VP161 Identification Of Needs Of Pigmented Villonodular Synovitis Patients Using Online Bulletin Board

Abstract

INTRODUCTION:Pigmented villonodular synovitis (PVNS) is a very rare, benign proliferative tumor affecting the inner lining of synovial joints and tendon sheets. Information on treatment needs of PVNS patients to inform drug development is currently scarce, hence we conducted qualitative research with patients using an online bulletin board (OBB) methodology to generate insights on objective and emotional aspects related to the medical journey and living with this disease.METHODS:OBB is an asynchronous, online qualitative market research tool that allows participants to comprehensively answer pre-defined questions in a comprehensive manner. Patients were recruited via physician referral and underwent screening questions to ensure eligibility for the study and willingness to participate. The discussion was moderated, structured, and allowed open answers and in response to other participants posts. Analysis was conducted using a combination of different qualitative analytical tools.RESULTS:The patient OBB ran for 4 days with eleven participants (n = 3 Canada, n = 4 United Kingdom, n = 4 United States of America) aged 28–57 years, suffering from PVNS for 2–27 years. The key patient insights were: (i) pain is the primary factor, constituting a significant emotional and psychological burden; (ii) surgery (arthroscopy) does not get rid of PVNS, relapse rate was high in these patients; and (iii) PVNS has a big financial impact on patients, their families, and the healthcare system, due in particular to time off work/lost wages (patient & caretaker), for healthcare system it is repeat costs for surgeries/hospital stays plus other medical expenses. We also identified orthopedic specialists/surgeons are the physicians who predominantly manage PVNS at this point, as surgery is the only option.CONCLUSIONS:This study shows the suitability of the OBB for uncovering qualitative patient insights to inform decision making and strategy in early pharmaceutical drug development. OBB lends itself very well to uncovering patient insights which might not be revealed in focus group or telephone interviews, particularly in a rare disease like this. PVNS patients are in need of a medical drug treatment which can reduce pain, relapses and provide an alternative to surgery, the current standard of care.

Understanding Patient Preferences and Unmet Needs in Non-alcoholic Steatohepatitis (NASH): Insights from a Qualitative Online Bulletin Board Study

“…We have successfully applied this OBB research methodology in other disease areas that include indications ranging from chronic obstructive pulmonary disease, obesity, to even very rare conditions like pigmented villonodular synovitis [36–39]. The strength of the present study methodology was the maintenance of patient anonymity, which led to open-minded, spontaneous, and interactive responses from patients.…”

Patient Needs, Perceptions, and Attitudinal Drivers Associated with Obesity: A Qualitative Online Bulletin Board Study

“…In the contemporary digital era the use of an OBB platform provides a convenient and effective medium to derive patient insights whilst overcoming geographical restrictions. Earlier we have applied the OBB methodology in various disease areas like chronic obstructive pulmonary disease, non-alcoholic steatohepatitis, and even very rare conditions like pigmented villonodular synovitis [19, 22–24]. One of the key strengths of this methodology is that it maintains patient anonymity, which leads to open-minded, spontaneous, and interactive responses even when dealing with more sensitive topics.…”