Voltammetric electronic tongue combined with chemometric techniques for direct identification of creatinine level in human urine

Saidi, Tarik; Moufid, Mohammed; Zaim, Omar; Bari, Nezha El; Bouchikhi, Benachir

doi:10.1016/j.measurement.2017.10.044

Cited by 34 publications

(10 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…From a fundamental perspective, our work offers a facile methodology to obtain direct molecular insight on enantiodifferentiation on various chiral surfaces. The combination of signature vibrational fingerprint and chemometrics, which has previously been employed for SERS detection in biofluids, , further creates a high potential for our system to be capable of supporting real sample measurements for various applications such as disease diagnosis and drug quality control, by identifying spectral fingerprints of target enantiomers while eliminating interfering signals present in complex biological matrices.…”

Section: Discussionmentioning

confidence: 99%

Enantiospecific Molecular Fingerprinting Using Potential-Modulated Surface-Enhanced Raman Scattering to Achieve Label-Free Chiral Differentiation

et al. 2021

View full text Add to dashboard Cite

Chiral differentiation is critical in diverse fields ranging from pharmaceutics to chiral synthesis. While surface-enhanced Raman scattering (SERS) offers molecule-specific vibrational information with high detection sensitivity, current strategies rely on indirect detection using additional selectors and cannot exploit SERS’ key advantages for univocal and generic chiral differentiation. Here, we achieve direct, label-free SERS sensing of biologically important enantiomers by synergizing asymmetric nanoporous gold (NPG) nanoparticles with electrochemical-SERS to generate enantiospecific molecular fingerprints. Experimental and in silico studies reveal that chiral recognition is two pronged. First, the numerous surface atomic defects in NPG provide the necessary localized asymmetric environment to induce enantiospecific molecular adsorptions and interaction affinities. Concurrently, the applied potential drives and orients the enantiomers close to the NPG surface for maximal analyte–surface interactions. Notably, our strategy is versatile and can be readily extended to detect various enantiomers. Furthermore, we can achieve multiplex quantification of enantiomeric ratios with excellent predictive performance. Our combinatorial approach thus offers an important paradigm shift from current approaches to achieve label-free chiral SERS sensing of various enantiomers.

show abstract

Section: Discussionmentioning

confidence: 99%

Enantiospecific Molecular Fingerprinting Using Potential-Modulated Surface-Enhanced Raman Scattering to Achieve Label-Free Chiral Differentiation

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Many techniques for urinary creatinine content evaluation require sample dilution with other reagents to overcome the obstacles caused by the matrix effect. A voltammetric MSS to determine the creatinine content in 59 urine non-diluted samples was proposed in [66]. The MSS comprised seven working electrodes (glassy carbon, Au, Pt, Ag, Ni, Pd, and Cu), Ag/AgCl as a reference, and Pt as the auxiliary electrode.…”

Section: Medical Analysismentioning

confidence: 99%

Electronic Tongues for Inedible Media

Kirsanov

Corrêa

Gaál

et al. 2019

Sensors

View full text Add to dashboard Cite

“Electronic tongues”, “taste sensors”, and similar devices (further named as “multisensor systems”, or MSS) have been studied and applied mostly for the analysis of edible analytes. This is not surprising, since the MSS development was sometimes inspired by the mainstream idea that they could substitute human gustatory tests. However, the basic principle behind multisensor systems—a combination of an array of cross-sensitive chemical sensors for liquid analysis and a machine learning engine for multivariate data processing—does not imply any limitations on the application of such systems for the analysis of inedible media. This review deals with the numerous MSS applications for the analysis of inedible analytes, among other things, for agricultural and medical purposes.

show abstract

“…Briefly, an e-tongue is a multisensory system employed in the analysis of complex liquid media that transforms raw data into specific recognition patterns that are further visualized through computational and statistical analysis [9][10][11]. There is a myriad of applications in the literature including not only 2 of 11 edible foodstuff [12] and beverages [13][14][15][16] but also in non-edible analytes, such as environmental pollutants [17][18][19], pesticides [20,21], elements of medical concern [22][23][24], and soil [25,26].…”

Section: Introductionmentioning

confidence: 99%

3D-Printed Graphene Electrodes Applied in an Impedimetric Electronic Tongue for Soil Analysis

et al. 2019

View full text Add to dashboard Cite

The increasing world population leads to the growing demand for food production without expanding cultivation areas. In this sense, precision agriculture optimizes the production and input usage by employing sensors to locally monitor plant nutrient within agricultural fields. Here, we have used an electronic tongue sensing device based on impedance spectroscopy to recognize distinct soil samples (sandy and clayey) enriched with macronutrients. The e-tongue setup consisted of an array of four sensing units formed by layer-by-layer (LbL) films deposited onto 3D-printed graphene-based interdigitated electrodes (IDEs). The IDEs were fabricated in 20 min using the fused deposition modeling process and commercial polylactic acid-based graphene filaments. The e-tongue comprised one bare and three IDEs functionalized with poly(diallyldimethylammonium chloride) solution/copper phthalocyanine-3,4 ,4 ,4 -tetrasulfonic acid tetrasodium salt (PDDA/CuTsPc), PDDA/montmorillonite clay (MMt-K), and PDDA/poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) LbL films. Control samples of sandy and clayey soils were enriched with different concentrations of nitrogen (N), phosphorus (P), and potassium (K) macronutrients. Sixteen soil samples were simply diluted in water and measured using electrical impedance spectroscopy, with data analyzed by principal component analysis. All soil samples were easily distinguished without pre-treatment, indicating the suitability of 3D-printed electrodes in e-tongue analysis to distinguish the chemical fertility of soil samples. Our results encourage further investigations into the development of new tools to support precision agriculture.

show abstract

Voltammetric electronic tongue combined with chemometric techniques for direct identification of creatinine level in human urine

Cited by 34 publications

References 32 publications

Enantiospecific Molecular Fingerprinting Using Potential-Modulated Surface-Enhanced Raman Scattering to Achieve Label-Free Chiral Differentiation

Enantiospecific Molecular Fingerprinting Using Potential-Modulated Surface-Enhanced Raman Scattering to Achieve Label-Free Chiral Differentiation

Electronic Tongues for Inedible Media

3D-Printed Graphene Electrodes Applied in an Impedimetric Electronic Tongue for Soil Analysis

Contact Info

Product

Resources

About