Voxel-Based Morphometry and Diffusion Tensor Imaging of the Optic Pathway in Primary Open-Angle Glaucoma: A Preliminary Study

Zikou, Anastasia; Kitsos, George; Tzarouchi, Loukia; Astrakas, Loukas G.; Alexiou, George Α.; Argyropoulou, Maria I.

doi:10.3174/ajnr.a2714

Cited by 104 publications

(111 citation statements)

References 28 publications

(53 reference statements)

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“…Noise and lesion induced cochlear damage produces downstream changes in morphology throughout the rat and cat auditory systems (Powell and Erulkar 1962;Groschel et al 2010;Coordes et al 2012) and causes changes in tonotopic representation in macaque cortex (Rajan and Irvine 1998;Kakigi et al 2000). This type of damage is similar to transsynaptic degeneration effects observed in the visual system (Minkowski 1913;Johnson and Cowey 2000;Zikou et al 2012). The elevated CSF in auditory cortex among people with high frequency hearing loss (Fig.…”

Section: Discussionsupporting

confidence: 49%

Auditory Cortex Signs of Age-Related Hearing Loss

Eckert

Cute

Vaden

et al. 2012

JARO

190

157

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Age-related hearing loss, or presbyacusis, is a major public health problem that causes communication difficulties and is associated with diminished quality of life. Limited satisfaction with hearing aids, particularly in noisy listening conditions, suggests that central nervous system declines occur with presbyacusis and may limit the efficacy of interventions focused solely on improving audibility. This study of 49 older adults (M069.58, SD08.22 years; 29 female) was designed to examine the extent to which low and/or high frequency hearing loss was related to auditory cortex morphology. Low and high frequency hearing constructs were obtained from a factor analysis of audiograms from these older adults and 1,704 audiograms from an independent sample of older adults. Significant region of interest and voxel-wise gray matter volume associations were observed for the high frequency hearing construct. These effects occurred most robustly in a primary auditory cortex region (Te1.0) where there was also elevated cerebrospinal fluid with high frequency hearing loss, suggesting that auditory cortex atrophies with high frequency hearing loss. These results indicate that Te1.0 is particularly affected by high frequency hearing loss and may be a target for evaluating the efficacy of interventions for hearing loss.

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Section: Discussionsupporting

confidence: 49%

Auditory Cortex Signs of Age-Related Hearing Loss

Eckert

Cute

Vaden

et al. 2012

JARO

190

157

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“…9 Moreover, a iovs.arvojournals.org j ISSN: 1552-5783 clinicopathologic case in humans highlighted a neural degeneration in intracranial optic nerve, lateral geniculate nucleus, and visual cortex. 10 This paradigmatic shift is further supported by several other small-sized clinical studies using brain magnetic resonance imaging (MRI), showing reduced volume of all the visual pathways (optic tracts, optic chiasm, lateral geniculate nucleus, optic radiations) measured at 1.5T [11][12][13] or 3.0T field strength. 14,15 Some other experimental studies may help understand the pathogenesis of the disease.…”

mentioning

confidence: 56%

Optic Radiations Microstructural Changes in Glaucoma and Association With Severity: A Study Using 3Tesla-Magnetic Resonance Diffusion Tensor Imaging

Tellouck

Durieux

Coupé

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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Citation: Tellouck L, Durieux M, Coupé P, et al. Optic radiations microstructural changes in glaucoma and association with severity: a study using 3Tesla-magnetic resonance diffusion tensor imaging. Invest Ophthalmol Vis Sci. 2016;57:6539-6547. DOI:10.1167/iovs.16-19838 PURPOSE. To compare microstructural changes along the optical radiations and brain structure volumes between glaucoma and control subjects using in vivo magnetic resonance imaging and to analyze their association with severity of the disease. METHODS.A total of 50 open-angle glaucoma subjects and 50 healthy age-and sex-matched controls underwent detailed ophthalmologic examinations (including visual field testing [VF], funduscopy, and spectral-domain optical coherence tomography) as well as diffusion tensor imaging (DTI) using 3.0-Tesla magnetic resonance imaging. Fractional anisotropy (FA), mean diffusivity, radial diffusivity (RD), and axial diffusivity (AD) were quantified semiautomatically along the optical radiations. DTI parameters and volumes of specific brain structures were compared between cases and controls using conditional logistic regression. Association between DTI metrics and the severity of the disease was studied using linear mixed regression analyses. RESULTS.In glaucoma subjects, optic radiations FA was significantly lower (0.57 vs. 0.59; P ¼ 0.02) and RD was significantly higher (52.78 10 -5 mm 2 /s vs. 49.74 10 -5 mm 2 /s; P ¼ 0.03) than in controls. Optic radiations FA was significantly correlated with homolateral functional and structural damage of glaucoma (mean deviation of VF [P ¼ 0.03], retinal nerve fiber layer thickness [P ¼ 0.03], vertical cup to disc ratio [P ¼ 0.0007]). Volume and DTI parameters of other brain structures (including hippocampus) were not significantly different between glaucoma patients and controls.CONCLUSIONS. We evidenced microstructural modifications along visual pathways of glaucoma patients and these alterations were correlated with disease severity. The association of glaucoma with other neurodegenerative alterations would need further exploration and a prospective follow-up of our cohort of subjects. (ClinicalTrials.gov number, NCT01621841).

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“…A chronic insult to the anterior visual pathways has been previously reported in humans to cause voxel-based changes in the primary visual cortex in the context of glaucoma. 31 The rational underpinning of these findings is Voxel-based morphometric analysis of differences in brain gray matter attenuation between the MoMHR and THA groups, after exclusion of patients with primary ocular pathology. The top panel highlights occipital cortex differences between groups; the bottom panel highlights differences in basal ganglia between groups.…”

Section: Discussionmentioning

confidence: 99%

Brain Structure and Function in Patients after Metal-on-Metal Hip Resurfacing

Clark¹,

Prentice²,

Hoggard

et al. 2014

American Journal of Neuroradiology

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BACKGROUND AND PURPOSE:Hip prostheses that use a metal-on-metal articulation expose the brain to elevated metal concentrations that, in acute excess due to prosthesis malfunction, is associated with neurologic damage, including visual and hearing loss and motor deficits. Here, we examined whether chronic exposure to lower elevated metal levels, typical of well-functioning prostheses, also affects brain structure and function.

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Voxel-Based Morphometry and Diffusion Tensor Imaging of the Optic Pathway in Primary Open-Angle Glaucoma: A Preliminary Study

Abstract: BACKGROUND AND PURPOSE:Neuropathologic studies in experimental and human glaucoma have demonstrated degenerative changes in the optic pathway. The purpose of this study was to assess the optic pathway in POAG by using VBM and DTI.

Cited by 104 publications

References 28 publications

Auditory Cortex Signs of Age-Related Hearing Loss

Auditory Cortex Signs of Age-Related Hearing Loss

Optic Radiations Microstructural Changes in Glaucoma and Association With Severity: A Study Using 3Tesla-Magnetic Resonance Diffusion Tensor Imaging

Brain Structure and Function in Patients after Metal-on-Metal Hip Resurfacing

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