Volumetric evidence of a left laterality effect in epileptic psychosis

Marchetti, R.; Azevedo, Dionı́sio; Bottino, Cássio Machado de Campos; Kurcgant, Daniela; Marques, Andrea de Fátima Horvath; Marie, Suely Kazue Nagahashi; Arruda, Paulo Corrêa Vaz de

doi:10.1016/s1525-5050(03)00056-8

Cited by 26 publications

(19 citation statements)

References 27 publications

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“…However, given the lack of an epilepsy comparison group, the specificity of these findings to POE, as opposed to epilepsy in general, is unclear 27. Finally, no differences in hippocampal volume were identified between patients with TLE with and without psychosis in a 2006 study by Flügel et al 28…”

Section: Resultsmentioning

confidence: 97%

“…Other limitations of some of the manual tracing studies of the hippocampus in POE include the lack of an epilepsy comparison group27 and small sample sizes (all studies <40 subjects (table 3)) 46 49 50. Despite these shortcomings, the lack of consistent evidence of changes in mesial temporal regions in POE suggests that its aetiology involves extramesial temporal regions, although this does not exclude the possibility of hippocampal involvement.…”

Section: Discussionmentioning

confidence: 99%

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Systematic review of structural and functional brain alterations in psychosis of epilepsy

Allebone

Kanaan

Wilson

2017

J Neurol Neurosurg Psychiatry

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Epilepsy ABSTRACTThis systematic review critically assesses structural and functional neuroimaging studies of psychosis of epilepsy (POe). we integrate findings from 18 studies of adults with POe to examine the prevailing view that there is a specific relationship between temporal lobe epilepsy (TLe) and POe, and that mesial temporal lobe pathology is a biomarker for POe. Our results show: (1) conflicting evidence of volumetric change in the hippocampus and amygdala; (2) distributed structural pathology beyond the mesial temporal lobe; and (3) changes in frontotemporal functional network activation. These results provide strong evidence for a revised conceptualisation of POe as disorder of brain networks, and highlight that abnormalities in mesial temporal structures alone are unlikely to account for its neuropathogenesis. Understanding POe as a disease of brain networks has important implications for neuroimaging research and clinical practice. Specifically, we suggest that future neuroimaging studies of POe target structural and functional networks, and that practitioners are vigilant for psychotic symptoms in all epilepsies, not just TLe.

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Section: Resultsmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Systematic review of structural and functional brain alterations in psychosis of epilepsy

Allebone

Kanaan

Wilson

2017

J Neurol Neurosurg Psychiatry

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“…A relationship between TLE and psychosis is still discussed; however, some authors supposed that the apparent excess of TLE in patients with both epilepsy and psychosis is explained by the fact that TLE is the most common type of chronic epilepsy [44, 45]. Several studies postulated that psychosis affects in particular patients with left TLE [46,47,48,49,50]. In our sample, only 7 patients presented psychotic features (3% of the total sample, and 8% of the EPI-PSY group), making any conclusion in terms of lateralization difficult.…”

Section: Discussionmentioning

confidence: 99%

Psychiatric Comorbidity in Patients Evaluated for Chronic Epilepsy: A Differential Role of the Right Hemisphere?

et al. 2009

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Introduction: Psychiatric disorders are known to occur frequently in chronic epilepsy. The aim of this study is to investigate the prevalence of psychiatric comorbidity and its relationship to regional cerebral dysfunction in patients admitted to a tertiary epilepsy center for epilepsy surgery. Methods: 217 patients were investigated. A presurgical workup was performed and allowed precise localization of the epileptogenic focus in 156 patients. Sixty-one patients had multifocal or generalized discharges. After 1–3 psychiatric interviews, a psychiatric diagnosis was made (DSM-IV classification). Results: Psychiatric comorbidity was found in 85 patients (39%), more often in those with right or bilateral hemispheric dysfunction (74%, p = 0.04) with no difference between temporal or extratemporal foci location frequency. Additionally, patients with psychiatric disorders were less likely to undergo epilepsy surgery compared to ‘epilepsy-only’ patients (p = 0.003), despite similar good outcome in patients with and without psychiatric comorbidity. Conclusions: Right-sided or bilateral foci seem to represent a risk factor for psychiatric comorbidity in epilepsy, although we did not find any particular association between a psychiatric syndrome and focus localization. Recognition and treatment of psychiatric comorbidity is of major importance since its presence may interfere with patient’s decision making for epilepsy surgery treatment.

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“…A small number of structural neuroimaging studies suggest bilateral [8] or left-sided [9] loss of cerebral volume in the temporal lobes of patients with SLPE as compared to patients with TLE without psychosis. One study found more diffuse areas of abnormalities [10], though using the unbiased technique of voxel-based morphometry, another study found no differences at all [11].…”

Section: Epilepsy-related Psychosismentioning

confidence: 99%

Neuroimaging of frontal–limbic dysfunction in schizophrenia and epilepsy-related psychosis: Toward a convergent neurobiology

Butler

Weisholtz

Isenberg³

et al. 2012

Epilepsy & Behavior

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Volumetric evidence of a left laterality effect in epileptic psychosis

Cited by 26 publications

References 27 publications

Systematic review of structural and functional brain alterations in psychosis of epilepsy

Systematic review of structural and functional brain alterations in psychosis of epilepsy

Psychiatric Comorbidity in Patients Evaluated for Chronic Epilepsy: A Differential Role of the Right Hemisphere?

Neuroimaging of frontal–limbic dysfunction in schizophrenia and epilepsy-related psychosis: Toward a convergent neurobiology

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