Volume-Doubling Time of Pulmonary Nodules with Ground Glass Opacity at Multidetector CT

Oda, Shigeto; Awai, Kazuo; Murao, Kohei; Ozawa, Akio; Utsunomiya, Daisuke; Yanaga, Yumi; Kawanaka, Koichi; Yamashita, Yasuyuki

doi:10.1016/j.acra.2010.08.022

Cited by 65 publications

(67 citation statements)

References 34 publications

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“…This finding is in line with previous literature data (7,25), although the observed volume-DT was longer than that reported by Oda et al (21) (mean, 486.4±368.6 days; range, 89-1583 days) using in-house semi-automated software. Such differences might be related to the different sample size and different study design, as we included only GGOs greater than or equal to 8 mm, and each lesion was examined during follow-up with the same scanner and same acquisition/reconstruction protocol.…”

Section: Discussionsupporting

confidence: 68%

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Pulmonary adenocarcinomas presenting as ground-glass opacities on multidetector CT: three-dimensional computer-assisted analysis of growth pattern and doubling time

Borghesi

Farina²,

Michelini³

et al. 2016

Diagn Interv Radiol

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We aimed to evaluate the growth pattern and doubling time (DT) of pulmonary adenocarcinomas exhibiting ground-glass opacities (GGOs) on multidetector computed tomography (CT). METHODS The growth pattern and DT of 22 pulmonary adenocarcinomas exhibiting GGOs were retrospectively analyzed using three-dimensional semiautomatic software. Analysis of each lesion was based on calculations of volume and mass changes and their respective DTs throughout CT follow- up. Three-dimensional segmentation was performed by a single radiologist on each CT scan. The same observer and another radiologist independently repeated the segmentation at the baseline and the last CT scan to determine the variability of the measurements. The relationships among DTs, histopathology, and initial CT features of the lesions were also analyzed. RESULTS Pulmonary adenocarcinomas presenting as GGOs exhibited different growth patterns: some lesions grew rapidly and some grew slowly, whereas others alternated between periods of growth, stability, or shrinkage. A significant increase in volume and mass that exceeded the coefficient of repeatability of interobserver variability was observed in 72.7% and 84.2% of GGOs, respectively. The volume-DTs and mass-DTs were heterogeneous throughout the follow-up CT scan (range, -4293 to 21928 and -3113 to 17020 days, respectively), and their intra- and interobserver variabilities were moderately high. The volume-DTs and mass-DTs were not correlated with the initial CT features of GGOs; however, they were significantly shorter in invasive adenocarcinomas (P = 0.002 and P = 0.001, respectively). CONCLUSION Pulmonary adenocarcinomas exhibiting GGOs show heterogeneous growth patterns with a trend toward a progressive increase in size. DTs may be useful for predicting tumor aggressiveness

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Section: Discussionsupporting

confidence: 68%

“…Furthermore, Oda et al (21) reported that volume-DT may be helpful in differentiating the histologic entities of GGOs.…”

mentioning

confidence: 99%

Pulmonary adenocarcinomas presenting as ground-glass opacities on multidetector CT: three-dimensional computer-assisted analysis of growth pattern and doubling time

Borghesi

Farina²,

Michelini³

et al. 2016

Diagn Interv Radiol

View full text Add to dashboard Cite

show abstract

“…Interestingly, the VDTs of part-solid GGNs that were proven to be adenocarcinomas were shorter than those of pure-GGNs that were also histologically proven to be adenocarcinomas (457±260 vs. 813±375 days) (39). With the finding that the internal attenuation of SSNs had a significant correlation with the VDT, Oda et al (39) suggested that SSNs with high VDT for ≤3 cm Noguchi type A and B lesions, which included five tumors with >50% of GGO proportion and one solid nodule. The VDT was calculated using the mean of the longest and shortest diameters of the tumor measured on the initial and final chest radiography.…”

Section: Natural Clinical Course Of Subsolid Nodulesmentioning

confidence: 99%

Section: Natural Clinical Course Of Subsolid Nodulesmentioning

confidence: 99%

“…Some retrospective studies have revealed that part-solid GGNs grow faster than pure GGNs and that adenocarcinomas manifesting as SSNs showed shorter volume doubling (39). Interestingly, the VDTs of part-solid GGNs that were proven to be adenocarcinomas were shorter than those of pure-GGNs that were also histologically proven to be adenocarcinomas (457±260 vs. 813±375 days) (39). With the finding that the internal attenuation of SSNs had a significant correlation with the VDT, Oda et al (39) suggested that SSNs with high VDT for ≤3 cm Noguchi type A and B lesions, which included five tumors with >50% of GGO proportion and one solid nodule.…”

Section: Natural Clinical Course Of Subsolid Nodulesmentioning

confidence: 99%

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