Volumetric evaluation of the lung expansion following resection: a stereological study☆

Objective. The aim of this study was to determine the posterior cranial fossa volume, cerebellar volume, and herniated tonsillar volume in patients with chiari type I malformation and control subjects using stereological methods. Material and Methods. These volumes were estimated retrospectively using the Cavalieri principle as a point-counting technique. We used magnetic resonance images taken from 25 control subjects and 30 patients with chiari type I malformation. Results. The posterior cranial fossa volume in patients with chiari type I malformation was significantly smaller than the volume in the control subjects (P < 0.05). In the chiari type I malformation group, the cerebellar volume was smaller than the control group, but this difference was not statistically significant (P > 0.05). In the chiari type I malformation group, the ratio of cerebellar volume to posterior cranial fossa volume was higher than in the control group. We also found a positive correlation between the posterior cranial fossa volume and cerebellar volume for each of the groups (r = 0.865, P < 0.001). The mean (±SD) herniated tonsillar volume and length were 0.89 ± 0.50 cm3 and 9.63 ± 3.37 mm in the chiari type I malformation group, respectively. Conclusion. This study has shown that posterior cranial fossa and cerebellum volumes can be measured by stereological methods, and the ratio of these measurements can contribute to the evaluation of chiari type I malformation cases.

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“…

V_{V} (X, Y) = \frac{Volume of X phase in Y reference space}{Volume of Y reference space} .

Volume fraction ranges from 0 to 1 and is often expressed as a percentage [15–17]. …”

Section: Methodsmentioning

confidence: 99%

Analysis of the Volumes of the Posterior Cranial Fossa, Cerebellum, and Herniated Tonsils Using the Stereological Methods in Patients with Chiari Type I Malformation

Vurdem

Acer

Ertekın

et al. 2012

The Scientific World Journal

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“…First, we could not measure the exact volume of each lobe. Postoperative volume changes could be assessed by Cavalieri's principle [28]. However, the method is not simple, and the analysis of a large population might be impossible.…”

Section: Commentmentioning

confidence: 99%

Changes in Pulmonary Function in Lung Cancer Patients After Video-Assisted Thoracic Surgery

Kim¹,

Lee²,

Park³

et al. 2015

The Annals of Thoracic Surgery

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“…Objects have a volume (three dimensions), a surface (two dimensions), a length (one dimension) and a number (zero dimension). Each of these properties can be estimated by stereological methods (Gundersen, 1986;Basoglu et al 2007).…”

Section: Introductionmentioning

confidence: 99%

The effects of high‐fat diet on the renal structure and morphometric parametric of kidneys in rats

et al. 2008

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To characterize the kidney in a high-fat-induced obesity model, we examined the renal structure of adult SpragueDawley rats fed a control diet or a high-fat diet for 3 months. Ten adult female Sprague-Dawley rats were fed a diet consisting highly of fat (30%) for a period of 3 months. Ten control rats were maintained with standard rat chow. All animals were weighed every 10 days for 3 months. At the end of the experiment, the naso-anal length of the anaesthetized rats was measured to calculate body mass index, and subsequently whole kidneys of intracardially formalin-perfused animals were removed. Quantitative features of the kidney were analysed with the Cavalieri and physical dissector methods applied to serial paraffin sections. Kidney samples were also examined histologically. The body mass indices of the control and treatment groups were 4.528 ± 0.242 and 5.876 ± 0.318 kg m -2 , respectively. The difference between the body mass indices of the two groups was statistically significant ( P < 0.01, Mann-Whitney U -test), suggesting that the animals fed with a high-fat diet may be overweight. Stereological examination of the kidneys revealed differences in kidney weight, total kidney volume, volume of cortex, medulla, glomeruli, proximal and distal tubules, and numerical density of glomeruli and glomerular height in the treatment group compared with the control group. Light microscopic investigation showed a dilatation in blood vessels and Bowman's space, mononuclear cell infiltration, degeneration in nephrons, including glomerulosclerosis and tubular defects, and an increase in the connective tissue in the kidneys in the treatment group. We concluded that a fatty diet is responsible for the rats' obesity and may lead to renal deformities as a result of histopathological changes such as dilatation, tubular defects, inflammation and connective tissue enlargement of the kidney.

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Volumetric evaluation of the lung expansion following resection: a stereological study☆

Cited by 11 publications

References 15 publications

Analysis of the Volumes of the Posterior Cranial Fossa, Cerebellum, and Herniated Tonsils Using the Stereological Methods in Patients with Chiari Type I Malformation

Analysis of the Volumes of the Posterior Cranial Fossa, Cerebellum, and Herniated Tonsils Using the Stereological Methods in Patients with Chiari Type I Malformation

Changes in Pulmonary Function in Lung Cancer Patients After Video-Assisted Thoracic Surgery

The effects of high‐fat diet on the renal structure and morphometric parametric of kidneys in rats

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