Voltammetric studies of the interaction of transition-metal complexes with DNA

Lu, Xiaoquan; Zhu, Kaimei; Zhang, Min; Liu, Hongde; Kang, Jingwan

doi:10.1016/s0165-022x(02)00074-x

Cited by 64 publications

(18 citation statements)

References 10 publications

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“…The comparative redox behavior of complexes 1 and 3, and their interaction with CT-DNA were studied by CV. The cyclic voltammogram of complex 1 exhibited one quasi-reversible redox couple corresponding to the Cu II /Cu I [47] with E p values of 0.290 and 0.390 V at scan rate 0.2 Vs À 1 , and I pa /I pc ratio is 0.44 ( Fig. 8, a).…”

mentioning

confidence: 99%

Chiral and Achiral Macrocyclic Copper(II) Complexes: Synthesis, Characterization, and Comparative Binding Studies with Calf-Thymus DNA

Chauhan

Arjmand

2006

C&B

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The new chiral macrocyclic complexes [1,2-bis(1H-benzimidazol-2-yl)-1- (1,8-dihydro-1,3,5,8,10,12-hexaazacyclotetradecane)-2-hydroxyethanolate] copper(II) and -nickel(II) perchlorate, 3 and 4, respectively, were synthesized by the reaction of 1,2-bis(1H-benzimidazol-2-yl)ethane-1,2-diol (L) and (1,8-dihydro-1,3,5,8,10,12-hexaazacyclotetradecane)copper(II) and -nickel(II) diperchlorate complexes, 1 and 2, respectively. All complexes were characterized by various spectroscopic techniques. Molarconductance measurements showed that all of the complexes are ionic in nature. In complexes 3 and 4, the metal center is encapsulated by the ligand L in a pentacoordinated environment. The optical-rotation values ([a] D ) of 3 and 4 at 258 indicate that the complexes are chiral. Absorption-and fluorescencespectral studies, cyclic voltammetry, and viscosity measurements have been carried out to assess the comparative binding of complexes 1 and 3 with calf thymus (CT)-DNA. Analysis of the results suggests that the new chiral complex 3 binds to CT-DNA through a partial intercalation mode that is different from the binding mode of parent achiral complex 1. The complexes 1 and 3 bind to CT-DNA with binding constants K b of 2.7 Â 10 4 and 6.6 Â 10 4 m À 1 , respectively. Circular-dichroism (CD) studies have been further employed to ascertain the binding mode of complex 3, which is consistent with the other spectral studies.

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confidence: 99%

Chiral and Achiral Macrocyclic Copper(II) Complexes: Synthesis, Characterization, and Comparative Binding Studies with Calf-Thymus DNA

Chauhan

Arjmand

2006

C&B

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“…Cyclic voltammetry (CV) is employed to study the interaction of metal complexes with DNA, owing to the resemblance between electrochemical and biological reactions. Based on the shift of the formal potentials in the cyclic voltammograms, the relative binding affinities and binding modes of the metal complexes with DNA can be deduced [66]. The redox behavior of the bis-macrocyclic complexes 1 and 3 in absence and presence of CT DNA has been studied by means of CV in H 2 O/DMSO 95 : 5 over a sweep range of 1.6 to À 0.8 V at a scan rate of 0.2 Vs…”

Section: Results Andmentioning

confidence: 99%

Synthesis and Biophysical Studies of Bis‐Macrocyclic Cobalt/Copper(II) Complexes Having a Pyridine Spacer with CT DNA and 5′‐GMP

Arjmand

Aziz

2009

Chemistry & Biodiversity

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New bis-macrocyclic complexes of Co(III), 1, Ni(II), 2, and Cu(II), 3, containing pyridyl bridges between 13-membered macrocyclic subunits, have been synthesized via an in situ one-pot template condensation reaction (IOPTCR). The proposed structures of these new dinuclear complexes are consistent with the data obtained from elemental analysis, molar conductance, IR, EPR, UV/VIS, (1)H- and 13C-NMR, and ESI-MS. The complexes 2 and 3 possess square-planar geometry with four secondary N-atoms coordinated to the metal ion, while complex 1 reveals octahedral geometry in solution due to coordinated H(2)O molecules. DNA-Binding properties of the complexes 1 and 3 were investigated by absorption and emission titrations, cyclic voltammetry, and viscosity measurements. Complexes 1 and 3 are strong DNA binders with binding constants, K(b), of 1.64 x 10(5) and 2.05 x 10(5) M(-1), respectively. Hyperchromism, decrease in emission intensity of DNA-bound ethidium bromide (EB), and changes observed in the viscosity and cyclic voltammograms in the presence of added metal complexes reveals that the complexes bind to DNA predominantly by electrostatic attraction, substantiated by absorption titration with 5'-GMP.

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“…The ratio of binding constant K + /K 2+ is equal to 1, suggesting that both Cu (II) and Cu (I) forms interact with DNA to the same extent [36]. The cyclic voltammogram of complex 5 in absence of CT-DNA shows ΔE p = 0.105 V (Fig.…”

Section: Cyclic Voltammetry Studiesmentioning

confidence: 94%

New homodi-and heterotrinuclear metal complexes of Schiff base compartmental ligand: interaction studies of copper complexes with calf thymus DNA

Mathur

Tabassum

2006

Open Chemistry

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The new homodinuclear complexes 1-4 of the type [LMhave been synthesized and characterized by elemental analysis and various spectroscopic techniques. The homodinuclear complexes possess two different environments (N 2 and N 2 O 2 donor sets) for holding the metal ions. The metal ion in N 2 set exhibits square planar geometry with two chloride ions in the inner sphere but rhombic structure is found in tetradentate N 2 O 2 Schiff base cavity while in heterotrinuclear complexes Sn IV atom is in the octahedral environment. The interaction of complexes 1 and 5 with calf thymus DNA was carried out by absorption spectroscopy and cyclic voltammetry. The intrinsic binding constants (K b ) of complex 1 and 5 were determined as 3.2 × 10 3 M −1 and 9.6 × 10 3 M −1 , respectively suggesting that complex 5 binds more strongly to CT-DNA than complex 1. Fluorescence studies along with viscosity measurements have also been checked to authenticate the binding of metal complexes with DNA.

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Voltammetric studies of the interaction of transition-metal complexes with DNA

Cited by 64 publications

References 10 publications

Chiral and Achiral Macrocyclic Copper(II) Complexes: Synthesis, Characterization, and Comparative Binding Studies with Calf-Thymus DNA

Chiral and Achiral Macrocyclic Copper(II) Complexes: Synthesis, Characterization, and Comparative Binding Studies with Calf-Thymus DNA

Synthesis and Biophysical Studies of Bis‐Macrocyclic Cobalt/Copper(II) Complexes Having a Pyridine Spacer with CT DNA and 5′‐GMP

New homodi-and heterotrinuclear metal complexes of Schiff base compartmental ligand: interaction studies of copper complexes with calf thymus DNA

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