Vulnerability of marsh frog Pelophylax ridibundus to the typical wastewater effluents ibuprofen, triclosan and estrone, detected by multi-biomarker approach

Falfushynska, Halina; Gnatyshyna, Lesya; Horyn, Oksana; Stoliar, Оksana

doi:10.1016/j.cbpc.2017.07.004

Cited by 17 publications

(5 citation statements)

References 103 publications

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“…The results obtained for TCS in this study can be compared with other authors, such as Matozzo et al, (2012), who showed that the AChE activity present in the gills of the clam Ruditapes philippinarum decreased when individuals were exposed to TCS concentrations between 300 and 900 ng/L. Falfushynska et al, (2017) examined the possible effects of typical compounds added to PPCPs on Pelophylax ridibundus, with TCS showing the greatest inhibition of the AChE enzyme activity. In both studies, the concentrations of TCS were 106 times lower than the concentrations used in our project.…”

Section: Resultssupporting

confidence: 53%

The Effects of Exposing Solea senegalensis to Microbeads with and Without Pesticides

Albendín

Alarcón

Oviedo

et al. 2023

Water Air Soil Pollut

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Microplastics (MP) are contaminants able to cause adverse effects on organisms. MPs are capable to interact with other environmental contaminants, including pesticides, altering their toxicity. The objective of the study was to research the sublethal effects (enzymatic activity) of pesticides alone and in combination with MPs. Cholinesterase enzymes are used as biomarkers to determine and evaluate the effects produced in organisms after exposure to pollutants. This study showed the acetylcholinesterase (AChE) enzymatic activity in the tissue of Solea senegalensis exposed to two environmental pollutants, the insecticide chlorpyrifos (CPF) and antibacterial triclosan (TCS) with and without microplastics (MPs). Solea senegalensis was chosen because it is a species in high demand because of its high economic value in southern Europe, as well as the use of this species in ecotoxicology and its increasing use as sentinel species, which justify using it to assess biological effects of pollutants. Toxicity tests were performed in organisms exposed to concentrations of between 5 and 80 μg/L CPF and 0.1 and 0.4 mg/L TCS for 96 h. In addition, each test incorporated MPs that were added at different concentrations in order to evaluate their role as a possible enhancer of the effects caused by the previous pollutants. In the case of CPF, the head and muscle tissue cholinesterase activity was inhibited from a concentration of 5 μg/L both without and with MPs, and the AChE enzymatic activity for the treatment with MPs was approximately half the activity for the treatment without MPs in the tissues studied. Besides, TCS inhibited the cholinesterase activity at a concentration of 0.3 mg/L in the muscle of S. senegalensis. In contrast, no significant differences were observed in the TCS + MP treatment compared to the controls. These results showed the importance of studies in assessing the anticholinesterase effects of pesticides combined with microplastics due to the abundance of these contaminants in the marine environment and the role of cholinesterase activity (biomarker) in the neurotransmission of key physiological processes.

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Section: Resultssupporting

confidence: 53%

The Effects of Exposing Solea senegalensis to Microbeads with and Without Pesticides

Albendín

Alarcón

Oviedo

et al. 2023

Water Air Soil Pollut

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“…Studies conducted by Falfushynska et al [85] performed on Marsh frog (Pelophylax ridibundus) with utilization of 100 ng/L estrone (E1) solution have shown that wide array of indices were significantly affected. Exposure have resulted in increased levels of vitellogenin and thyrotropin in blood plasma, elevated caspase-3 level, and lowered cholinesterase activity which could imply proapoptotic activity and the level of neurotoxicity.…”

Section: Amphibiansmentioning

confidence: 99%

“…Gonadal abnormalities, reduced fertility, males mating behavior impaired, elevated levels of thyrotropin and vitellogenin in blood plasma, elevated caspase-3 level and lowered cholinesterase activity, can induce proapoptotic and anti-apoptotic activity, neurotoxicity. [5,62,85,129,133,134] Estradiol (E2)…”

Section: Estrogen Skeletal Formula Role Effects Of Toxicity Referencesmentioning

confidence: 99%

Impact of Estrogens Present in Environment on Health and Welfare of Animals

Wojnarowski

Podobiński

Cholewińska

et al. 2021

Animals

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Nowadays, there is a growing interest in environmental pollution; however, knowledge about this aspect is growing at an insufficient pace. There are many potential sources of environmental contamination, including sex hormones—especially estrogens. The analyzed literature shows that estrone (E1), estradiol (E2), estriol (E3), and synthetic ethinyloestradiol (EE2) are the most significant in terms of environmental impact. Potential sources of contamination are, among others, livestock farms, slaughterhouses, and large urban agglomerations. Estrogens occurring in the environment can negatively affect the organisms, such as animals, through phenomena such as feminization, dysregulation of natural processes related to reproduction, lowering the physiological condition of the organisms, disturbances in the regulation of both proapoptotic and anti-apoptotic processes, and even the occurrence of neoplastic processes thus drastically decreasing animal welfare. Unfortunately, the amount of research conducted on the negative consequences of their impact on animal organisms is many times smaller than that of humans, despite the great richness and diversity of the fauna. Therefore, there is a need for further research to help fill the gaps in our knowledge.

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“…Ibuprofen is a nonsteroidal anti-inflammatory and analgesic that is very frequently used by the population in general, and its high concentrations found in wastewaters in some countries (2-17 mg L −1 ) dramatically affect the environment (Thalla and Vannarath, 2020;Pereira et al, 2020). In fact, this drug causes the inhibition of photosynthesis at doses between 10 and 100 mg L −1 , and lysosomal membrane instability at much lower concentrations in frogs (250 ng L −1 ) (Ding et al, 2017;Falfushynska et al, 2017). It has been found in wastewaters from different sources and in other environmental samples (1900-16,000 ng L −1 ) (de Oliveira et al, 2020, Carretta et al, 2019, Lizano-Fallas et al, 2017.…”

Section: Effect Of Different Microalgae Consortia On the Removal Of E...mentioning

confidence: 99%

A sustainable approach by using microalgae to minimize the eutrophication process of Mar Menor lagoon

Gil‐Izquierdo

Pedreño

Montoro-García

et al. 2021

Science of The Total Environment

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Vulnerability of marsh frog Pelophylax ridibundus to the typical wastewater effluents ibuprofen, triclosan and estrone, detected by multi-biomarker approach

Cited by 17 publications

References 103 publications

The Effects of Exposing Solea senegalensis to Microbeads with and Without Pesticides

The Effects of Exposing Solea senegalensis to Microbeads with and Without Pesticides

Impact of Estrogens Present in Environment on Health and Welfare of Animals

A sustainable approach by using microalgae to minimize the eutrophication process of Mar Menor lagoon

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