“…As with most research designs, there are an infinite number of combinations of potentially confounding issues related to participant selection for the protocol, like age, sex, training status, health status, nutritional status, hormonal status, etc., but with blood flow restriction protocols, many other factors must also be considered. These additional factors could include the type of cuff used to induce the restriction pressure (width of the cuff, type of material, pneumatically controlled cuffs or tension wraps or bandages applied based on perceived discomfort; Loenneke et al, 2014c ; Buckner et al, 2017 ; Stray-Gundersen et al, 2020 ), initial pressure/tightness of the cuffs before inflation ( Karabulut et al, 2011a , 2014 ), the restrictive pressure used (absolute, relative, percent of total restrictive pressure, intermittent pressure, continuous pressure; Murray et al, 2020 ), the composition (fat and muscle mass; Karabulut et al, 2014 ) and size (circumference or girth) of the limb being restricted ( Loenneke et al, 2014a ), the mode of exercise (walking, cycling, resistance training, absolute loads, relative loads, contraction types – isometric, isotonic, isokinetic), the protocols used if exercise is required (number of repetitions, number of sets, muscle groups, cadence of the concentric and eccentric portions of the movement, time under tension), and if the responses are acute or due to prolonged training (how many sessions, days, weeks, etc.).…”