Voltammetric determination of pyridoxine (vitamin B6) in drugs using a glassy carbon electrode modified with chromium(III) hexacyanoferrate(II)

Abstract

, respectivamente. O método proposto para a determinação voltamétrica da vitamina B 6 apresentou uma boa exatidão e os resultados experimentais demonstraram que o eletrodo de carbono vítreo modificado com hexacianoferrato(II) de Cr III apresenta um grande potencial para análise de piridoxina em amostras reais. Além disso, apresenta vantagens como uma resposta rápida, um baixo limite de detecção, baixo custo e simplicidade no desenvolvimento e aplicação. A CrIII hexacyanoferrate(II) (CrHCF)-modified glassy carbon electrode was used to determine pyridoxine (vitamin B 6 ) in three drugs by cyclic voltammetry. The influence of several parameters on the voltammetric electrode response was analyzed. The linear range found was of 1.33 × 10 -6 mol L -1 to 1.32 × 10 -5 mol L -1 of vitamin, with r = 0.9990 and relative standard deviation of 4.2%. The limits of detection and quantification were 3.46 × 10 -7 mol L -1 and 1.05 × 10 -6 mol L -1 , respectively. The voltammetric proposed method for determination of vitamin B 6 presented good accuracy and the experimental results demonstrated that the CrHCF-modified glassy carbon electrode has a large potential for the analysis of pyridoxine in real samples. Furthermore, it has the advantages of a fast response, a low detection limit, low cost, and simple development and application.

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“…Vitamin B 6 comprises seven compounds: pyridoxal, pyridoxine (Py), pyridoxamine and their respective 5′-phosphates (Bowling, 2011). Among them, the commonly given and popular food supplement as vitamin B 6 is pyridoxine (Cottica et al, 2009). However, pyridoxal-5′-phosphate (PLP) is the metabolically active form of vitamin B 6 , involved in many aspects of macronutrient metabolism, neurotransmitter synthesis, histamine synthesis, hemoglobin synthesis-function, and gene expression (Toney, 2005).…”

Voltammetric determination of vitamin B6 (Pyridoxine) using multi wall carbon nanotube modified carbon-ceramic electrode

“…5B) and then decreases at higher pHs. On the other hand, the anodic peak current of pyridoxine at MWCNT/CCE shows a hill shaped variation with pH in the range of 2.5-11.0 [14,15,28,30]. A current decrease was observed when pH of the solution is lower than 5.0 (pH<pK a1 ), due to the formation of the pyridoxine acidic form (pK a1 =5.0 and pK a2 =8.96) [31,32].…”

Simultaneous Estimation of Isoniazid and Pyridoxine Hydrochloride in Tablet Dosage Form by Spectrophotometry Ultraviolet With Area Under Curve Method

“…Some analytical methods have been developed for the quantitative analysis of INH or PDX in pure individual drugs, in their combination, in the pharmaceutical dosage forms, and in the biological fluids. These methods are Fourier transform infrared [4], voltammetric assay [5,6], spectrophotometry ultraviolet (UV) [7][8][9][10][11][12][13][14][15], polarography [12] and chemiluminescence [13], reverse phase (RP)-liquid chromatography (LC) [14], RP-high-performance LC [15], and high-performance thin LC [16].…”