Voltammetry of local anesthetics: theoretical and practical aspects

Pysarevska, Solomiya; Plotycya, Serhiy; Dubenska, Liliya

doi:10.1080/10408347.2020.1729691

Cited by 8 publications

(5 citation statements)

References 58 publications

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“…In voltammetric analysis, the modification of the working electrode surface may be motivated by various reasons, e.g., to improve the selectivity, sensitivity and detection limit of the method [ 33 , 34 ]. By coating a working electrode surface with an organic film, e.g., a plasticized PVC membrane, analyte molecules spontaneously partition into the membrane.…”

Section: Resultsmentioning

confidence: 99%

Plasticized PVC Membrane Modified Electrodes: Voltammetry of Highly Hydrophobic Compounds

et al. 2020

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In the last 50 years, plasticized polyvinyl chloride (PVC) membranes have gained unique importance in chemical sensor development. Originally, these membranes separated two solutions in conventional ion-selective electrodes. Later, the same membranes were applied over a variety of supporting electrodes and used in both potentiometric and voltammetric measurements of ions and electrically charged molecules. The focus of this paper is to demonstrate the utility of the plasticized PVC membrane modified working electrode for the voltammetric measurement of highly lipophilic molecules. The plasticized PVC membrane prevents electrode fouling, extends the detection limit of the voltammetric methods to sub-micromolar concentrations, and minimizes interference by electrochemically active hydrophilic analytes.

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Section: Resultsmentioning

confidence: 99%

Plasticized PVC Membrane Modified Electrodes: Voltammetry of Highly Hydrophobic Compounds

et al. 2020

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“…Commonly used sample pretreatment steps for HPLC are extraction of the analytes of interest into a liquid solvent or a solid phase. As usually, this step takes approximately 75 % of all time needed for analysis [13]. Despite of high selectivity and low limit of quantitation, chromatography suffers from such restrictions like expensive equipment and materials, toxic organic solvents, long duration of analysis.…”

Section: Introductionmentioning

confidence: 99%

“…Electrochemical methods are an alternative to traditional methods, to which there are both HPLC and titrimetry and spectrophotometry [13]. It should be emphasized that in recent years voltammetry (VA) methods are extremely used and developed in pharmaceutical analysis [14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Study of Different Carbonaceous Materials as Modifiers of Screen‐printed Carbon Electrodes for the Triazid as Potential Antiviral Drug

et al. 2022

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In this work a comparative study of Screen-Printed Carbon Electrodes (SPCE) -bare and modified by drop casting with carbonaceous nanomaterials (CNMs) as Multi Walled Carbon Nanotubes (MWCNT), Carbon Black and Functionalized Carbon Black for voltammetric determination of 5-methyl-6-nitro-7-oxo-4,7-dihydro-1,2,4-triazolo[1,5-a]pyrimidinide l-arginine monohydrate (Triazid) as a potential drug with a broad spectrum of antiviral activity is reported. Bare SPCE and CNMs modified SPCE (SPCE/CNMs) have been characterized morphologically by SEM and electrochemically by cyclic voltammetry/electrochemical impedance spectroscopy with [Fe(CN) 6 ] 4À /3À as redox probe. Significant improvement of electrochemical performances is achieved with SPCE/CNMs compared with the bare SPCE. Among SPCE/CNMs studied SPCE modified with MWCNT (SPCE/CNT) is characterized by the best combination of electrochemical properties and electroanalytical performance towards TD. The linear dynamic range is 25-200 mg L À 1 (R 2 = 0.9975) with the limit of detection -2.8 mg L À 1 Triazid using SPCE/CNT and Square-Wave Voltammetry technique. The developed sensor was successfully used for Triazid determination in the Pharmaceutical Substance "TRIAZID". The results achieved with SPCE/CNMs after chemical binding of dissolved oxygen in 0.04 M Britton-Robinson buffer + 0.04 M Na 2 SO 3 (pH 7.2 � 0.2) are very useful for further development of cost-effective and time-consuming pharmaceutical routine assay.

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“…Benzocaine (ethyl 4-aminobenzoate), a local anesthetic, has a prevailing clinical application for local and temporal pain relief of wounds, ulcer surfaces, burns, skin scratches, and hemorrhoids [ 1 ]. In 2011, two Food and Drug Administration (FDA) Drug Safety Communications were issued warning that the use of benzocaine, the main ingredients in over-the-counter (OTC) gels and liquids applied to the gums or mouth to reduce pain, can cause methemoglobinemia—a rare but serious condition in which the amount of oxygen carried through the blood stream is greatly reduced related to topical use during medical procedures [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Determination of Benzocaine in Pharmaceutical Formulations by Indirect SERRS Assay Combined with Azo Coupling

et al. 2022

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Coupled with an azo coupling reaction, a simple, rapid, sensitive, and effective surface-enhanced resonance Raman scattering (SERRS) detection method for benzocaine was developed. In our study, benzocaine which is used clinically as a local anesthetic was derived with p-aminothiophenol into a corresponding azo product within 5 min, resulting in a strong SERRS response with the simple addition of Ag NPs excited with a 532 nm laser. The linear correlation between SERRS intensity of dominant bands and logarithm of benzocaine concentration was investigated for quantitative determination. The method reached a limit of detection (LOD) down to 0.139 and 0.0788 μg/mL calculated with two peak intensity ratios (I1568/I2260 and I1331/I2260), which is comparable to most studies reported previously, and meanwhile had superiority in simplicity and rapidness. The quantitative measurements for pharmaceutical preparations with benzocaine were conducted without complex extraction and enrichment processes. It was indicated that the SERRS assay combined with azo derivatization reaction has implications for practical applications in more complicated systems involving biological samples, in which appropriate and simplified pretreatments were conducted to remove interfering components.

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Voltammetry of local anesthetics: theoretical and practical aspects

Cited by 8 publications

References 58 publications

Plasticized PVC Membrane Modified Electrodes: Voltammetry of Highly Hydrophobic Compounds

Plasticized PVC Membrane Modified Electrodes: Voltammetry of Highly Hydrophobic Compounds

Study of Different Carbonaceous Materials as Modifiers of Screen‐printed Carbon Electrodes for the Triazid as Potential Antiviral Drug

Determination of Benzocaine in Pharmaceutical Formulations by Indirect SERRS Assay Combined with Azo Coupling

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