Voxel- and ROI-based statistical analyses of PET parameters for guidance in the surgical treatment of intractable mesial temporal lobe epilepsy

Abstract

Positron emission tomography measurement of FDG uptake was most sensitive in detecting the side of the epileptic focus. On the other hand, SPM analysis of the DV of FMZ was the most sensitive method for delineating the actual epileptic focus.

Voxel-Based Quantitative Analysis of Brain Images From 18F-FDG PET With a Block-Matching Algorithm for Spatial Normalization

“…[3][4][5] However, these methodological conditions are likely to worsen the ability to detect small foci. This point is illustrated herein by the inability of the SPM method to detect small simulated foci when using a conventional image pretreatment with a 16-mm Gaussian filter and a large cluster size of 50 voxels.…”

“…V oxel-based quantitative analysis software, such as statistical parametric mapping (SPM), is helpful for the analysis of brain images from 18 F fluorodeoxyglucose positron emission tomography (FDG PET), especially in the preoperative workup of epileptic patients [1][2][3][4][5][6][7][8][9][10] and in the presence of extratemporal foci. 11 It allows comparing each voxel value with the corresponding value obtained in a reference normal population, after an initial spatial normalization is performed to align all images to a standard anatomic model (the template).…”

PET Imaging of ¹⁸F-FDG, ¹¹C-methionine, ¹¹C-flumazenil, and ¹¹C-4DST in Progressive Multifocal Leukoencephalopathy

“…First, the 18 F-FDG uptake decreased in the gray and white matter, whereas the 11 C-flumazenil uptake decreased almost exclusively in the gray matter. Second, as is often observed in patients with epilepsy, the area of hypometabolism extended beyond the focus zone to its neighborhood, whereas the area of lost neuronal integrity localized to the focus zone (9). The 11 C-methionine uptake tended to increase in the PML legions (Fig.…”

A Review of Epilepsy Diagnosis Using PET Parameters

“…standardized uptake value (SUV) measurement), to full kinetic analysis with compartmental modeling (e.g. nonlinear regression analysis (NLR)) [42].…”