Voltammetric determination of tinidazole in pharmaceutical tablets using carbon paste electrode

Abstract

ABSTRACT. Cyclic voltammetry was used to study the electrochemical behavior of tinidazole at carbon paste electrode. Tinidazole showed an irreversible reduction peak at about -440 mV. The differential pulse voltammetric peak current of tinidazole showed linear dependence on concentration in the range 5.0-200 μM with LOD and LOQ of 5.1  10 -7 and 1.7  10 -6 μM, respectively. Relative to most of the reported works on the determination of tinidazole, the developed method using carbon paste electrode which is an environmentally friendly, cheap, and simple working electrode exhibited linear dependence of peak current on concentration in the lower concentration region with relatively low LOD. Excellent recovery results with low % RSD for spiked standard tinidazole in tablet samples showed the potential applicability of the developed method for the determination of tinidazole in real samples.

Electrochemical Behaviour of Tinidazole at 1,4-Benzoquinone Modified Carbon Paste Electrode and Its Direct Determination in Pharmaceutical Tablets and Urine by Differential Pulse Voltammetry

“…The results revealed that voltammetric responses were strongly pH dependent in the acidic region in contrast to the neutral and alkaline mediums which was in agreement with most of the electrochemical methods reported [7, 9, 10]. A peak potential independent of pH in the neutral and alkaline medium could be attributed to the unavailability of protons that promote the reduction of TDZ at pHs larger than its pka value.…”

“…Using (2) ( αn ) was estimated from (2) to about 2.096 for a scan rate of 100 mV. Substituting the Γ term of (3) into (1) a new relation for n is obtained:$\begin{array}{c}T1n=\frac{\mathrm{2.718}{I}_{\mathrm{P}\mathrm{C}}RT}{\left(\alpha n\right)FQ\nu }.\end{array}$Using (4) the number of electrons transferred in the electrode reaction ( n ) was calculated to be 4.413 which indicated that by approximation four electrons were involved in the reduction of TDZ on the 1,4-BQMCPE, a comparable result with earlier reported works [10]. The value of α is thus calculated to be 0.475 for TDZ still confirming the irreversibility of the reduction of TDZ on 1,4-BQMCPE.…”

“…Many methods have been developed and applied in the detection of TDZ like electrochemical techniques [6–10], titrimetric [11], spectrophotometry [11–17], and HPLC [12, 16, 18–22]. …”

Voltammetric study of secnidazole and its determination in pharmaceutical tablet using 1, 4-benzoquinone modified carbon paste electrode

“…Table 3 indicated that most of the selected interferents did not significantly affect the peak current response for the SCZ which is comparable with a result reported somewhere (Elqudabyet al, 2013;Youssef et al, 2015). But metronidazole and tinidazole showed positive interference on the peak current for SCZ and this is because both metronidazole (Nikodimos and Amare, 2016) and tinidazole (Taye and Amare, 2016;Nikodimos and Hagos, 2017) contain the same reductive groups that can be reduced near the potentials of SCZ.…”

A Novel Electrochemical Strategy for the Highly Sensitive Investigation of Tinidazole Using Newly Designed Halloysite Nano Clay and TiO2 Based Sensor

“…3 Nonetheless, TDZ is proven to cause many side effects also which include stomach discomfort, itching, bitter sense of taste and diarrhea, with the potential for experiencing negative symptoms like headaches, muscular fatigue and dizziness. 4 Hence, determination of TDZ in micro amounts is crucial.…”