Volume‐pressure properties of the upper airway in normal subjects and patients with obstructive sleep apnoea

Wu, Denan; Hida, Wataru; Kikuchi, Yoshihiro; Okabe, Shinichi; Kurosawa, Hájíme; Ogawa, Hiroyasu; Shirato, Kunio

doi:10.1046/j.1440-1843.1999.00149.x

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…Table 4 indicates that trachea displays a high degree of expansibility under physiological pressure conditions, which range from À1.5 to 1 kPa. 33 Both Nonlinear Model and Linear Model are capable of showing that the airway displays an excellent distensibility when the pressure is around zero and tends to be in expansible quickly when the pressure further increases or decreases.…”

Section: Discussionmentioning

confidence: 99%

Study on Tracheal Collapsibility, Compliance, and Stress by Considering Nonlinear Mechanical Property of Cartilage

Zhang

Ochoa

et al. 2009

Ann Biomed Eng

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Tracheal cartilage has been widely regarded as a linear elastic material either in experimental studies or in analytic and numerical models. However, it has been recently demonstrated that, like other fiber-oriented biological tissues, tracheal cartilage is a nonlinear material, which displays higher strength in compression than in extension. Considering the nonlinearity requires a more complex theoretical frame work and costs more to simulate. This study aims to quantify the deviation due to the simplified treatment of the tracheal cartilage as a linear material. It also evaluates the improved accuracy gained by considering the nonlinearity. Pig tracheal rings were used to exam the mechanical properties of cartilage and muscular membrane. By taking into account the asymmetric shape of tracheal cartilage, the collapse behavior of complete rings was simulated, and the compliance of airway and stress in the muscular membrane were discussed. The results obtained were compared with those assuming linear mechanical properties. The following results were found: (1) Models based on both types of material properties give a small difference in representing collapse behavior; (2) regarding compliance, the relative difference is big, ranging from 10 to 40% under negative pressure conditions; and (3) the difference in determining stress in the muscular membrane is small too: <5%. In conclusion, treating tracheal cartilage as a linear material will not cause big deviations in representing the collapse behavior, and mechanical stress in the muscular part, but it will induce a big deviation in predicting the compliance, particularly when the transmural pressure is lower than -0.5 kPa. The results obtained in this study may be useful in both understanding the collapse behavior of trachea and in evaluating the error induced by the simplification of treating the tracheal cartilage as a linear elastic material.

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Section: Discussionmentioning

confidence: 99%

Study on Tracheal Collapsibility, Compliance, and Stress by Considering Nonlinear Mechanical Property of Cartilage

Zhang

Ochoa

et al. 2009

Ann Biomed Eng

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New Strategies of Screening and Treatment for Sleep Apnea Syndrome.

Hida

1998

Tohoku J. Exp. Med.

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The prevalence of sleep apnea syndrome (SAS) is approximately 7.5% in Japanese adults aged 18-68 years old. SAS is characterized by repeated episodes of apnea, especially obstructive apnea, during sleep. Severe SAS has life-threatening complications such as pulmonary hypertension, arrhythmias, right heart failure or brain damage, which could be caused by hypoxemia and/or hypercapnia. Upper airway relaxation is responsible for the obstruction during apnea, and an increase in the activities of the upper airway muscles dilates and stiffens the upper airway wall. Maintaining the activities of the upper airway muscles may contribute to keeping the airway patent. Submental electrical stimulation of the upper airway muscles would be a novel treatment method for obstructive apnea.

show abstract

Volume‐pressure properties of the upper airway in normal subjects and patients with obstructive sleep apnoea

Cited by 2 publications

References 29 publications

Study on Tracheal Collapsibility, Compliance, and Stress by Considering Nonlinear Mechanical Property of Cartilage

Study on Tracheal Collapsibility, Compliance, and Stress by Considering Nonlinear Mechanical Property of Cartilage

New Strategies of Screening and Treatment for Sleep Apnea Syndrome.

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