Voriconazole Composited Polyvinyl Alcohol/Hydroxypropyl-β-Cyclodextrin Nanofibers for Ophthalmic Delivery

Sun, Xiaoyi; Yu, Zhenwei; Cai, Zhengyuan; Yu, Lingyan; Lv, Yuanyuan

doi:10.1371/journal.pone.0167961

Cited by 68 publications

(26 citation statements)

References 42 publications

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“…The application of nanofibres, produced by electrospinning a mixed solution of polyvinyl alcohol and HPβCD, for ophthalmic drug delivery has been investigated by Sun et al . . In rabbits, they observed a significant improvement in half‐life in rabbits compared to voriconazole ophthalmic solution.…”

Section: Cyclodextrin‐based Nanocarriers For Targeted Ocular and Nasamentioning

confidence: 94%

“…Hyperbranched CDs have been explored for enhancing insulin transport across the nasal mucosa, with a high insulin-loading content, and an in vivo reduction in blood glucose concentration, being observed [92]. The application of nanofibres, produced by electrospinning a mixed solution of polyvinyl alcohol and HPbCD, for ophthalmic drug delivery has been investigated by Sun et al [93]. In rabbits, they observed a significant improvement in half-life in rabbits compared to voriconazole ophthalmic solution.…”

Section: Cmbcdmentioning

confidence: 99%

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Cyclodextrin‐Based Formulations: A Non‐Invasive Platform for Targeted Drug Delivery

Muankaew

Loftsson

2017

Basic Clin Pharma Tox

165

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Cyclodextrins (CDs) are recognized as promising pharmaceutical excipients due to their unique ability to form watersoluble inclusion complexes with various poorly soluble compounds. The numerous investigations on CDs and their use in nanomedicine have received considerable attention in the last three decades, leading to the rapid development of new CD-containing formulations that significantly facilitate targeted drug delivery and controlled drug release, with consequent improvements in drug bioavailability. This MiniReview highlights the efficacy and recent uses of CDs for non-invasive drug delivery. Using ophthalmic and nasal drug delivery as examples, an overview of chemical properties, mechanisms of CDs on drug solubilization, stabilization and permeation, along with their toxicological profiles relevant to nasal and ocular administration, are provided and discussed. The recent development and application of CD-based nanocarrier systems for targeted drug delivery are summarized.Cyclodextrins (CDs) are natural cyclic oligosaccharides that are produced by enzymatic degradation of starch. There are three native CDs designated aCD, bCD and cCD, which are composed of 6, 7 and 8 D-glucopyranose units linked by a-(1, 4) glycosidic, respectively [1]. The molecules are commonly described as truncated cone, bucket-like or donut-shaped, with a hydrophilic outer surface and a relatively hydrophobic inner cavity that allows entrapment of small hydrophobic drug molecules or hydrophobic moieties of larger molecules [2], thereby providing drugs with new physicochemical characteristics without altering their intrinsic properties. Table 1 summarizes the characteristics of different CDs. Natural CDs are preferred for complexation; however, their usability is limited by the small cavity size of aCD, poor aqueous solubility of bCD and low productivity of cCD [3]. Derivatized CDs can be obtained by substituting their hydroxyl groups with desired functional moieties. Methyl-(MebCD and MecCD) [4,5], hydroxypropyl-(HPaCD, HPbCD and HPcCD) [6][7][8] and sulphobutylether (SEBbCD) derivatives [9] are frequently found in pharmaceutical products and have improved solubility and inclusion capacity over natural CDs. Pharmaceutical applications of both natural CDs and their derivatives are common when drug/CD complexes are used to increase drug solubility, improve organoleptic properties [10], enhance drug permeation [11] and increase drug stability, resulting in increased product shelf-life and drug bioavailability [12]. In addition, spontaneous self-assembly of drug/CD complexes into aggregates can lead to innovative drug delivery systems, such as CD-containing liposomes and microspheres as well as microand nanoparticles [13]. Polymerized CDs (e.g. Epi-aCD and Epi-bCD) have also been synthesized to enhance the selfassembly ability of CDs, and to strengthen their interactions with drugs and biological membranes [14]. Compared with other pharmaceutical excipients, CDs have been shown to reduce the toxicity of several drugs and are...

