Voxel-Based Morphometry Reveals a Correlation Between Bone Mineral Density Loss and Reduced Cortical Gray Matter Volume in Alzheimer’s Disease

Takano, Yoshinao; Tatewaki, Yasuko; Mutoh, Tatsushi; Morota, Naoya; Matsudaira, Izumi; Thyreau, Benjamin; Nagasaka, Tatsuo; Odagiri, Hayato; Yamamoto, Shinjiro; Arai, Hiroyuki; Taki, Yasuyuki

doi:10.3389/fnagi.2020.00178

Cited by 12 publications

(5 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further, we calculated the ASL data using the AW4.6 GE workstation to calculate the CBF map. Using the SPM8 software package applied in MATLAB, we initially registered the CBF image of each participant to their T1 image, normalized it to the standard brain, and lastly adopted an 8-mm isotropic Gaussian kernel for smoothing ( Takano et al, 2020 ).…”

Section: Methodsmentioning

confidence: 99%

The correlation of retinal neurodegeneration and brain degeneration in patients with Alzheimer’s disease using optical coherence tomography angiography and MRI

Zhao

Yan

et al. 2023

Front. Aging Neurosci.

View full text Add to dashboard Cite

IntroductionPathological changes in Alzheimer’s disease can cause retina and optic nerve degeneration. The retinal changes are correlated with cognitive function. This study aimed to explore the relationship of retinal differences with neuroimaging in patients with Alzheimer’s disease, analyze the association of cognitive function with retinal structure and vascular density, and identify potential additional biomarkers for early diagnosis of Alzheimer’s disease.MethodWe performed magnetic resonance imaging (MRI) scans and neuropsychological assessments in 28 patients with mild Alzheimer’s disease and 28 healthy controls. Retinal structure and vascular density were evaluated by optical coherence tomography angiography (OCTA). Furthermore, we analyzed the correlation between neuroimaging and OCTA parameters in patients with mild Alzheimer’s disease with adjustment for age, gender, years of education, and hypertension.ResultsIn patients with mild Alzheimer’s disease, OCTA-detected retinal parameters were not significantly correlated with MRI-detected neuroimaging parameters after Bonferroni correction for multiple testing. Under multivariable analysis controlled for age, gender, years of education, and hypertension, the S-Hemi (0–3) sector of macular thickness was significantly associated with Mini-cog (β = 0.583, P = 0.002) with Bonferroni-corrected threshold at P < 0.003.ConclusionOur findings suggested decreased macular thickness might be associated with cognitive function in mild AD patients. However, the differences in retinal parameters didn’t correspond to MRI-detected parameters in this study. Whether OCTA can be used as a new detection method mirroring MRI for evaluating the effect of neuronal degeneration in patients with mild Alzheimer’s disease still needs to be investigated by more rigorous and larger studies in the future.

show abstract

Section: Methodsmentioning

confidence: 99%

The correlation of retinal neurodegeneration and brain degeneration in patients with Alzheimer’s disease using optical coherence tomography angiography and MRI

Zhao

Yan

et al. 2023

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

“…Prior research has indicated that bone loss is interconnected with alterations in the structure of the brain (56)(57)(58)(59)(60). We chose the DLPFC as the stimulating brain area based on the preliminary results of our clinical study of neuroimaging.…”

Section: Stimulating Location Of Intervention Modalities For Pmopmentioning

confidence: 99%

Catgut embedding in acupoints combined with repetitive transcranial magnetic stimulation for the treatment of postmenopausal osteoporosis: study protocol for a randomized clinical trial

Qiu,

Xu,

Cai

et al. 2024

Front. Neurol.

View full text Add to dashboard Cite

BackgroundTo date, the clinical modulation for bone metabolism based on the neuro-bone mass regulation theory is still not popular. The stimulation of nerve systems to explore novel treatments for Postmenopausal osteoporosis (PMOP) is urgent and significant. Preliminary research results suggested that changes brain function and structure may play a crucial role in bone metabolism with PMOP. Thus, we set up a clinical trial to investigate the effect of the combination of repetitive transcranial magnetic stimulation (rTMS) and catgut embedding in acupoints (CEA) for PMOP and to elucidate the central mechanism of this neural stimulation in regulating bone metabolism.MethodThis trial is a prospective and randomized controlled trial. 96 PMOP participants will be randomized in a 1:1:1 ratio into a CEA group, an rTMS group, or a combined one. Participants will receive CEA, rTMS, or combined therapy for 3 months with 8 weeks of follow-up. The primary outcomes will be the changes in Bone Mineral Density scores, total efficiency of Chinese Medicine Symptoms before and after treatment. Secondary outcomes include the McGill Pain Questionnaire Short-Form, Osteoporosis Symptom Score, Mini-Mental State Examination, and Beck Depression Inventory-II. The leptin, leptin receptor, and norepinephrine levels of peripheral blood must be measured before and after treatment. Adverse events that occur during the trial will be recorded.DiscussionCEA achieves brain-bone mass regulation through the bottom-up way of peripheral-central while rTMS achieves it through the top-down stimulation of central-peripheral. CEA combined with rTMS can stimulate the peripheral-central at the same time and promote peripheral bone mass formation. The combination of CEA and rTMS may play a coordinating, synergistic, and side-effect-reducing role, which is of great clinical significance in exploring better treatment options for PMOP.Clinical trial registration: https://www.chictr.org.cn/, identifier ChiCTR2300073863.

