• ▶ polycystic ovary syndrome • ▶ metabolic syndrome • ▶ lipid accumulation product Lipid Accumulation Product is Related to Metabolic Syndrome in Women with Polycystic Ovary Syndrome are exposed to risk factors at a younger age [ 9 ] . Early and accurate identifi cation of high-risk individuals for MS could be important to predict and prevent CVD and type 2 diabetes. There is, therefore, an urgent need to develop a simple, accurate and economic predictor for MS in PCOS. The lipid accumulation product (LAP), which was fi rst described by Kahn [ 10 ] , is based on a combination of waist circumference (WC) and serum triglycerides (TG) and serves as a simple index for lipid over accumulation in adults. High levels of LAP are associated with CVD, impaired glucose tolerance (IGT) and type 2 diabetes [ 11 , 12 ] . In healthy population, LAP is a powerful marker of MS [ 13 , 14 ] , however, to the best of our knowledge, there is currently limited research on the relationship between LAP and MS in women with PCOS. Thus, we aim to investigate the ability of LAP to identify MS in PCOS patients. . It is characterized by hyperandrogenemia, chronic anovulation, and polycystic ovary morphology [ 2 , 3 ] .The etiology of PCOS is still not very clear, however, previous studies have shown that insulin resistance (IR) and central obesity are key pathological factors of PCOS [ 4 , 5 ] . PCOS is not only the reproductive endocrine disease, but also metabolic disorder. Patients with PCOS are often accompanied by metabolic abnormalities, such as dyslipidemia, obesity, and glucose intolerance, which are also components of the metabolic syndrome (MS) [ 6 ] . MS is a cluster of metabolic disorders associated with increased risk of cardiovascular disease (CVD), and central or abdominal obesity is considered a fundamental pathology for the MS. Many of the anthropometric and metabolic abnormalities of PCOS overlap with components of MS, and PCOS patients are at increased risk of having MS [ 7 ] . Adults with MS are at a greater risk of developing CVD [ 8 ] . PCOS women with MS may be at even greater risk for CVD because they
Materials and Methods