Volume expansion suppresses the tooth-pulp evoked jaw-opening reflex related activity of trigeminal neurons in rats

Takeda, Masatoshi; Tanimoto, Tsuyoshi; Nishikawa, Toshimi; Ikeda, Mizuho; Yoshida, Shinki; Ito, Masahiro; Matsumoto, Shigeji

doi:10.1016/s0361-9230(02)00763-3

Cited by 21 publications

(10 citation statements)

References 27 publications

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“…This finding is consistent with human studies that have reported nVNS provides a therapeutic benefit that is similar to that of sumatriptan for the acute treatment of episodic migraine (11). Our finding that nVNS inhibits the average number of nocifensive responses to mechanical stimulation mediated by a pungent odor is also consistent with results from an earlier study (23) and with results from other animal studies that mimic aspects of migraine pathology (24,29,30) and other types of orofacial pain (31,32). While previous studies have utilized nitric oxide donors to directly cause trigeminal nociception (24,33,34), in our model, a subthreshold concentration of sodium nitroprusside promoted activation of trigeminal nocifensive response in sensitized animals.…”

Section: Discussionsupporting

confidence: 91%

Inhibition of Trigeminal Nociception by Non-invasive Vagus Nerve Stimulation: Investigating the Role of GABAergic and Serotonergic Pathways in a Model of Episodic Migraine

2020

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Migraine is a prevalent neurological disease that is characterized by unpredictable episodic attacks of intense head pain. The underlying pathology involves sensitization and activation of the trigeminal system. Although non-invasive vagus nerve stimulation (nVNS) is recommended for the treatment of migraine, the abortive mechanism of action is not well-understood. The goal of this study was to compare the ability of nVNS and sumatriptan to inhibit trigeminal activation in two animal models of episodic migraine and to investigate the receptor mechanism of action of nVNS. Nocifensive head withdrawal response was investigated in adult male Sprague Dawley rats using von Frey filaments. To induce trigeminal nociceptor sensitization, complete Freund's adjuvant was injected in the trapezius muscle and trigeminal neurons were activated by exposure to a pungent odor or injection of the nitric oxide donor sodium nitroprusside. Some animals received nVNS or sumatriptan as treatment. Some animals were injected intracisternally with antagonists of GABA A , 5-HT3 or 5-HT7 receptors prior to nVNS since these receptors are implicated in descending modulation. While unsensitized animals exposed to the pungent odor or nitric oxide alone did not exhibit enhanced mechanical nociception, sensitized animals with neck muscle inflammation displayed increased trigeminal nocifensive responses. The enhanced nociceptive response to both stimuli was attenuated by nVNS and sumatriptan. Administration of antagonists of GABA A , 5-HT3, and 5-HT7 receptors in the upper spinal cord suppressed the anti-nocifensive effect of nVNS. Our findings suggest that nVNS inhibits trigeminal activation to a similar degree as sumatriptan in episodic migraine models via involvement of GABAergic and serotonergic signaling to enhance central descending pain modulation.

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Section: Discussionsupporting

confidence: 91%

Inhibition of Trigeminal Nociception by Non-invasive Vagus Nerve Stimulation: Investigating the Role of GABAergic and Serotonergic Pathways in a Model of Episodic Migraine

2020

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“…The jaw opening reflex (JOR) elicited by the suprathreshold stimulation of the tooth pulp has been considered a valid measurement of nociceptive response (Boissonade and Matthews 1993;Chiang et al 1989Chiang et al , 1991Mahan and Anderson 1970;Schmidt et al 2002a;Takeda et al 2002;Tambeli et al 2002;Zhang et al 1998Zhang et al , 1999. We have previously shown in anesthetized rats that electrical or chemical stimulation of the striatum, within a specific region, results in the inhibition of the JOR (Belforte et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Striatal Inhibition of Nociceptive Responses Evoked in Trigeminal Sensory Neurons by Tooth Pulp Stimulation

