W Tungsten

Jehn, Hermann; Gmünd, Schwäbisch; Bär, Gudrun; Best, Erich; Koch, Ernst

doi:10.1007/978-3-662-08684-1

Cited by 5 publications

(5 citation statements)

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“…Collectively, studies on various vertebrate models of neurogenesis, myogenesis and haematopoiesis suggest that Notch signalling inhibits or delays differentiation along a developmental pathway until the cell is able to respond appropriately to inductive signal(s) that ultimately determine its fate (7-10). Studies in thymocyte development and haematopoiesis suggest that Notch signalling can promote cell survival and affect cell cycle progression 216 Immunological Reviews 182/2001 (11)(12)(13). Notch signalling is also required later in neurogenesis, where it controls two other aspects of neural development: promoting the differentiation of glial cells and regulating neurite arbourisation (14)(15)(16).…”

Section: Notch Signallingmentioning

confidence: 99%

“…CD8 π T cells can also give rise to distinct subsets that display polarised patterns of cytokine secretion and are designated as Tc1 or Tc2 cells. There is evidence that Notch signalling in mature T-cell lines and thymocytes can protect them from AICD as a result of TCR triggering (11,12). Although this protection was originally proposed to be mediated by Notch1, recent studies using Notch1 conditional mutant cells demonstrate that this cannot be the case.…”

Section: Notch and The Peripheral Immune Systemmentioning

confidence: 99%

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Notch signalling in the regulation of peripheral immunity

Hoyne

Dallman

Champion³

et al. 2001

Immunological Reviews

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Notch signalling plays a critical role in embryogenesis, influencing the differentiation and growth of a variety of cell types across the species. In the mammalian immune system, Notch signalling operates at various levels; it controls the differentiation of haematopoietic stem cells and directs the early development of the T and B-cell lineages. It is also involved in the maturation of both CD4+ and CD8+ T cells in the thymus. The biological activities of this pathway extend beyond lymphocyte ontogeny; recent evidence has shown that it also contributes to the regulation of the peripheral immune system through its ability to influence cell survival and growth. In fulfilling this function, Notch signalling appears to act in conjunction with defined immunological signals such as cytokines, T-cell antigen receptor and co-stimulatory receptor-mediated signalling. In this review we discuss the potential of the Notch signalling pathway in the maintenance of homeostasis within the immune system affecting both peripheral tolerance and the negative feedback controlling productive immunity. The therapeutic manipulation of this pathway is likely to have broad application in a range of immunologically based diseases.

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Section: Notch Signallingmentioning

confidence: 99%

Section: Notch and The Peripheral Immune Systemmentioning

confidence: 99%

Notch signalling in the regulation of peripheral immunity

Hoyne

Dallman

Champion³

et al. 2001

Immunological Reviews

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“…Inhibition of apoptosis by Notch-1 has been seen in several models Shelly et al, 1999;Zlobin et al, 2000;Rangarajan et al, 2001a). Induction of NF-kB (Cheng et al, 2001), inhibition of JNK Zecchini et al, 1999), inactivation of Nur77 (Jehn et al, 1999) and activation of PKB/AKT (Rangarajan et al, 2001a) have been suggested to mediate these survival signals. Notch-3 can induce antiapoptotic protein c-FLIP via ERK (Wang et al, 2002).…”

mentioning

confidence: 99%

Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents

2003

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“…The accumulated silicon diffuses inside the filament bulk. However, since the diffusion coefficient of silicon in tungsten is extremely low cm 2 /s , about 10 4 times smaller than the diffusion coefficient in the silicided compound [19], Si atoms are accumulating just within a small distance from the surface of the filament (9) By solving the diffusion problem [20] for the fulfilled limits and , it is found that the beginning of the macroscopic W 5 Si 3 precipitation…”

Section: Resultsmentioning

confidence: 99%

Degradation of thin tungsten filaments at high temperature in HWCVD

2015

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The degradation of the filaments is usually studied by checking the silicidation or carbonization status of the refractory metal used as catalysts, and their effects on the structural stability of the filaments. In this paper, it will be shown that the catalytic stability of a filament heated at high temperature is much shorter than its structural lifetime. The electrical resistance of a thin tungsten filament and the deposition rate of the deposited thin film have been monitored during the filament aging. It has been found that the deposition rate drops drastically once the quantity of dissolved silicon in the tungsten reaches the solubility limit and the silicides start precipitating. This manuscript concludes that the catalytic stability is only guaranteed for a short time and that for sufficiently thick filaments it does not depend on the filament radius.

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W Tungsten

Cited by 5 publications

References 0 publications

Notch signalling in the regulation of peripheral immunity

Notch signalling in the regulation of peripheral immunity

Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents

Degradation of thin tungsten filaments at high temperature in HWCVD

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