This study developed a comprehensive framework for vulnerability assessment as a tool to measure vulnerability at three levels of geopolitical units in the Philippines. This is a comprehensive multi-disaster framework that can provide information to a decentralized type of government system like the Philippines. The vulnerability assessment framework (VAF) that has been developed was anchored upon the IPCC model and used the integration of community-based monitoring system (CBMS) data, expert inputs, and a series of community-based activities such as consultative fora, focus group discussions, workshops, and risk reduction immersion activities. The developed VAF for the assessment of vulnerability indices (VIs) is a system framework composed of a vulnerability scoping diagram (VSD) and an expanded vulnerability assessment model (VAM). The VSD is composed of three dimensions (e.g., exposure, sensitivity, resiliency), seven identified hazards, with 26, 27, and 29 sub-indicators for household, barangay, and municipal levels, respectively. Measuring vulnerability can be an effective strategy for assessing the potential impact/s of natural disasters on society. The continuous occurrence of natural disasters in the Philippines requires enhancement of public understanding of vulnerability. This would provide transparent understanding and enhance community competency leading to the development of methodologies and tools to assess various factors and indicators of vulnerability. The information extracted from using the VAF and VSD are helpful to the local government units, especially in preparing budgets, strategies, and programs for disaster risk reduction.