Vorhofflimmern – epidemiologische, ökonomische und individuelle Krankheitsbelastung

Brüggenjürgen, Bernd; Reinhold, Thomas; McBride, Doreen; Willich, S N

doi:10.1055/s-0030-1249204

Cited by 7 publications

(5 citation statements)

References 22 publications

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“…Atrial fibrillation (AF) is the most common arrhythmia in the general population. The prevalence of AF is 1–2% 1–3 and its complications have a very high socio-economic impact 4,5 due to a close relationship with ischemic stroke, embolisms, heart failure, hospitalizations and death risk along with worse quality of life, lower exercise tolerance and impaired left ventricular (LV) function 6–8 . Paroxysmal atrial fibrillation (PAF) is mainly asymptomatic 8 and diagnosis is based on long-term electrocardiographic (ECG) monitoring.…”

Section: Introductionmentioning

confidence: 99%

Improving performance of 3D speckle tracking in arterial hypertension and paroxysmal atrial fibrillation by using novel strain parameters

Esposito

Piras

Evangelista

et al. 2019

Sci Rep

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The function of left atrium (LA) is closely related to LA remodeling and one of the most important mechanisms is an increased deposition of fibrous tissue that often is the basis for LA electro-mechanical changes before the onset of atrial fibrillation (AF). This study evaluated LA shape and function, by investigating standard and novel strain parameters calculated by a new approach based on homologous times derived from 3D speckle tracking echocardiography (3DSTE) in hypertensive (HT) and paroxysmal atrial fibrillation (PAF) patients with or without left ventricular hypertrophy (LVH), compared to control (C) subjects. LA function was assessed using homologous times to compare strain variables among different individuals, acquired at different physiological time periods. Standard global longitudinal (GLS) and circumferential (GCS) strains were measured at peak of atrial diastole, while longitudinal and circumferential strains (GLSh, GCSh), strain rate (GLSr, GCSr), volume (Vh) and volume rate (Vr) were measured during the atrial telediastolic phase (fifth homologous time) and atrial pre-active phase (tenth homologous time). Using ANOVA, we found an impaired LA deformation detected by standard, interpolated strains and strain rates in both HT and PAF groups compared to C. We also performed ROC analysis to identify different performances of each parameter to discriminate groups (GLSr10 + GCSr10: C vs PAF 0.935; C vs PAF_LVH 0.924; C vs HT_LVH 0.844; C vs HT 0.756). Our study showed anatomical and functional LA remodeling in patients with PAF and HT. 3D strains and strain rates derived from the homologous times approach provide more functional information with improved performance to identify among the explored groups, in particular PAF patients.

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Section: Introductionmentioning

confidence: 99%

Improving performance of 3D speckle tracking in arterial hypertension and paroxysmal atrial fibrillation by using novel strain parameters

Esposito

Piras

Evangelista

et al. 2019

Sci Rep

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“…Für die nächsten Jahrzehnte wird aufgrund der demographischen Entwicklung mit einer Verdoppelung der Patientenzahlen gerechnet [2]. Die Mortalität ist bei Patienten mit Vorhofflimmern als Folge thromboembolischer Ereignisse erhöht [3]. Das Risiko einen ischämen Schlaganfall zu erleiden ist 5-fach erhöht [3].…”

Section: Introductionunclassified

“…Die Mortalität ist bei Patienten mit Vorhofflimmern als Folge thromboembolischer Ereignisse erhöht [3]. Das Risiko einen ischämen Schlaganfall zu erleiden ist 5-fach erhöht [3]. Aufgrund des hohen thromboembolischen Risikos umfasst die therapeutische Behandlung des Vorhofflimmerns neben der Kontrolle der Herzfrequenz auch die antithrombotische Prophylaxe [4].…”

Section: Introductionunclassified

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Kosteneffektivität von Apixaban zur Verhinderung von Schlaganfällen bei Vorhofflimmern in Deutschland

Reimer

Schöffski

2013

PharmacoEcon. Ger. Res. Artic.

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Background and Objective: Apixaban was shown to be superior to warfarin and acetylsalicylic acid in preventing stroke in patients with atrial fibrillation and at least one additional risk factor. This study compared the cost effectiveness of apixaban versus warfarin and acetylsalicylic acid in this patient population in Germany. Methods: We constructed a lifetime Markov model with 12 health states, based on the results of the Aristotle and Averroes trial, to evaluate the cost effectiveness of apixaban from the social healthcare perspective. Our base-case assumed a cohort of 65-year old patients with a CHADS 2 Score of 2.1. We used a 1-month cycle-length. The outcome was measured in quality-adjusted life-years (QALYs), costs and incremental-cost-effectiveness ratios (ICER). The robustness of the model was tested with one and two way sensitivity analyses. A probabilistic sensitivity analysis was also performed. Results: Under base case conditions, total costs per patient were € 33,427 and € 33,118 for apixaban and warfarin. Corresponding QALYs were 10.79 and 10.06 in the lifetime Markov model. The ICER was € 423 per QALY. Monte Carlo simulation demonstrated apixaban was cost-effective in 86 % and

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“…So erhöht VHF das Risiko für einen Schlaganfall um das 5-fache und ist insgesamt für 15-20 % aller Schlaganfälle verantwortlich [13]. Zudem unterscheiden sich die bisherigen Studien erheblich in der Wahl des methodischen Ansatzes [1,3,5]. Zudem unterscheiden sich die bisherigen Studien erheblich in der Wahl des methodischen Ansatzes [1,3,5].…”

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Vorhofflimmern in Deutschland – eine prospektive Krankheitskostenstudie

Spyra

Daniel

Thate-Waschke

et al. 2015

Dtsch med Wochenschr

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Vorhofflimmern – epidemiologische, ökonomische und individuelle Krankheitsbelastung

Cited by 7 publications

References 22 publications

Improving performance of 3D speckle tracking in arterial hypertension and paroxysmal atrial fibrillation by using novel strain parameters

Improving performance of 3D speckle tracking in arterial hypertension and paroxysmal atrial fibrillation by using novel strain parameters

Kosteneffektivität von Apixaban zur Verhinderung von Schlaganfällen bei Vorhofflimmern in Deutschland

Vorhofflimmern in Deutschland – eine prospektive Krankheitskostenstudie

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