Volatile constituents of the fruit of <i>Garcinia atroviridis</i> and their antibacterial and anti‐inflammatory activities

Tan, Wen-Nee; Wong, K. C.; Khairuddean, Melati; Eldeen, I.M.S.; Asmawi, Mohd Zaini; Sulaiman, Baharuddin

doi:10.1002/ffj.3118

Cited by 18 publications

(9 citation statements)

References 108 publications

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“…Phytochemical studies on G. atroviridis have reported the presence of garcinia acid (hydroxycitric acid) and its lactone, atroviridin, atrovirisidone and atrovirinone as well as some organic acid and volatile constituents besides flavonoids or phenolic compounds . Hydroxycitric acid is the principal acid of fruit rinds of G. cambogia , G. indica and G. atroviridis .…”

Section: Resultsmentioning

confidence: 99%

Effect of extraction solvents and plant parts used on the antihyperlipidemic and antioxidant effects ofGarcinia atroviridis: a comparative study

2013

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Aqueous and methanol extracts of G. atroviridis showed higher antihyperlipidemic and antioxidant effects, respectively. Total phenolic and flavonoid contents showed significant correlations with antioxidant but not with antihyperlipidemic activities, indicating the involvement of other compounds. Contrary to the traditional belief, the present findings suggest that the fruit has higher antihyperlipidemic potential than the fruit rind.

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Section: Resultsmentioning

confidence: 99%

Effect of extraction solvents and plant parts used on the antihyperlipidemic and antioxidant effects ofGarcinia atroviridis: a comparative study

2013

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“…The fruits, leaves, and stem bark extracts of G. atroviridis are found to be a rich source of bioactive secondary metabolites, including phenolic, flavonoid and tannin compounds such as xanthones (atroviridin), benzoquinones (atrovirinone), cambogin, garcinol, camboginal, triflavanone (garcineflavanone A) and biflavonols (garcineflavonol A) [ 20 , 21 , 22 ]. These phytochemicals have been reported to display diverse pharmacological activities including antioxidant [ 22 , 23 ], antimicrobial [ 23 , 24 ], anti-proliferative [ 17 , 23 , 25 ], anti-inflammatory [ 24 ], anti-cholinesterases [ 21 ] and anti-hyperlipidemic effects [ 20 ]. Interestingly, it has been reported that some of these phytometabolites such as phenolic compounds, were capable to transform inorganic silver ions into nanoparticles [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

A Bottom-Up Synthesis Approach to Silver Nanoparticles Induces Anti-Proliferative and Apoptotic Activities Against MCF-7, MCF-7/TAMR-1 and MCF-10A Human Breast Cell Lines

et al. 2020

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A bottom-up approach for synthesizing silver nanoparticles (AgNPs-GA) phytomediated by Garcinia atroviridis leaf extract is described. Under optimized conditions, the AgNPs-GA were synthesized at a concentration of 0.1 M silver salt and 10% (w/v) leaf extract, 1:4 mixing ratio of reactants, pH 3, temperature 32 °C and 72 h reaction time. The AgNPs-GA were characterized by various analytical techniques and their size was determined to be 5–30 nm. FTIR spectroscopy indicates the role of phenolic functional groups in the reduction of silver ions into AgNPs-GA and in supporting their subsequent stability. The UV-Visible spectrum showed an absorption peak at 450 nm which reflects the surface plasmon resonance (SPR) of AgNPs-GA and further supports the stability of these biosynthesized nanoparticles. SEM, TEM and XRD diffractogram analyses indicate that AgNPs-GA were spherical and face-centered-cubic in shape. This study also describes the efficacy of biosynthesized AgNPs-GA as anti-proliferative agent against human breast cancer cell lines, MCF-7 and MCF-7/TAMR-1. Our findings indicate that AgNPs-GA possess significant anti-proliferative effects against both the MCF-7 and MCF-7/TAMR-1 cell lines, with inhibitory concentration at 50% (IC50 values) of 2.0 and 34.0 µg/mL, respectively, after 72 h of treatment. An induction of apoptosis was evidenced by flow cytometry using Annexin V-FITC and propidium iodide staining. Therefore, AgNPs-GA exhibited its anti-proliferative activity via apoptosis on MCF-7 and MCF-7/TAMR-1 breast cancer cells in vitro. Taken together, the leaf extract from Garcinia atroviridis was found to be highly capable of producing AgNPs-GA with favourable physicochemical and biological properties.

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“…Meanwhile, (E)-β-farnesene (58.5%) and β-caryophyllene (16.9%) were dominated in the leaf EO. The stem bark EO composed mainly palmitoleic acid (51.9%), followed by palmitic acid (21.9%), and 3-methoxy-5-pentylphenol (5.5%) (8,9).…”

Section: Essential Oilsmentioning

confidence: 99%

“…The fruit EO of G. atroviridis was active towards Bacillus subtilis and Staphylococcus aureus with minimum inhibitory concentration (MIC) of 4.8 mg/mL. Meanwhile, it showed weak activity on Escherichia coli, Pseudomonas stutzeri and Salmonella typhimurium (8). Regarding the leaf EO of G. celebica, it showed better inhibition on B. subtilis and MRSA than Proteus mirabilis.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Essential Oils of Garcinia spp. and Their Biological Activities

Tan,

Azizi,

Che Omar

et al. 2023

MJMHS

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Garcinia is the largest genus in the Clusiaceae family. Plants of Garcinia are widely distributed in Africa, Asia, Australia, Central America, Madagascar, and Polynesia. There are over 400 species of Garcinia found in the lowland tropical forests. Garcinia are known for their medicinal values due to the presence of biologically active constituents. Plants with medicinal values play a key role in human health and disease prevention. Plant-based natural products such as essential oils (EOs) have been employed for centuries owing to their beneficial effects. Generally, EOs are a mixture of volatile chemical constituents comprising mainly terpenoids and phenylpropanoids. They play diverse roles as biologically active agents. To date, EOs have found wide applications in pharmaceutical, food, flavour and fragrance. This review discusses the volatile chemical constituents of EOs extracted from different plant parts of Garcinia. The biological activities of Garcinia EOs are highlighted to explore their therapeutic potential.

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Volatile constituents of the fruit of Garcinia atroviridis and their antibacterial and anti‐inflammatory activities

Cited by 18 publications

References 108 publications

Effect of extraction solvents and plant parts used on the antihyperlipidemic and antioxidant effects ofGarcinia atroviridis: a comparative study

Effect of extraction solvents and plant parts used on the antihyperlipidemic and antioxidant effects ofGarcinia atroviridis: a comparative study

A Bottom-Up Synthesis Approach to Silver Nanoparticles Induces Anti-Proliferative and Apoptotic Activities Against MCF-7, MCF-7/TAMR-1 and MCF-10A Human Breast Cell Lines

Essential Oils of Garcinia spp. and Their Biological Activities

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