2017
DOI: 10.1007/s11696-017-0135-6
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Voltammetric determination of mesalazine in pharmaceutical preparations and biological samples using boron-doped diamond electrode

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Cited by 38 publications
(7 citation statements)
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“…Mesalazine (5‐ASA), is well‐established compound used in the management of inflammatory bowel disease, was quantified by Štěpánková and coauthors using SWV methodology . The authors used BR buffer solution (pH 7.0) on BDD electrode (doping level of 1000 ppm).…”
Section: Electroanalysis Of Pharmaceuticalsmentioning
confidence: 99%
“…Mesalazine (5‐ASA), is well‐established compound used in the management of inflammatory bowel disease, was quantified by Štěpánková and coauthors using SWV methodology . The authors used BR buffer solution (pH 7.0) on BDD electrode (doping level of 1000 ppm).…”
Section: Electroanalysis Of Pharmaceuticalsmentioning
confidence: 99%
“…7 Once 5-ASA is taken, it is metabolized to its derivative N-acetylated-5-ASA by Nacetyltransferase in the intestinal tract and liver where the N-acetylated-5-ASA is an antioxidant that attracts free radicals which is hypothetically injured by the creation of metabolism. 8 5-ASA is required to be analytically measured related to its therapeutic use in the treatment of inflammatory bowel disease where levels in the blood or plasma allow the concentration of the medication in a patient's body to be known, ensuring that it falls within the therapeutic range. Monitoring 5-ASA levels can help optimize the dosing regimen, ensuring that the drug is effective and not being underdosed or overdosed.…”
Section: Introductionmentioning
confidence: 99%
“…MEZ as an anti-inflammatory drug is used for treating the common disease of inflammatory bowel and Crohn's disease (3,4) .Commonly reported 5-ASA adverse effects to consist of headache, diarrhea, bloating, nausea, hypersensitivity with rare side effects include interstitial nephritis, pancreatitis, dermatitis, myocarditis and alopecia whereas nephrotoxi city is seen with any of 5-ASA compounds (5,6) . Figure (1) shown the chemical structure of mesalazine (7) . Figure 1.…”
Section: Introductionmentioning
confidence: 99%
“…Figure 1. Mesalazine chemical structure (7) MES is an antioxidant and derivate of salicylic acid that traps free radicals, which are potentially harmful species by-products of metabolism. It is a major metabolite present in blood with a half-life of up to 10 h (8) With its significance in the pharmaceuticals industry, quality control in pharmacopeia through various analytical methods has been used to analyze MSA in actual samples, such as liquid chromatography (LC) (9) With its significance in the pharmaceuticals industry, quality control in pharmacopeia through various analytical methods has been used to analyze MES in actual samples, such as chromatographic (10,11,12,13) .…”
Section: Introductionmentioning
confidence: 99%