Vγ9Vδ2 T cells recovered from eyes of patients with Behçet's disease recognize non-peptide prenyl pyrophosphate antigens

αβ TCR+T Cells, but Not B Cells, Promote Autoimmune Keratitis in B10 Mice Lacking γδ T Cells

“…4), have been shown to be particularly susceptible to progression to HSV infection of the brain if they lack ␥␦ T cells, 5 consistent with the idea that ␥␦ T cells normally downregulate immune responses that are evoked in the cornea and thus prevent inflammatory damage that leads to this complication. Increases in ␥␦ T cells during autoimmune disorders of the human eye have also been noted, including Behçet's disease 6 and ocular cicatricial pemphigoid, 7,8 as well as in chronic corneal graft rejection, 8 which suggests that ␥␦ T cells play a similar regulatory role in the human eye. We recently reported that, in female mice of the C57BL/10 background, which lack ␥␦ T cells because of genetic disruption of the TCR-␦ constant region (B10.TCR␦ Ϫ/Ϫ mice), keratitis develops spontaneously, such that by 18 weeks of age, 70% to 80% of adult females show evidence of disease.…”

Phenotype markers and cytokine intracellular production by CD8+ γδ T lymphocytes do not support a regulatory T profile in Behçet's disease patients and healthy controls

“…Some studies found local increases of V␦2 + cells [17,18] or V␦1 + [19] and others showed a specific increase of GDCD8+ [20,21]. Most of the works relate GD shifts to increased cytotoxicity or proliferative response to different antigens [19,22].…”

Chemokine Expression of Intraocular Lymphocytes in Patients with Behçet Uveitis

“…Accordingly, molecular mechanisms may be different in Behçet uveitis and in non-Behçet uveitis because the infiltrating intraocular inflammatory cells or cytokines are different [8,9] .…”