Volumetric Blood Flow Measurement in the Ophthalmic Artery Using Colour Doppler

Katamay, Robert; Fleischlin, C; Gugleta, Konstantin; Orgül, Selim

doi:10.1055/s-0028-1109304

Cited by 5 publications

(5 citation statements)

References 10 publications

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“…2002; Zeitz et al. 2006b; Katamay et al. 2009), but limited data on reproducibility may currently limit the use of this technique in clinical studies (Zeitz et al.…”

Section: Specific Parametersmentioning

confidence: 99%

“…Estimation of the vessel diameter from these reconstructions allows calculation of volumetric flow based on volumetric measurements. Attempts have been made to measure absolute blood flow in the OA (Michelson & Schuierer 1991;Orge et al 2002;Zeitz et al 2006b;Katamay et al 2009), but limited data on reproducibility may currently limit the use of this technique in clinical studies (Zeitz et al 2006a,b). It must also be kept in mind that the velocity of red cells in the centre of the vessel is not the same as near the vessel wall, and a single value does not represent the range of velocities and cannot be simply multiplied by the vessel's crosssectional area to obtain volume of flow in absolute terms.…”

Section: Measured Parametersmentioning

confidence: 99%

“…Currently, the methodologies of CDI are limited in their ability to provide volumetric rates (Siesky et al 2010). As mentioned previously, attempts have been made to perform volumetric flow measurements (Michelson & Schuierer 1991;Orge et al 2002;Zeitz et al 2006b;Katamay et al 2009).…”

Section: Main Limitations and Advantagesmentioning

confidence: 99%

See 2 more Smart Citations

Use of colour Doppler imaging in ocular blood flow research

Stalmans

Vandewalle

Anderson

et al. 2011

Acta Ophthalmologica

132

114

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. The main objective of this report is to encourage consistent quality of testing and reporting within and between centres that use colour Doppler imaging (CDI) for assessment of retrobulbar blood flow. The intention of this review is to standardize methods in CDI assessment that are used widely, but not to exclude other approaches or additional tests that individual laboratories may choose or continue to use.

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“…2002; Zeitz et al. 2006b; Katamay et al. 2009), but limited data on reproducibility may currently limit the use of this technique in clinical studies (Zeitz et al.…”

Section: Specific Parametersmentioning

confidence: 99%

Section: Measured Parametersmentioning

confidence: 99%

See 1 more Smart Citation

Use of colour Doppler imaging in ocular blood flow research

Stalmans

Vandewalle

Anderson

et al. 2011

Acta Ophthalmologica

132

114

View full text Add to dashboard Cite

show abstract

“…Many ideas have been developed to identify systemic diseases from the eye by gaining information about the vascular state 28,29 . Few studies have been conducted to link the heart and the eye via ECG to assess the pulsatile vessel calibre on fundus photographs or with ultrasound to assess the larger carotid or ophthalmic arteries in synchronicity with the heart [30][31][32][33] . To the best of our knowledge, we present the first link of an ECG with OCT to assess retinal blood flow profiles.…”

Section: Discussionmentioning

confidence: 99%

Heart-retina time analysis using electrocardiogram-coupled time-resolved dynamic optical coherence tomography

Valmaggia,

Wolleb,

Bieder

et al. 2024

Preprint

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The eye and the heart are two closely interlinked organs, and many diseases affecting the cardiovascular system manifest in the eye. To contribute to the understanding of blood flow propagation towards the retina, we developed a method to acquire electrocardiogram (ECG) coupled time-resolved dynamic optical coherence tomography (OCT) images. This method allows for continuous synchronised monitoring of the cardiac cycle and retinal blood flow dynamics. The dynamic OCT measurements were used to calculate time-resolved blood flow profiles using fringe washout analysis. The relative fringe washout was computed to generate the flow velocity profiles within arterioles at the optic nerve head rim. We found that the blood column between the heart and the retina propagates within one cardiac cycle, denoting the arrival time as the heart-retina time (HRT). In a group of healthy subjects, the HRT was 144 ± 19 ms (mean ± SD). The HRT could provide a novel potential biomarker for cardiovascular health in direct relation to retinal perfusion.

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“…However, CDI does not provide quantitative data on vessel diameter. Some approaches have been attempted to estimate vascular diameter for the measurement of volumetric blood flow in the OA, but these methods have shown limited reproducibility [40][41][42]. Central retinal artery (CRA) and central retinal vein (CRV) can be identified in the middle of the optic nerve.…”

Section: Technical Aspectsmentioning

confidence: 99%

Measurement of Retrobulbar Blood Flow and Vascular Reactivity—Relevance for Ocular and Cardiovascular Diseases

Böhm,

Grauhan,

Pfeiffer

et al. 2023

Diagnostics

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Abnormal retrobulbar hemodynamics have been linked to the development of various ocular diseases, including glaucoma, age-related macular degeneration, and diabetic retinopathy. Additionally, altered retrobulbar blood flow has been observed in patients with severe cardiovascular diseases, including carotid artery occlusion, stroke, heart failure, and acute coronary syndrome. Due to the complex and intricate anatomy of retrobulbar blood vessels and their location behind the eyeball, measurement of retrobulbar blood flow and vascular reactivity, as well as the interpretation of the findings, are challenging. Various methods, such as color Doppler imaging, computed tomography angiography or magnetic resonance imaging, have been employed to assess retrobulbar blood flow velocities in vivo. Color Doppler imaging represents a fast and non-invasive method to measure retrobulbar blood flow velocities in vivo. While no information about vessel diameter can be gained performing this method, computed tomography angiography and magnetic resonance imaging provide information about vessel diameter and detailed information on the anatomical course. Additionally, ex vivo studies, such as myography, utilizing genetically modified animal models may provide high optical resolution for functional vascular investigations in these small vessels. To our best knowledge, this is the first review, presenting a detailed overview of methods aiming to evaluate retrobulbar blood flow and vascular reactivity in both humans and laboratory animals. Furthermore, we will summarize the disturbances observed in retrobulbar blood flow in retinal, optic nerve, and cardiovascular diseases.

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Volumetric Blood Flow Measurement in the Ophthalmic Artery Using Colour Doppler

Abstract: Our method allows volumetric blood flow measurements in the ophthalmic artery in absolute units, reproducible to a limited extent.

Cited by 5 publications

References 10 publications

Use of colour Doppler imaging in ocular blood flow research

Use of colour Doppler imaging in ocular blood flow research

Heart-retina time analysis using electrocardiogram-coupled time-resolved dynamic optical coherence tomography

Measurement of Retrobulbar Blood Flow and Vascular Reactivity—Relevance for Ocular and Cardiovascular Diseases

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