Von Willebrand Disease in Pregnancy

A single‐centre study of management of pregnant women with von Willebrand disease

“…These results are consistent with reports in the literature showing that most women with type 1 VWD achieve VWF levels in the normal (nonpregnant) range by the third trimester. 8,9 The optimal route of delivery and the type of anaesthesia used in women with VWD remain controversial. 10 Generally, if the VWF levels are higher than 50 IU dL −1 , experts consider vaginal delivery and caesarean section to be equally safe, 7 and epidural analgesia is considered a reasonable option in women with type 1 VWD but not in women with type 2 and type 3 VWD.…”

Let's Talk Period! Preliminary results of an online bleeding awareness knowledge translation project and bleeding assessment tool promoted on social media

“…The severity of bleeding symptoms depends on the subtype of VWD, with type 1 typically being associated with more mild bleeding and types 2 and 3 with more severe bleeding . VWD does not appear to affect one ethnic group more than another . VWD is inherited in an autosomal pattern with males and females being affected equally .…”

“…2 VWD does not appear to affect one ethnic group more than another. 4 VWD is inherited in an autosomal pattern with males and females being affected equally. 2 Females are diagnosed up to three times more often compared to males as they may experience bleeding symptoms related to menstruation or childbirth.…”

Von Willebrand Disease and Pregnancy: A Review of Evidence and Expert Opinion

“…The clinical presentation of type 1 VWD is usually mild and these patients generally have a low bleeding risk. 1,3 Approximately 20% of patients with VWD have type 2 disease. Patients with type 2 VWD have abnormal VWF function.…”

“…Patients with type 2 VWD have abnormal VWF function. 1,3,5 Type 2A VWD is thought to result from a reduction in large VWF multimers. 3 Type 2B VWD is rare, representing less than 10% of all cases of VWD.…”