaves of P. betle can be used as an anti-candidal agent since betel leaves are used in masticatory mixtures.

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Volatile Constituents ofVitex negundoLeaves

Cited by 50 publications

References 2 publications

α-Chymotrypsin inhibition studies on the lignans from Vitex negundo Linn

α-Chymotrypsin inhibition studies on the lignans from Vitex negundo Linn

Protective effect of the leaves of Vitex negundo against ethanol-induced cerebral oxidative stress in rats

Anti-candidal activity of Piper betle (L.), Vitex negundo (L.) and Jasminum grandiflorum (L.)

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