Belforte

Pazo²

2005

Journal of Neurophysiology

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The noxious evoked response in trigeminal sensory neurons was studied to address the role of striatum in the control of nociceptive inputs. In urethane-anesthetized rats, the jaw opening reflex (JOR) was produced by suprathreshold stimulation of the tooth pulp and measured as electromyographic response in the digastric muscle, with simultaneous recording of noxious responses in single unit neurons of the spinal trigeminal nucleus pars caudalis (Sp5c). The microinjection of glutamate (80 mol/0.5 l) into striatal JOR inhibitory sites significantly decreased the A␦ and C fiber-mediatedevoked response (53 Ϯ 4.2 and 43.6 Ϯ 6.4% of control value, P Ͻ 0.0001) in 92% (31/34) of nociceptive Sp5c neurons. The microinjection of the solvent was ineffective, as was microinjection of glutamate in sites out of the JOR inhibitory ones. In another series of experiments, simultaneous single unit recordings were performed in the motor trigeminal nucleus (Mo5) and the Sp5c nucleus. Microinjection of glutamate decreased the noxious-evoked response in Sp5c and Mo5 neurons in parallel with the JOR, without modifying spontaneous neuronal activity of trigeminal motoneurons (n ϭ 8 pairs). These results indicate that the striatum could be involved in the modulation of nociceptive inputs and confirm the role of the basal ganglia in the processing of nociceptive information.

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“…Evoked inhibitory GABAergic pre- and post-synaptic potentials in the periaqueductal gray (PAG) are partially inhibited by opiates acting via μ-opioid receptors [42]. Neuronal activity in the PAG is increased after blockade of μ-opioid receptors as a result of GABAergic disinhibition, resulting in the subsequent activation of serotonergic (5-hydroxytrypytamine (5-HT)) neurons in the nucleus raphe magnus, known as the PAG–nucleus raphe magnus–trigeminal pathway [43,44]. Resveratrol has been shown to facilitate 5-HT 3 receptor-mediated ion currents [18], and nociceptive stimulation-evoked SpVc/C1 neuron activity is suppressed by conditioning peripheral nerve stimulation via 5-HT 3 receptor-mediated GABAergic inhibition [45,46].…”

Section: Potential Role For Resveratrol In Alleviating Nociceptivementioning

confidence: 99%

Modulatory Mechanism of Nociceptive Neuronal Activity by Dietary Constituent Resveratrol

Takeda

Takehana

Sekiguchi

et al. 2016

IJMS

Self Cite

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Changes to somatic sensory pathways caused by peripheral tissue, inflammation or injury can result in behavioral hypersensitivity and pathological pain, such as hyperalgesia. Resveratrol, a plant polyphenol found in red wine and various food products, is known to have several beneficial biological actions. Recent reports indicate that resveratrol can modulate neuronal excitability, including nociceptive sensory transmission. As such, it is possible that this dietary constituent could be a complementary alternative medicine (CAM) candidate, specifically a therapeutic agent. The focus of this review is on the mechanisms underlying the modulatory effects of resveratrol on nociceptive neuronal activity associated with pain relief. In addition, we discuss the contribution of resveratrol to the relief of nociceptive and/or pathological pain and its potential role as a functional food and a CAM.

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Volume expansion suppresses the tooth-pulp evoked jaw-opening reflex related activity of trigeminal neurons in rats

Cited by 21 publications

References 27 publications

Inhibition of Trigeminal Nociception by Non-invasive Vagus Nerve Stimulation: Investigating the Role of GABAergic and Serotonergic Pathways in a Model of Episodic Migraine

Inhibition of Trigeminal Nociception by Non-invasive Vagus Nerve Stimulation: Investigating the Role of GABAergic and Serotonergic Pathways in a Model of Episodic Migraine

Striatal Inhibition of Nociceptive Responses Evoked in Trigeminal Sensory Neurons by Tooth Pulp Stimulation

Modulatory Mechanism of Nociceptive Neuronal Activity by Dietary Constituent Resveratrol

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