show abstract

“…In particular, it is hypothesized that the “bone-brain crosstalk” relies on the secretion of some osteoblast-derived molecules from the bone to the blood that, in turn, can influence the brain development and normal function of the central nervous system if they pass the blood-brain barrier [ 18 , 19 ]. In addition, previous studies provide evidence that a link between BMD values (being measured by dual-energy X-ray absorptiometry [DXA]) and whole-brain volume (being measured by magnetic resonance imaging in AD) exists [ 20 , 21 ], suggesting that bone loss may play an important role in the AD-related neurodegeneration. Hence, abnormal BMD may be a potential indicator to identify participants with a high risk of AD.…”

Section: Introductionmentioning

confidence: 99%

Potential association of bone mineral density loss with cognitive impairment and central and peripheral amyloid-β changes: a cross-sectional study

Zhang

Zhou

Chen

et al. 2022

BMC Musculoskelet Disord

View full text Add to dashboard Cite

Background There is some evidence in the literature that older adults with cognitive impairments have a higher risk for falls and osteoporotic hip fractures. Currently, the associations between bone health and cognitive health have not been extensively studied. Thus, the present cross-sectional study aims to investigate the relationship between markers of bone loss and cognitive performance in older adults with and without osteopenia as well as older adults with cognitive impairments (i.e., Alzheimer’s disease [AD]). Methods Sixty-two non-osteopenia participants and one hundred three osteopenia participants as the cohort 1 and 33 cognitively normal non-AD participants and 39 AD participants as the cohort 2 were recruited. To assess cognitive and bone health, hip bone mineral density (BMD) and cognitive performance (via Minimal Mental State Examination [MMSE] and/or Auditory Verbal Learning Test-delayed recall [AVLT-DR]) were assessed. Furthermore, in cohort 1, plasma amyloid-β (Aβ) levels, and in cohort 2, cerebrospinal fluid (CSF) Aβ levels were determined. Results We observed that (1) compared with non-osteopenia participants, BMD values (t = − 22.806; 95%CI: − 1.801, − 1.484; p < 0.001), MMSE scores (t = − 5.392; 95%CI: − 3.260, − 1.698; p < 0.001), and AVLT-DR scores (t = − 4.142; 95%CI: − 2.181, − 0.804; p < 0.001), plasma Aβ42 levels (t = − 2.821; 95%CI: − 1.737, − 0.305; p = 0.01), and Aβ42/40 ratio (t = − 2.020; 95%CI: − 0.009, − 0.001; p = 0.04) were significantly lower in osteopenia participants; (2) plasma Aβ42/40 ratio showed a mediate effect for the association between BMD values and the performance of cognitive function in osteopenia participants by mediation analysis, adjusting age, sex, years of education, and body mass index (BMI); (3) BMD values (95%CI: − 1.085, 0.478; p < 0.001) were significantly reduced in AD participants as compared with cognitively normal non-AD participants; (4) in AD participants, the interactive effects of BMD and CSF Aβ42/40 ratio on MMSE scores was found by regression analysis, controlling age, sex, years of education, and BMI; (5) BMD can distinguish AD participants from cognitively normal non-AD participants with AUC of 0.816 and distinguish participants with the cognitive impairment from cognitively normal participants with AUC of 0.794. Conclusion Our findings suggest a relationship between bone health and cognitive health. Given the correlations between BMD and important markers of cognitive health (e.g., central and peripheral pathological change of Aβ), BMD might serve as a promising and easy-accessible biomarker. However, more research is needed to further substantiate our findings.

show abstract

Voxel-Based Morphometry Reveals a Correlation Between Bone Mineral Density Loss and Reduced Cortical Gray Matter Volume in Alzheimer’s Disease

Cited by 12 publications

References 31 publications

The correlation of retinal neurodegeneration and brain degeneration in patients with Alzheimer’s disease using optical coherence tomography angiography and MRI

The correlation of retinal neurodegeneration and brain degeneration in patients with Alzheimer’s disease using optical coherence tomography angiography and MRI

Catgut embedding in acupoints combined with repetitive transcranial magnetic stimulation for the treatment of postmenopausal osteoporosis: study protocol for a randomized clinical trial

Potential association of bone mineral density loss with cognitive impairment and central and peripheral amyloid-β changes: a cross-sectional study

Contact Info

Product

Resources

About