Voltammetric Behavior of Bilirubin Based on [bmim][PF6] As the Supporting Electrolyte in Organic Solvent and Its Analytical Application

Ye, Jian; Xiong, Huayu; Wang, Qi; Zhang, Xun; Wang, Shengfu

doi:10.5099/aj110300191

Cited by 8 publications

(4 citation statements)

References 20 publications

(27 reference statements)

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“…The electrocatalytic oxidation of BR and the following oxidation reactions are irreversible by nature as described in Equations (2)–(4) under our experimental conditions, which matches well with earlier reports [ 24 , 37 ].

…”

Section: Discussionsupporting

confidence: 92%

Electrochemical Sensor for Bilirubin Detection Using Screen Printed Electrodes Functionalized with Carbon Nanotubes and Graphene

Thangamuthu

Gabriel

Santschi

et al. 2018

Sensors

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Practice oriented point-of-care diagnostics require easy-to-handle, miniaturized, and low-cost analytical tools. In a novel approach, screen printed carbon electrodes (SPEs), which were functionalized with nanomaterials, are employed for selective measurements of bilirubin, which is an important biomarker for jaundice. Multi-walled carbon nanotubes (MWCNT) and graphene separately deposited on SPEs provide the core of an electrochemical sensor for bilirubin. The electrocatalytic activity towards bilirubin oxidation (bilirubin to biliverdin) was observed at +0.25 V. In addition, a further peak corresponding to the electrochemical conversion of biliverdin into purpurin appeared at +0.48 V. When compared to MWCNT, the graphene type shows a 3-fold lower detection limit (0.3 ± 0.022 nM and 0.1 ± 0.018 nM, respectively), moreover, the graphene type exhibits a larger linear range (0.1–600 µM) than MWCNT (0.5–500 µM) with a two-fold better sensitivity, i.e., 30 nA µM−1 cm−2, and 15 nA µM−1 cm−2, respectively. The viability is validated through measurements of bilirubin in blood serum samples and the selectivity is ensured by inhibiting common interfering biological substrates using an ionic nafion membrane. The presented approach enables the design and implementation of low cost and miniaturized electrochemical sensors.

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…”

Section: Discussionsupporting

confidence: 92%

Electrochemical Sensor for Bilirubin Detection Using Screen Printed Electrodes Functionalized with Carbon Nanotubes and Graphene

Thangamuthu

Gabriel

Santschi

et al. 2018

Sensors

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show abstract

“…The third process occurs at higher potentials and only with MWCNT film-based SPEs. All these oxidation processes were found to be irreversible under our experimental conditions, as some authors have already shown [16,19]. Peaks I and II are attributed to the oxidation of BR and of BV, respectively (Reactions 1 and 2).…”

Section: Cyclic Voltammetry With Bare and Nanostructured Spesmentioning

confidence: 66%

“…Therefore, the electrochemistry of BR has been investigated in detergents such as Tris Buffer [13,16] or in organic solvents such as dimethyl sulfoxide (DMSO) [17], dimethyl formaldehyde [18] and room temperature ionic liquids [19]. To simulate the physiological environment, some authors have also investigated the …”

Section: Introductionmentioning

confidence: 99%

Superior sensing performance of multi-walled carbon nanotube-based electrodes to detect unconjugated bilirubin

et al. 2013

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The direct electrochemical behaviour of bilirubin in the physio-pathological concentration range and at physiological pH was investigated by cyclic voltammetry. Nanostructured electrodes with a thin film of multi-walled carbon nanotubes exhibited a higher sensing performance than bare electrodes. The detection limit obtained with nanostructured electrodes (4.2 ± 0.1 μM) allows the detection of both normal and pathological levels of bilirubin. Due to its sparse solubility in aqueous solvents, in human fluids bilirubin is found in the form of soluble complex with albumin. Therefore, the nanostructured-sensor response was studied in presence of different concentrations of this protein. A signal weakening was observed with increasing concentrations of albumin due to the decrease of free bilirubin. Finally, bilirubin detection was tested at concentrations typical of newborn jaundice (200-500 μM) and in the presence of normal albumin levels. A detection limit of 9.4 ± 0.3 μM was identified. Since this value is below the minimum critical bilirubin concentration for newborns, our sensor, modified with a thin film of carbon nanotubes, could potentially be used for bilirubin detection in cases of newborn jaundice.

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“…During the electrolytic oxidation of BR in dimethyl sulfoxide and dimethyl formamide , the formation of various tetrapyrrolic derivatives was recorded. The reaction rate generally increases with increasing of solvent polarity .…”

Section: Introductionmentioning

confidence: 96%

Kinetics and Mechanism of Bilirubin Oxidation by Benzoyl Peroxide in Dimethyl Sulfoxide

Serebryakova

Solomonov

Rumyantsev

et al. 2014

Int J of Chemical Kinetics

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The kinetics of the redox reaction of bilirubin by the action of benzoyl peroxide in dimethyl sulfoxide was analyzed. It is shown that the first reaction product is biliverdin, which oxidizes to purpurin and further to choletelin. The kinetic and activation parameters of the oxidation reactions were obtained. A kinetic model of the process was proposed. An assumed route of the reaction is related to the exchange interaction of CH protons of methylene and methine spacers with free radicals in the rate‐limiting step with the further destruction of the “ridge‐tile” pigment conformation. The mechanism steps are confirmed by quantum‐chemical calculations and HPLC. It is found that in organic solvents the end products of bilirubin oxidation are not monopyrrolic derivatives. The data obtained will be useful in constructing antioxidant action models of the pigment.

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Voltammetric Behavior of Bilirubin Based on [bmim][PF6] As the Supporting Electrolyte in Organic Solvent and Its Analytical Application

Cited by 8 publications

References 20 publications

Electrochemical Sensor for Bilirubin Detection Using Screen Printed Electrodes Functionalized with Carbon Nanotubes and Graphene

Electrochemical Sensor for Bilirubin Detection Using Screen Printed Electrodes Functionalized with Carbon Nanotubes and Graphene

Superior sensing performance of multi-walled carbon nanotube-based electrodes to detect unconjugated bilirubin

Kinetics and Mechanism of Bilirubin Oxidation by Benzoyl Peroxide in Dimethyl Sulfoxide

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