Voltammetric Determination of Captopril on a Glassy Carbon Electrode Modified with Copper Metal‐organic Framework

Abstract

We report in this work, a new method for the determination of captopril by differential pulse voltammetry using a glassy carbon electrode modified with a copper metal‐organic framework (H‐Kust‐1 or Cu3(BTC)2 or Cu‐BTC), immobilized on the surface by a copolymer of acrylamide and sodium acrylate. This compound is detected by the formation of a copper(II)‐captopril complex that is observed in an oxidation potential at ca. +0.28 V vs. Ag/AgCl. A linear dynamic range is obtained for a captopril concentration of 0.5 μM to 7.0 μM and the voltammetric response is highly reproducible within 3.52 % error. The sensitivity of 9.71±0.37 nA μM−1 and the limit of detection of 0.20±0.01 μM make this methodology highly applicable for practical applications. The determination of captopril in a commercial pharmaceutical sample showed a recovery of 93.3 %.

Copper Based Organic Framework Modified Electrosensor for Selective and Sensitive Detection of Ciprofloxacin

“…But copper MOF is reported as an electroactive MOF as the copper atoms in Cu BTC are present in Cu (II) oxidation state with partially occupied d-orbitals, which results in the metallic states at the Fermi level [55]. The electrochemical activity of Cu BTC MOF is studied by various researchers where it has been explored as a sensing platform for different analytes [34][35][36]46].…”

“…Various applications of this MOF have been explored by different researchers [32][33][34]. But only few researchers have explored its electrochemical behaviour and application for electrochemical determination of various analytes [34][35][36]. In this study, we explored the redox behaviour of Cu BTC and its potential use as an electrode modifying material for the electrochemical determination of ciprofloxacin antibiotic in aqueous media.…”

Voltammetric Detection of Captopril in a Commercial Drug Using a Gold‐Copper Metal‐organic Framework Nanocomposite Modified Electrode

“…In recent studies, electrodes modified with metal‐organic frameworks (MOFs) have been employed as electrochemical sensors [14, 15]. MOFs are organic‐inorganic hybrid coordination polymers that posses high stability, porosity, crystallinity and organic functionality [18, 19].…”

“…In the wake of this pioneering study, a wide variety of materials have been used to modify electrode surfaces including gold nanoparticles [2], graphene oxide [3], metal complexes [4] and multi-walled carbon nanotubes [5]. Typically, such modifications have aimed to increase the sensitivity, selectivity or stability of electrodes [6] for the detection of target analytes such as rutin [7,8], sertraline [9], uric acid [10], hydrazine [11], cysteine [12], glutathione [13,14] and captopril [15][16][17].…”

Rutin as an Electrochemical Mediator in the Determination of Captopril using a Graphite Paste Electrode

“…Conventional techniques, including chromatography , fluorimetry , chemiluminescence and spectroscopy , are available for monitoring the levels of captopril, but they all require a specialized clinical laboratory and analysis can be both time consuming and expensive. In contrast, electrochemical methods typically offer a number of advantages that include simplicity, high sensitivity, rapid detection time and low cost . However, the electrochemical detection of thiols at glassy carbon electrodes is challenging since direct oxidation of the analyte occurs only at high positive potential .…”