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MacDonald, Frank M.; Lingard, V. M.

doi:10.1007/978-1-4899-7270-5_22

Cited by 3 publications

(3 citation statements)

References 2 publications

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“…8.4.0) (26). The statistical testing of changes in gene expression of transgenic R6/1 HD mice was compared to wild-type littermates using a linear model in limma (Supplementary Table S2a).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Transcriptional profiles for distinct aggregation states of mutant Huntingtin exon 1 protein unmask new Huntington's disease pathways

Moily

Ormsby

Stojilovic

et al. 2017

Molecular and Cellular Neuroscience

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Huntington's disease is caused by polyglutamine (polyQ)-expansion mutations in the CAG tandem repeat of the Huntingtin gene. The central feature of Huntington's disease pathology is the aggregation of mutant Huntingtin (Htt) protein into micrometer-sized inclusion bodies. Soluble mutant Htt states are most proteotoxic and trigger an enhanced risk of death whereas inclusions confer different changes to cellular health, and may even provide adaptive responses to stress. Yet the molecular mechanisms underpinning these changes remain unclear. Using the flow cytometry method of pulse-shape analysis (PulSA) to sort neuroblastoma (Neuro2a) cells enriched with mutant or wild-type Htt into different aggregation states, we clarified which transcriptional signatures were specifically attributable to cells before versus after inclusion assembly. Dampened CREB signalling was the most striking change overall and invoked specifically by soluble mutant Httex1 states. Toxicity could be rescued by stimulation of CREB signalling. Other biological processes mapped to different changes before and after aggregation included NF-kB signalling, autophagy, SUMOylation, transcription regulation by histone deacetylases and BRD4, NAD+ biosynthesis, ribosome biogenesis and altered HIF-1 signalling. These findings open the path for therapeutic strategies targeting key molecular changes invoked prior to, and subsequently to, Httex1 aggregation.

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Section: Accepted Manuscriptmentioning

confidence: 99%

Transcriptional profiles for distinct aggregation states of mutant Huntingtin exon 1 protein unmask new Huntington's disease pathways

Moily

Ormsby

Stojilovic

et al. 2017

Molecular and Cellular Neuroscience

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“…Poly(ethylene terephthalate) (PET) is a commercially important polymer that finds applications in textiles, and as reinforcement fiber in tires, as well as in food and beverage packaging. 2,3 Opportunities for extending the range of PET applications include enhancing its gas barrier properties, as well as maintaining its mechanical properties at elevated temperatures. Crosslinking is potentially one of the most effective ways to improve these properties.…”

Section: Introductionmentioning

confidence: 99%

Crosslinking studies on poly(ethylene terephthalate‐co‐1,4‐phenylene bisacrylate)

Vargas

Collard

et al. 2003

J of Applied Polymer Sci

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Several compositionally different poly(ethylene terephthalate-co-1,4-phenylene bisacrylate) (PETPBA) copolymers were melt spun into fibers. The resulting fibers were subjected to UV irradiation to induce crosslinking. Evidence of crosslinking was obtained from FTIR, solid-state 13 C-NMR, thermal analysis, and solubility. Irradiation of the fiber results in an increased glass-transition temperature, reduced thermal shrinkage, and enhanced modulus retention at elevated temperature.

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“…Experts in the field feel that the mainframe of the future will not be a gigantic PC; it will be software and a network (Reinhardt, 1995). At the day-to-day level, organizations continue to report pressure for full network connectivity and associated services such as e-mail from users (MacDonald, Wood, & Behling, 1993). The result of these trends is that there is a continuing demand for access to networked computer resources.…”

mentioning

confidence: 99%

Computer Use Patterns

Lundgren

1996

Journal of Organizational and End User Computing

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Cited by 3 publications

References 2 publications

Transcriptional profiles for distinct aggregation states of mutant Huntingtin exon 1 protein unmask new Huntington's disease pathways

Transcriptional profiles for distinct aggregation states of mutant Huntingtin exon 1 protein unmask new Huntington's disease pathways

Crosslinking studies on poly(ethylene terephthalate‐co‐1,4‐phenylene bisacrylate)

Computer Use Patterns

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