Wall shear stress quantification in the human conjunctival pre-capillary arterioles in vivo

Koutsiaris, Aristotle G.; Tachmitzi, Sophia V.; Batis, Nick

doi:10.1016/j.mvr.2012.11.003

Cited by 176 publications

(227 citation statements)

References 19 publications

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“…126 On the apical/luminal side brain endothelial cells are continuously exposed to a shear stress of 1 -10 N/cm 2 in capillaries. 199 Applying this level of shear stress to brain endothelial cells in vitro increases their barrier properties and the expression of tight junction components. 93,200,201 …”

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confidence: 99%

Apicobasal polarity of brain endothelial cells

Worzfeld

Schwaninger

2015

J Cereb Blood Flow Metab

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Normal brain homeostasis depends on the integrity of the blood-brain barrier that controls the access of nutrients, humoral factors, and immune cells to the CNS. The blood-brain barrier is composed mainly of brain endothelial cells. Forming the interface between two compartments, they are highly polarized. Apical/luminal and basolateral/abluminal membranes differ in their lipid and (glyco-)protein composition, allowing brain endothelial cells to secrete or transport soluble factors in a polarized manner and to maintain blood flow. Here, we summarize the basic concepts of apicobasal cell polarity in brain endothelial cells. To address potential molecular mechanisms underlying apicobasal polarity in brain endothelial cells, we draw on investigations in epithelial cells and discuss how polarity may go awry in neurological diseases.

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confidence: 99%

Apicobasal polarity of brain endothelial cells

Worzfeld

Schwaninger

2015

J Cereb Blood Flow Metab

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“…This velocity is physiological and comparable to the average cross-sectional velocities measured in the arterioles of the human conjunctiva (see for example the studies of Koutsiaris etal. [23,24]). The distribution of flow between the two daughter branches (flow split) was controlled by means of hydrostatic pressure difference by independently adjusting the height of the outlet reservoirs using micrometer stages.…”

Section: The Flow Systemmentioning

confidence: 99%

Red blood cell aggregate flux in a bifurcating microchannel

Kaliviotis

Pasias

Sherwood

et al. 2017

Medical Engineering & Physics

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Red blood cell aggregation plays a key role in microcirculatory flows, however, little is known about the transport characteristics of red blood cell aggregates in branching geometries. This work reports on the fluxes of red blood cell aggregates of various sizes in a T-shaped microchannel, aiming to clarify the effects of different flow conditions in the outlet branches of the channel. Image analysis techniques, were utilised, and moderately aggregating human red blood cell suspensions were tested in symmetric (~50-50%) and asymmetric flow splits through the two outlet (daughter) branches. The results revealed that the flux decreases with aggregate size in the inlet (parent) and daughter branches, mainly due to the fact that the number of larger structures is significantly smaller than that of smaller structures. However, when the flux in the daughter branches is examined relative to the aggregate size flux in the parent branch an increase with aggregate size is observed for a range of asymmetric flow splits. This increase is attributed to size distribution and local concentration changes in the daughter branches. The results show that the flow of larger aggregates is not suppressed downstream of a bifurcation, and that blood flow is maintained, for physiological levels of red blood cell aggregation.

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“…According to Poiseuille's law, small changes in the vessel radius will result in large changes in the resistance. Capillaries are the smallest blood vessels, and red blood cells with diameters of 7 m must deform to pass through them [2]. In the past, a capillary bed consisting of many individual capillary vessels in parallel has been widely accepted to have a very low overall resistance to flow, even though the resistance of a single capillary is relatively high.…”

Section: Introductionmentioning

confidence: 99%

Flow Resistance of Vessels with an Enlarged Total Cross-Sectional Area in the Midsection

Song

2013

TOCVJ

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To understand the hemodynamics of the microcirculation, we compared the resistance of vessels that either had an enlarged cross-sectional area in the midsection (denoted vessel 1) or had a uniform diameter (denoted vessel 2). The length of the two vessels and the pressure difference between the ends were equal. The two vessels were filled with water, and the volume of water flowing through the two vessels per second was measured. The volume of water flowing through vessel 1 was 4.05 ml/sec, and the volume of water flowing through vessel 2 was 4.37 ml/sec. Vessel 1 had a higher resistance, and water drained more slowly than from vessel 2. These results demonstrate that vessels with a greater crosssectional area in the midsection have a lower flow than vessels with a constant cross-section, even though resistance in the midsection is lower when the cross-sectional area is greater.

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Wall shear stress quantification in the human conjunctival pre-capillary arterioles in vivo

Cited by 176 publications

References 19 publications

Apicobasal polarity of brain endothelial cells

Apicobasal polarity of brain endothelial cells

Red blood cell aggregate flux in a bifurcating microchannel

Flow Resistance of Vessels with an Enlarged Total Cross-Sectional Area in the Midsection

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