Vortioxetine, but not escitalopram or duloxetine, reverses memory impairment induced by central 5-HT depletion in rats: Evidence for direct 5-HT receptor modulation

Vortioxetine: a review of efficacy, safety and tolerability with a focus on cognitive symptoms in major depressive disorder

“…In several studies, rats were treated with a tryptophan hydroxylase inhibitor in order to deplete central 5-HT and consequently impair cognition. Vortioxetine demonstrated a reversal of this induced impairment in rats as assessed by the novel object recognition and Y-maze spontaneous alteration (spatial memory) tests [33,34]. The SSRI escitalopram and SNRI duloxetine, however, did not reverse any deficits [34].…”

“…Vortioxetine demonstrated a reversal of this induced impairment in rats as assessed by the novel object recognition and Y-maze spontaneous alteration (spatial memory) tests [33,34]. The SSRI escitalopram and SNRI duloxetine, however, did not reverse any deficits [34]. Further, the beneficial effects in the object recognition task were maintained with chronic vortioxetine administration, but no improvement was noted in performance in the spontaneous alternation test [33].…”

Reversal of age-associated cognitive deficits is accompanied by increased plasticity-related gene expression after chronic antidepressant administration in middle-aged mice

“…* indicates significant difference between vortioxetine and vehicle groups (p b 0.05), + indicates significant (p b 0.05) difference between vortioxetine and fluoxetine groups following a significant (p b 0.05) Wilcoxon/Kruskal-Wallis test (non-parametric equivalent of one-way ANOVA).^indicates non-significant difference between vortioxetine and fluoxetine (p values shown in graph). Jensen et al, 2014;Li et al, 2013) in these middle-aged mice. First, vortioxetine improved visuospatial memory while fluoxetine was not effective.…”

Determination of vortioxetine in human serum and saliva samples by HPLC–DAD and HPLC–MS

“…Vortioxetine prevented the effect of stress on hippocampal long-term potentiation (LTP), rapidly increased hippocampal cell proliferation, and enhanced short-term episodic memory, via, at least in part, its 5-HT3 receptor antagonism [7]. Patients suffering from major depressive disorder often present clinically significant cognitive dysfunction such as impaired executive function, episodic memory, and spatial working memory [3]. Bétry et al concluded that vortioxetine prevented the effect of stress on hippocampal LTP, rapidly increased hippocampal cell proliferation and enhanced short-term episodic memory, via, at least in part, its 5-HT3 receptor antagonism [7].…”

“…Vortioxetine is a multimodal antidepressant currently under development for the treatment of major depressive disorder, and is a 5-HT3A, 5-HT7, and 5-HT1D receptor antagonist; 5-HT1B receptor partial agonist; 5-HT1A receptor agonist; and 5-HTT inhibitor as measured in recombinant cell lines expressing these human 5-HT receptors and 5-HT transporter [2][3][4][5][6]. Vortioxetine prevented the effect of stress on hippocampal long-term potentiation (LTP), rapidly increased hippocampal cell proliferation, and enhanced short-term episodic memory, via, at least in part, its 5-HT3 receptor antagonism [7].…”