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Section: Cyclodextrin‐based Nanocarriers For Targeted Ocular and Nasamentioning

confidence: 94%

Section: Cmbcdmentioning

confidence: 99%

Cyclodextrin‐Based Formulations: A Non‐Invasive Platform for Targeted Drug Delivery

Muankaew

Loftsson

2017

Basic Clin Pharma Tox

165

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“…It is a lipophilic drug (Log P 1.65) with low pH-dependent aqueous solubility 0.5-0.71 mg/mL at neutral pH (maximum 2.7 mg/mL at pH 1.2). 11 VRC is classified as a BCS class II (Biopharmaceutics Classification System), 12 highly potent drug at a concentration ≤1 mg⁄ L against resistant fungal species including Fusarium, Scedosporium apiospermum, Cryptococcus neoformans, Coccidioides, Blastomyces, Histoplasma, fluconazole-resistant Candida species. Moreover, it has now become the prime treatment for aspergillosis associated with keratitis.…”

Section: Introductionmentioning

confidence: 99%

<p>Ocular Inserts of Voriconazole-Loaded Proniosomal Gels: Formulation, Evaluation and Microbiological Studies</p>

El-Emam¹,

Girgis²,

El‐Sokkary³

et al. 2020

IJN

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Background: Voriconazole (VRC) is a triazole broad spectrum antifungal drug, used in the management of versatile fungal infections, particularly fungal keratitis. The obligatory use of niosomal delivery of VRC may reduce the frequency of dosing intervals resulting from its short biological half time and consequently improve patient compliance. Methods: VRC loaded proniosomes (VRC-PNs) were set by the coacervation technique and completely characterized. The developed formula was comprehensively assessed concerning in-vitro release behavior, kinetic investigation, and its conflict against refrigerated and room temperature conditions. A selected noisomal formula was incorporated into ocusert (VRC-PNs Ocu) formulated by 1% w/w hydroxypropyl methyl cellulose HPMC and 0.1% w/w carbopol 940. Eventually, in vitro antifungal activity against Candida albicans and Aspergillus nidulans was assessed by the cup diffusion method. Results: The optimized VRC-PNs (Pluronic F127: cholesterol weight ratio 1:1 w/w) exhibited the highest entrapment efficiency (87.4±2.55%) with a spherical shape, proper size in nano range and a suitable Zeta potential of 209.7±8.13 nm and −33.5±1.85 mV, respectively. Assurance of drug encapsulation in nanovesicles was accomplished by several means such as attenuated total reflection Fourier-transform infrared spectroscopy, differential scanning calorimetry in addition to powder X-ray diffraction investigations. It displayed a biphasic in vitro release pattern and after 6 months of storage at a refrigerated temperature, the optimized formula preserved its stability. VRC-PNs Ocu proved a very highly significant antifungal activity matched with the free drug or nanosuspension which was extra assured by comparing its mean inhibition zone with that of 5% natamycin market eye drops. Conclusion: In conclusion, VRC-PNs Ocu could be considered as a promising stable sustained release topical ocular nanoparticulate system for the management of fungal infections.

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“…Compared with a voriconazole free state solution, the nanofibers significantly prolonged the antibiotic half-life and increased its bioavailability in rabbit tears. Further, no obvious signs of irritation were detected after application in the conjunctival sac [209]. Dendrimer-based nanofibers made of polyamidoamine have also been examined as topical delivery vehicles for the glaucoma drug brimonidine tartrate.…”

Section: Topicalmentioning

confidence: 99%

Spun Biotextiles in Tissue Engineering and Biomolecules Delivery Systems

et al. 2020

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Nowadays, tissue engineering is described as an interdisciplinary field that combines engineering principles and life sciences to generate implantable devices to repair, restore and/or improve functions of injured tissues. Such devices are designed to induce the interaction and integration of tissue and cells within the implantable matrices and are manufactured to meet the appropriate physical, mechanical and physiological local demands. Biodegradable constructs based on polymeric fibers are desirable for tissue engineering due to their large surface area, interconnectivity, open pore structure, and controlled mechanical strength. Additionally, biodegradable constructs are also very sought-out for biomolecule delivery systems with a target-directed action. In the present review, we explore the properties of some of the most common biodegradable polymers used in tissue engineering applications and biomolecule delivery systems and highlight their most important uses.

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Voriconazole Composited Polyvinyl Alcohol/Hydroxypropyl-β-Cyclodextrin Nanofibers for Ophthalmic Delivery

Cited by 68 publications

References 42 publications

Cyclodextrin‐Based Formulations: A Non‐Invasive Platform for Targeted Drug Delivery

Cyclodextrin‐Based Formulations: A Non‐Invasive Platform for Targeted Drug Delivery

<p>Ocular Inserts of Voriconazole-Loaded Proniosomal Gels: Formulation, Evaluation and Microbiological Studies</p>

Spun Biotextiles in Tissue Engineering and Biomolecules Delivery Systems

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