Voltammetric investigation of DNA damage induced by nitrofurazone and short-lived nitro-radicals with the use of an electrochemical DNA biosensor

Ni, Yongnian; Wang, Pingping; Kokot, Serge

doi:10.1016/j.bios.2012.05.034

Cited by 42 publications

(10 citation statements)

References 34 publications

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“…NFZ is an effective fungicide, amoebicide and skin sensitizer, which resists various allergies and infections related to animals and humans [30]. It can also be used for the treatment of enteritis, and boils caused by coli or salmonella bacteria.…”

Section: Introductionmentioning

confidence: 99%

“…Consequently, rapid and sensitive analytical methods for NFZ are required, particularly in the fields of bioassay and chemistry. In this context many methods have been developed: spectrophotometry [34], chromatography [35], high performance liquid chromatography (HPLC) with fluorescence detection (HPLC-FLD) [36], voltammetry [30], FI-CL method [37] and fluorescence [38].…”

Section: Introductionmentioning

confidence: 99%

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The use of tungsten disulfide dots as highly selective, fluorescent probes for analysis of nitrofurazone

Guo

Wang

et al. 2015

Talanta

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The use of tungsten disulfide dots as highly selective, fluorescent probes for analysis of nitrofurazone

Guo

Wang

et al. 2015

Talanta

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“…ROS cause oxidative stress and various diseases by disrupting the structure of DNA, proteins, and lipids. 14,15 Different types of DNA damage induced by ROS, 16 UV exposure, 17 and mutagenic species 18 can be detected by biosensor design. The use of electrochemical DNA biosensors and voltammetric techniques to study the mechanisms of biomolecular interaction of various molecules with DNA is advantageous and continues to attract the attention of scientists over the years.…”

Section: Supplementary Materials For This Article Is Available Onlinementioning

confidence: 99%

Phosphodiesterase-3 Enzyme Inhibitor Drug Milrinone Interaction with DNA and HSA: Electrochemical, Spectroscopic and Molecular Docking

Ünal¹,

Erkmen²,

Selcuk³

et al. 2022

J. Electrochem. Soc.

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In this study, the interaction between the phosphodiesterase-3 enzyme inhibitor drug milrinone and biomolecules was investigated by electrochemical, fluorescence spectroscopy, and molecular docking studies for the first time. The interaction between milrinone and biomolecules was investigated according to the decrease in deoxyguanosine oxidation signals of milrinone and calf thymus double-stranded deoxyribonucleic acid (ct-dsDNA) by cyclic voltammetry and differential pulse voltammetry. In fluorescence spectroscopy studies, a competitive study was conducted on ct-dsDNA by adding a well-known fluorescent methylene blue and ct-dsDNA solution. The fluorescent results showed that milrinone had a higher affinity for ct-dsDNA binding compared to methylene blue. Interaction studies show that milrinone binds to ct-dsDNA via a groove-binding mode, and the binding constant values were calculated as 4.27 × 106 M-1 and 6.03 × 104 M-1 at 25 °C, based on cyclic voltammetry and spectroscopic results, respectively. As a result of the interaction of human serum albumin and milrinone, the binding coefficient was calculated as 4.11 × 106 M-1 by cyclic voltammetry. In addition, experimental results were confirmed by obtaining information about the possible spatial structure of the aggregate formed through theoretical calculations based on energy minimization for milrinone- ct-dsDNA and milrinone-human serum albumin mixtures with molecular insertion.

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“…Antibiotics are artificial or semi-artificial products that can affect the growth and metabolic activity of microorganisms, which are secondary metabolites of fungi, bacteria, and microorganisms and their analogues. 23 A moderate amount of antibiotics can help biologic artifacts to treat diseases, and simultaneously, excessive antibiotic accumulation can have a negative impact on the environment and organisms' health. Nitrofurazone (NFZ) is an organic compound used for disinfection and antisepsis.…”

Section: Introductionmentioning

confidence: 99%

Chiral Carbon Quantum Dots Encapsulated in ZIF-8 Nanoparticles for Turn-On Recognition of Chiral Folic Acid and Nitrofurazone and Applications as Fluorescent Inks

Liu

Geng

Wang

et al. 2022

ACS Appl. Nano Mater.

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Metal−organic frameworks (MOFs) are a kind of nanoporous coordination materials, which have the advantages of high crystallinity and tunable functionalization. Carbon dots (CDs) are zerodimensional luminescent carbon nanomaterials, which combine the advantages of small organic molecules such as fluorophores and conventional semiconductors such as inorganic quantum dots. Chiral quantum dots are appealing for detection of chiral substances due to their unique chirality. In this work, chiral CDs can be loaded into zeolitic imidazolate framework-8 (ZIF-8) via an in situ encapsulation method, forming the chiral composite hybrid material CCQDs/ZIF-8 (1). The framework structure and luminescent property of 1 can be maintained after being soaked in water and ethanol for 24 h as confirmed by PXRD characterization. A luminescent experiment demonstrated that 1 can be utilized as a highly sensitive and selective "turn-on" fluorescent probe of Dfolic acid (K BH 9.82 × 10 4 M −1 and detection limit 0.31 μM) and L-folic acid (K BH 2.99 × 10 4 M −1 and detection limit 4.36 μM). 1 also shows good cycling detection performance for D-folic acid (94.96%) and L-folic acid (93.69%). Enantioselective identification between D-folic acid and L-folic acid (K D /K L = 3.28) can be carried out. Furthermore, simultaneously, 1 can be used as an efficient turn-on fluorescence probe to detect the antibiotic nitrofurazone (NFZ; K BH 3.29 × 10 4 M −1 and detection limit 3.06 μM). Further, 1 can be utilized to detect folic acid and NFZ in real samples. The results demonstrated that 1 can be used as a highly efficient turnon detection platform for folic acid and NFZ. Further, 1 with these targeted objects can be successfully applied as a fluorescent ink; a mixed-matrix membrane based on 1 has been prepared. The detection mechanism of composite material 1 for recognition of folic acid and NFZ is also investigated and discussed.

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Voltammetric investigation of DNA damage induced by nitrofurazone and short-lived nitro-radicals with the use of an electrochemical DNA biosensor

Cited by 42 publications

References 34 publications

The use of tungsten disulfide dots as highly selective, fluorescent probes for analysis of nitrofurazone

The use of tungsten disulfide dots as highly selective, fluorescent probes for analysis of nitrofurazone

Phosphodiesterase-3 Enzyme Inhibitor Drug Milrinone Interaction with DNA and HSA: Electrochemical, Spectroscopic and Molecular Docking

Chiral Carbon Quantum Dots Encapsulated in ZIF-8 Nanoparticles for Turn-On Recognition of Chiral Folic Acid and Nitrofurazone and Applications as Fluorescent Inks

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