Voltammetric behaviour of levodopa and its quantification in pharmaceuticals using a β-cyclodextrine doped poly (2,5-diaminobenzenesulfonic acid) modified electrode

Abstract

A cyclic voltammetric method based on a β-cyclodextrine doped poly(2,5-diaminobenzenesulfonic acid) modified glassy carbon electrode (GCE) was developed for the determination of levodopa. Compared with bare GCE and poly(2,5-diaminobenzenesulfonic acid)/GCE, the poly(2,5-diaminobenzenesulfonic acid)-β-cyclodextrine/GCE exhibits a remarkable shift of the oxidation potentials of levodopa in the cathodic direction and a drastic enhancement of the anodic current response. The incorporation of β-cyclodextrine into the polymer film exhibited that the electrode provides more stable and sensitive current responses for levodopa. Levodopa exhibited a single broad peak at about 0⋅6 V at bare GCE. However, at the β-cyclodextrine doped poly(2,5-diaminobenzenesulfonic acid)/GCE, a well-defined redox wave of levodopa was obtained, with the oxidation and the reduction peak potential at 0⋅193 and 0⋅164 V, respectively. The separation of peak potentials was 29 mV. The linear current response was obtained in the range of 1⋅0 × 10 -6 ~ 2⋅0 × 10 -4 M with a detection limit of 4⋅18 × 10 -7 M for levodopa, The poly(2,5-diaminobenzenesulfonic acid)-β-cyclodextrine/GCE was also effective to simultaneously detect levodopa and ascorbic acid. The modified electrode has been successfully applied for the determination of levodopa in pharmaceuticals. The poly(2,5-diaminobenzenesulfonic acid)-β-cyclodextrine/GCE showed excellent stability and reproducibility.

Selective determination of L-dopa in the presence of uric acid and ascorbic acid at a gold nanoparticle self-assembled carbon nanotube-modified pyrolytic graphite electrode

“…Clearly, the anodic peak current increases linearly with L-dopa concentration ranging from 0.1 to 150 M, the linear regress progression is I p L-dopa (A) = (0.388 ± 0.596) + (1.073 ± 0.011) (M), with a correlation coefficient of 0.998. The detection limit is 50 nM (S/N = 3), which is better than that of the latest reports [30,41,42]. The relative standard deviation of 10 determinations for 10 M is 0.93%, showing the good reproducibility of the proposed electrode.…”

Iron Oxide Nanoparticle and Multiwalled Carbon Nanotube Modified Glassy Carbon Electrodes. Application to Levodopa Detection

“…The Fe 2 O 3 NP/MWCNT‐modified electrodes were electrochemically characterized by cyclic voltammetry (CV), using the oxidation of hexacyanoferrate (II), as model electroactive species. They were then applied as electrochemical sensors, illustrated by the electrocatalytic oxidation of levodopa (LD), a precursor for dopamine production in the human body, used as an important drug in the treatment of Parkinson's disease .…”

Ternary mutual diffusion coefficients of aqueous {l-dopa (1)+β-CD (2)} solutions at T=298.15K

“…Electrochemical sensors have been developed for quantification of this drug in recent years, which use a b-cyclodextrin/poly (N-acetylaniline) [5]. For example, Aslanoglu et al [6] proposed a b-cyclodextrin doped poly(2,5-diami nobenzenesulfonic acid) modified glassy carbon electrode for detection of the L-dopa/cyclodextrin species.…”