Volume of trapped gas in lungs of healthy humans

Christensson, Per; Arborelius, M; Kautto, R.

doi:10.1152/jappl.1981.51.1.172

Cited by 33 publications

(12 citation statements)

References 4 publications

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“…VC (VC%). RV (RV%) and TLC (TLC%) were calculated front the normal values of the laborato ry [31][32][33], For the purpose of this study FEV,%and VC% were used as indicators of obstructive airway disease and TLC% as indicator of emphysema.…”

Section: Methodsmentioning

confidence: 99%

Alcohol Consumption Modifies the Total Lung Capacity in Smokers

Ström

Janzon²,

Hanson³

et al. 1996

Respiration

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Smoking-related airflow obstruction can develop with or without emphysema. Moderate alcohol consumption has been suggested to diminish the risk of centrilobular emphysema caused by smoking. Our aim was to study the influence of total energy and nutrient (protein, fat, carbohydrate and alcohol) intake on smoking-related emphysema. Lung function and nutrient intake including alcohol consumption were recorded at the age of 68 years in 478 men as part of the population study ‘Men Born in 1914’ in Malmö, Sweden. In nonsmokers (n = 88) and ex-smokers (n = 223), there were no significant relationships between energy and nutrient intake and lung function. In smokers (n = 167), men in the highest and lowest quintile of total lung capacity (TLC) differed in alcohol intake (p = 0.004) but not in intake of total energy or other nutrients. In smokers with a forced expiratory volume in 1 s/vital capacity ratio of below 70% (n = 81), alcohol intake was positively correlated with TLC (r = 0.31; p = 0.006) after adjustment for smoking and body mass index. We conclude that in men with smoking-related airway obstruction, emphysema defined as large TLC was associated with high alcohol consumption but not with the intake of total energy or other nutrients.

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Section: Methodsmentioning

confidence: 99%

Alcohol Consumption Modifies the Total Lung Capacity in Smokers

Ström

Janzon²,

Hanson³

et al. 1996

Respiration

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“…However, these measurements of lung function without pulmonary methacholine provocation may be insensitive for the detection of early stages of obstructive lung dis ease. The volume of trapped gas (VTG) is a sensitive mea sure of the function of the small airways [10]. Particularly, it has been shown to be sensitive in revealing airway hyperreactivity as shown by methacholine provocation in workers exposed to isocyanates and without FEV, changes [11],…”

Section: Allergological Examinationsmentioning

confidence: 99%

“…Volume of trapped gas (VTG) was determined by rebreathing of oxygen with five maxima of breaths at the end of the N2 washout. The equipment and technique is described by Christensson et al [10] and further developed by Hjortsberg et al [11]. For pulmonary provocation, a solution of methacholine was inhaled from a Pari nebuliser for 2 min at the concentrations 0.001,0.01,0.1 and 1 %.…”

Section: Lung Functionmentioning

confidence: 99%

Sensitization to Laboratory Animals and Small-Airway Hyperreactivity

Willers¹,

Hjortsberg²,

Ja³

et al. 1992

Indoor Built Environ

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Fifty-six laboratory-animal workers were investigated regarding allergy and lung function. Thirty percent had at least one positive skin prick test against laboratory animals. RAST® test was positive in 25%. Thirty-two percent had laboratory-animal allergy (LAA; rhinoconjunctivitis and/or asthma). Association with an increased risk for LAA was found for atopy, as indicated by a family history of allergy, positive skin prick test against nonlaboratory environmental allergens, positive Phadiatop®, and increased levels of serum IgE. The entire group of laboratory workers did not significantly differ from a reference group in airway reactivity. However, subgrouping of the workers showed that sensitized cases had significantly increased levels of volume of trapped gas (VTG), a measure of the small-airway function, after pulmonary provocation with methacholine at a concentration of 0.1 %, as compared to both a reference group and nonsensitized workers. Thus, animal allergen sensitization was found to be associated with small-airway hyperreactivity. Also, a positive Phadiatop was associated with increased levels of VTG.

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“…The reproducibility of VTG over 1 year was larger than the short-time reproduci bility (8 ml) [Christensson et al, 1981a] but still rather good. Not any of the applied tests distinguished between PiMZ and PiM subjects with the exception of VTG after salbutamol (table II), where non smoking PiMZ subjects had significantly larger VTG than nonsmoking PiM sub jects.…”

Section: Discussionmentioning

confidence: 78%

“…Recently, we have developed a method of measuring the volume of nonventilated or very slowly ventilated regions in the lungs: the volume of trapped gas (VTG) [Billow et al, 1978;Christensson et al, 1981a]. VTG is increased in subclinical bronchial asthma [Billow et al, 1978] and cystic fibrosis [Svenonius et al, 1980a], VTG decreases in patients with asthma after inhalation of bronchodilators [Billow et al, 1978;Christensson et al, 1981b] but not in patients with cystic fibrosis [Svenoniuset al, 1980a].…”

Section: Introductionmentioning

confidence: 99%

Changes of Volume of Trapped Gas after Bronchodilation in Subjects with Suspected Subclinical Emphysema

Christensson¹,

Arborelius²,

Kautto-Wiberg³

1986

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We studied the volume of trapped gas (VTG), using a nitrogen washout method, before and after bronchodilation in four groups with theoretically increasing risk of developing pulmonary emphysema: (1) nonsmoking healthy controls (PiMn), (2) nonsmoking subjects with an intermediate alpha₁-antitrypsin deficiency (PiMZn), (3) smoking subjects with normal concentration of alpha₁-antitrypsin, and (4) smoking PiMZ subjects. VTG was the only lung function variable that showed a significant difference between PiMZn and PiMn subjects but only after bronchodilation. Some conventional lung function tests also distinguished smokers from nonsmokers of both genotypes but VTG was the most sensitive test. VTG decreased after salbutamol inhalation in the control group but showed a consecutively larger increase with more risk factors of developing emphysema. An increase in VTG after bronchodilation may be a sign of alveolar abnormality preceding development of clinical lung emphysema.

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Volume of trapped gas in lungs of healthy humans

Cited by 33 publications

References 4 publications

Alcohol Consumption Modifies the Total Lung Capacity in Smokers

Alcohol Consumption Modifies the Total Lung Capacity in Smokers

Sensitization to Laboratory Animals and Small-Airway Hyperreactivity

Changes of Volume of Trapped Gas after Bronchodilation in Subjects with Suspected Subclinical Emphysema

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