Waist-to-height ratio is a useful index for nonalcoholic fatty liver disease in children and adolescents: a secondary data analysis

Lin, Ming‐Shyan; Lin, Tsai-Hui; Guo, Shu‐Mei; Tsai, Ming-Horng; Chiang, Ming-Shin; Huang, Tung‐Jung; Chen, Mei‐Yen

doi:10.1186/s12889-017-4868-5

Cited by 43 publications

(42 citation statements)

References 30 publications

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“…Taller people, unlike obese people, might have a lower risk for cardiometabolic diseases [ 48 ]. Many studies revealed that there is a strong relationship between NAFLD and WHtR, and referred to WHtR as a useful parameter in predicting NAFLD [ 47 , 49 , 50 ].…”

Section: Discussionmentioning

confidence: 99%

The role of anthropometric indices in the prediction of non-alcoholic fatty liver disease in the PERSIAN Guilan Cohort study (PGCS)

Mansour-Ghanaei

Naghipour

et al. 2018

JMedLife

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Introduction: Non-alcoholic fatty liver disease (NAFLD) is an obesity-associated health problem that causes other liver diseases for the patient. Four anthropometric indices: body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) were analyzed as NAFLD predictors in the present study.Methods: From the total number of individuals who referred to the PERSIAN Guilan Cohort study (PGCS) located in the north of Iran during the period of study, a total of 960 people were enrolled in the present study. NAFLD was diagnosed using through an abdominal ultrasound exam. Height, weight, WC, BMI, WHR and WHtR were later calculated. Chi-square, ANOVA and logistic regression analyses were used to analyze the risk factors.Results: Out of the 960 individuals who were enrolled in the study, 597 (62.2%) were male and 363 (37.8%) were female (with an average age of 47.21 ± 7.29 years). There was a significant relationship between weight and NAFLD (P<0.001). There was also a significant relationship between BMI (OR= 8.41; 95% CI = 5.59–12.75), WC (OR= 2.67; 95% CI = 2.05–3.48), WHR (OR= 3.84; 95% CI = 2.26–6.52), WHtR (OR= 28.53; 95% CI = 6.94–117.31) and NAFLD (P<0.001). The results of the logistic regression analysis showed that WHtR, BMI and WC were effective predictors for the risk of NAFLD while WHtR played a more important role in the prediction of NAFLD.Conclusion: Anthropometric indices, especially WHtR, as a simple screening tool, seem to be an important criterion for the detection of NAFLD.

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Section: Discussionmentioning

confidence: 99%

The role of anthropometric indices in the prediction of non-alcoholic fatty liver disease in the PERSIAN Guilan Cohort study (PGCS)

Mansour-Ghanaei

Naghipour

et al. 2018

JMedLife

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“…Discrepancies in results can be explained by differences in baseline characteristics of the studied populations. These may also include ethnic differences: WCHR was originally proposed for a Taiwanese population [17] and HSI for a South Korean cohort [12]. Other differences include measurement techniques.…”

Section: Discussionmentioning

confidence: 99%

“…Magnetic resonance imaging (MRI)-based methods are expensive and not widely available; computed tomography and ultrasound have intrinsic subjective and technical limitations [9,10]; and the fatty liver index (FLI) [11], hepatic steatosis index (HSI) [12], and NAFLD liver fat score (NAFLD-LFS) [13] lack sufficient validation or cannot quantify steatosis accurately [10,13,14]. Waist circumference (WC) measurement has been found to be as reliable as FLI [15,16], and waist circumference/height ratio (WCHR) is reportedly more reliable than WC, although the latter conclusion is questionable [17,18]. So far, ultrasound remains the most accessible and frequently used screening diagnostic test [9], but insurance limitations in Russia reduce its availability [3].…”

Section: Introductionmentioning

confidence: 99%

A New, Non-Invasive Scale for Steatosis Developed Using Real-World Data From Russian Outpatients to Aid in the Diagnosis of Non-Alcoholic Fatty Liver Disease

Маев¹,

Самсонов²,

Лазебник³

et al. 2020

Adv Ther

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Introduction: The current non-invasive tools for the diagnosis of non-alcoholic fatty liver disease (NAFLD) have methodological limitations. We aimed to develop a non-invasive scale to assist in the diagnosis of NAFLD. To achieve our aim, we conducted a secondary analysis of data from a large observational study conducted in Russia. Methods: This retrospective analysis assessed the frequency of NAFLD in the population of patients in the DIREG_L_06725 study, an epidemiological, observational, cross-sectional, multicenter study performed in 50,145 outpatients from 16 Russian cities. Among the cohort of patients diagnosed with NAFLD, we identified factors associated with the risk of NAFLD. To develop a non-invasive tool for diagnosing NAFLD, we also determined the frequency of steatohepatitis. Results: Our analysis included 48,297 patients; NAFLD was present in 20,281 patients (42.0%). The majority (64.1%) were women (80.3% postmenopause), and 87% had a body mass index (BMI) [ 27.0 kg/m 2. We developed a fully noninvasive scale (St-index) that showed a specificity of 91.4% for ruling in steatosis, and a sensitivity of 93.8% for ruling out steatosis. Multivariate regression analyses conducted in the subgroups of patients aged C 12 and \ 18 years and those with BMI \ 25.0 kg/m 2 produced area under the receiver operating characteristic (AUROC) curve values of 0.8243 and 0.7054, respectively. The factors most strongly associated with the development of NAFLD were age [ 35 years, presence of type 2 diabetes mellitus, and a waist circumference/ height ratio [ 0.54. Conclusion: Our non-invasive steatosis scale, St-index, can help physicians diagnose NAFLD in high-risk patients in the absence of ultrasound data.

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“…A study was conducted by Lin MS et al 2017. 38 to establish the relation between waist to height ratio and NAFLD in children and adolescence. For their study they selected children of age 10 to 19 years old.…”

Section: Study Reports Related To the Risk Factors And Etiology Ofmentioning

confidence: 99%

A Recent Research on Non Alcoholic Fatty Liver Disease

2019

IJRTE

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Non alcoholic fatty liver disease (NAFLD) is a persistent condition of liver steatosis in the absence of alcohol consumption. The main risk factors associated with the disease are hypertension, diabetes mellitus and dyslipidemia these are together termed as metabolic syndrome. Recent studies identified that children are more vulnerable to develop NAFLD in future due to sedentary life styles and poor diet. NAFLD can further make complications of cardiovascular and liver related disorders. Apart from these causes there are factors such as enzyme, gene expression; amino acid regulation and so on in the human body plays an important role in the development of NAFLD. The objective of this research is to summaries the various ways by which a NAFLD is affected in a normal individual and to point out current research on treatment strategy for the NAFLD.

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Waist-to-height ratio is a useful index for nonalcoholic fatty liver disease in children and adolescents: a secondary data analysis

Cited by 43 publications

References 30 publications

The role of anthropometric indices in the prediction of non-alcoholic fatty liver disease in the PERSIAN Guilan Cohort study (PGCS)

The role of anthropometric indices in the prediction of non-alcoholic fatty liver disease in the PERSIAN Guilan Cohort study (PGCS)

A New, Non-Invasive Scale for Steatosis Developed Using Real-World Data From Russian Outpatients to Aid in the Diagnosis of Non-Alcoholic Fatty Liver Disease

A Recent Research on Non Alcoholic Fatty Liver Disease

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