Voxel-based morphometry evaluation of patients with photosensitive juvenile myoclonic epilepsy

Lin, Kátia; Jackowski, Andrea Parolin; Carrete, Henrique; Filho, Gerardo Maria de Araújo; Silva, Henrique Hattori; Guaranha, Mirian Salvadori Bittar; Guilhoto, Laura Maria de Figueiredo Ferreira; Bressan, Rodrigo A.; Yacubian, Elza Márcia Targas

doi:10.1016/j.eplepsyres.2009.05.016

Cited by 51 publications

(61 citation statements)

References 44 publications

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“…Previously reported extrafrontal changes were found in the occipital lobes of patients with JME, and then only in those who were photosensitive. 28 Though the structural changes may not overlap with previous VBM studies, the anatomic changes show a plausible relationship with the neuropsychological changes in the same group. Values of FA underlying the SMA predicted scores on the naming task and a combination of FA and gray matter volume values predicted scores on the trail making task.…”

Section: Neuropsychological and Brain Region Relationshipsmentioning

confidence: 74%

Focal structural changes and cognitive dysfunction in juvenile myoclonic epilepsy

O’Muircheartaigh¹,

Vollmar²,

Barker³

et al. 2011

Neurology

155

148

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Objective: The aim of this study was to determine if there were focal cortical abnormalities in juvenile myoclonic epilepsy (JME) using neuropsychological investigations and MRI. Methods:Twenty-eight patients with JME and a large sample of healthy controls were assessed using a series of neuropsychological tests as well as structural and diffusion tensor MRI (DTI). DTI measures assessed fractional anisotropy (FA) within a white matter skeleton.Results: Neuropsychological testing indicated subtle dysfunctions in verbal fluency, comprehension, and expression, as well as nonverbal memory and mental flexibility. Utilizing whole-brain voxel-based morphometry for gray matter MRI data and tract-based spatial statistics for white matter diffusion MRI data, we found reductions in gray matter volume (GMV) in the supplementary motor area and posterior cingulate cortex and reductions in FA in underlying white matter of the corpus callosum. Supplementary motor area FA predicted scores in word naming tasks and expression scores. Posterior cingulate cortex GMV and FA predicted cognitive inhibition scores on the mental flexibility task. Conclusions:The neuropsychological, structural, and tractography results implicate mesial frontal cortex, especially the supplementary motor area, and posterior cingulate cortex in JME. Juvenile myoclonic epilepsy (JME) is a common type of idiopathic generalized epilepsy (IGE), accounting for approximately 4%-11% of all epilepsies. It is characterized by an age-specific onset of epilepsy with myoclonic jerks, generalized tonic-clonic seizures, and, less frequently, absences. 1A typical abnormality detected by EEG is bilateral spike or polyspike and wave complexes, often strongest in frontocentral areas.2 Further focal or asymmetric abnormalities on EEG occur in approximately 30% of patients. 3,4 Fifty years ago patients with JME were noted to have personality traits previously considered to characterize frontal lobe pathology.5 Studies examining neuropsychological aspects have identified a range of deficits, for example impaired performance on tasks of mental flexibility and cognitive speed. 6 More recently, further impairments in executive functions have been highlighted. 7-10

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Section: Neuropsychological and Brain Region Relationshipsmentioning

confidence: 74%

Focal structural changes and cognitive dysfunction in juvenile myoclonic epilepsy

O’Muircheartaigh¹,

Vollmar²,

Barker³

et al. 2011

Neurology

155

148

View full text Add to dashboard Cite

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“…Other publications of the same site investigated 60 JME patients (19 with photosensitivity). The authors observed more diffuse abnormalities and a different pattern of topographical involvement between JME with and without photosensitivity [76].…”

Section: Juvenile Myoclonic Epilepsymentioning

confidence: 96%

Voxel-based morphometry and epilepsy

Yasuda

Betting

Cendes

2010

Expert Review of Neurotherapeutics

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Voxel-based morphometry is an automated technique for MRI analyses, developed to study differences in brain morphology and frequently used to study patients with diverse disorders. In epilepsy, it has been used to investigate areas with reduction or increase of gray and white matter, in different syndromes (i.e., temporal lobe epilepsy, focal cortical dysplasia and generalized epilepsies). In temporal lobe epilepsy, voxel-based morphometry showed gray/white matter atrophy extending beyond the atrophic hippocampus. These widespread abnormalities have been associated with seizure frequency, epilepsy duration, incidence of precipitating factors, cognitive dysfunction and surgical outcome. In generalized epilepsies, gray matter abnormalities were identified mainly in the thalamus and frontal cortex, reinforcing the role of the thalamocortical network in the mechanisms of generalized seizures.

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“…Thalamic volumes in IGE patients have been shown to be decreased (Bernhardt et al, 2009; Lin et al, 2009; Kim et al, 2014; Chan et al, 2006; Ciumas and Savic, 2006), increased (Betting et al, 2006) or normal (Bernasconi et al, 2003; Natsume et al, 2003). Similarly, cortical thickness or volume in IGE has been shown to be increased (Lin et al, 2009; Kim et al, 2007; Biswal et al, 2010), decreased (Bernhardt et al, 2009) or normal (Bernasconi et al, 2003; Natsume et al, 2003). To a degree, these variable findings may be explained by the use of different sample sizes and different methodologies such as voxel based or deformation-based morphometry, or manual tracing.…”

Section: Introductionmentioning

confidence: 99%

Functional neuroimaging abnormalities in idiopathic generalized epilepsy

McGill

Devinsky

Wang

et al. 2014

NeuroImage: Clinical

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Magnetic resonance imaging (MRI) techniques have been used to quantitatively assess focal and network abnormalities. Idiopathic generalized epilepsy (IGE) is characterized by bilateral synchronous spike–wave discharges on electroencephalography (EEG) but normal clinical MRI. Dysfunctions involving the neocortex, particularly the prefrontal cortex, and thalamus likely contribute to seizure activity. To identify possible morphometric and functional differences in the brains of IGE patients and normal controls, we employed measures of thalamic volumes, cortical thickness, gray–white blurring, fractional anisotropy (FA) measures from diffusion tensor imaging (DTI) and fractional amplitude of low frequency fluctuations (fALFF) in thalamic subregions from resting state functional MRI. Data from 27 patients with IGE and 27 age- and sex-matched controls showed similar thalamic volumes, cortical thickness and gray–white contrast. There were no differences in FA values on DTI in tracts connecting the thalamus and prefrontal cortex. Functional analysis revealed decreased fALFF in the prefrontal cortex (PFC) subregion of the thalamus in patients with IGE. We provide minimum detectable effect sizes for each measure used in the study. Our analysis indicates that fMRI-based methods are more sensitive than quantitative structural techniques for characterizing brain abnormalities in IGE.

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Voxel-based morphometry evaluation of patients with photosensitive juvenile myoclonic epilepsy

Cited by 51 publications

References 44 publications

Focal structural changes and cognitive dysfunction in juvenile myoclonic epilepsy

Focal structural changes and cognitive dysfunction in juvenile myoclonic epilepsy

Voxel-based morphometry and epilepsy

Functional neuroimaging abnormalities in idiopathic generalized epilepsy

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