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Abdullin, I. F.; Chernysheva, N. N.; Будников, Г. К.

doi:10.1023/a:1016238319963

Cited by 17 publications

(6 citation statements)

References 2 publications

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“…Owing to concerns over the electroanalytical determination of sulfa drugs, methods using both oxidation [16][17][18][19][20][21][22][23] and reduction [24][25][26][27][28][29][30] reactions have been reported. Sulfadiazine (4-amino-N-2-pyrimidinylbenzenesulfonamide), together with sulfamethoxazole, is the sulfonamide antibiotic most used in human and veterinary medicine.…”

Section: Introductionmentioning

confidence: 99%

Application of bismuth-film electrode for cathodic electroanalytical determination of sulfadiazine

Campestrini

Braga

Vieira

et al. 2010

Electrochimica Acta

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Section: Introductionmentioning

confidence: 99%

Application of bismuth-film electrode for cathodic electroanalytical determination of sulfadiazine

Campestrini

Braga

Vieira

et al. 2010

Electrochimica Acta

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“…Another area where calibration free coulometric titrators have been of interest is for the determination of drugs in pharmaceutical preparations by galvanostatic bromine generation, for instance. 9 There are two key challenges associated with coulometric reagent delivery: a limited selectivity and a limited choice of reagents that can be released in such a manner. Redox reactions at metal electrodes are normally not perfectly selective, especially in complex and unknown samples.…”

Section: Introductionmentioning

confidence: 99%

Selective coulometric release of ions from ion selective polymeric membranes for calibration-free titrations

Bhakthavatsalam

Shvarev

Bakker

2006

Analyst

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Coulometry belongs to one of the few known calibration-free techniques and is therefore highly attractive for chemical analysis. Titrations performed by the coulometric generation of reactants is a well-known approach in electrochemistry, but suffers from limited selectivity and is therefore not generally suited for samples of varying or unknown composition. Here, the selective coulometric release of ionic reagents from ion-selective polymeric membrane materials ordinarily used for the fabrication of ion-selective electrodes is described. The selectivity of such membranes can be tuned to a significant extent by the type and concentration of ionophore and lipophilic ion-exchanger and is today well understood. An anodic current of fixed magnitude and duration may be imposed across such a membrane to release a defined quantity of ions with high selectivity and precision. Since the applied current relates to a defined ion flux, a variety of non-redox active ions may be accurately released with this technique. In this work, the released titrant's activity was measured with a second ionophore-based ion-selective electrode and corresponded well with expected dosage levels on the basis of Faraday's law of electrolysis. Initial examples of coulometric titrations explored here include the release of calcium ions for complexometric titrations, including back titrations, and the release of barium ions to determine sulfate.

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“…Sulfa drugs such as sulfanilamide (86), sulfaguanidine (112a), sulfacetamide (112b), sulfaethidole (112c) and sulfamethoxazole (100) undergo 1:2 reactions with electrochemically generated Br 2 ; sulfathiazole (101) shows a 1:4 stoichiometry because, in addition to the benzene ring double bromination, the thiazole group undergoes oxidation to thiazole N-oxide (113). Determination of such drugs in pharmaceutical preparations had RSD of 5% or lower 227 .…”

Section: Electrochemical Methodsmentioning

confidence: 99%