Warfarin-Induced Necrosis of Skin

Lacy, Jerome P.; Goodin, Robert R.

doi:10.7326/0003-4819-82-3-381

Cited by 20 publications

(1 citation statement)

References 4 publications

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“…The syndrome of diffuse intravascular clotting can be excluded also because the laboratory studies do not support it, and no other bleeding sites are identified in the reported cases [11], None of the mechanisms discussed have been unequivocally proven to be the causes of the paradoxical appearance of the thrombotic vasculitis during administration of different anticoagulants of fibrinolytic agents which pro duced a similar clinical manifestation in our 6 cases and an identical histo logical picture in 5. The cause of vasculitis appears to be a toxic reaction to the initial high dose of the drug causing damage to the capillaries at the dermovascular loop.…”

Section: Discussionmentioning

confidence: 89%

Skin Petechiae and Ecchymoses (Vasculitis) Due to Anticoagulant Therapy

Stavorovsky¹,

Lichtenstein²,

Nissim³

1979

Dermatology

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The appearance of petechiae and ecchymoses following anticoagulant and fibrinolytic therapy is an unusual and rare complication. The mechanism of the vasculitis is obscure but may be related to a chemical vasotoxic reaction. During anticoagulant and fibrinolytic therapy, 6 patients developed petechiae and ecchymoses which was accompanied by pain and fever. There were no disturbances of blood clotting factors. In spite of the varied action of the different anticoagulants and fibrinolytic drugs, the clinical course and the histological examination demonstrated a similar identical vasculitis.

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Section: Discussionmentioning

confidence: 89%

Skin Petechiae and Ecchymoses (Vasculitis) Due to Anticoagulant Therapy

Stavorovsky¹,

Lichtenstein²,

Nissim³

1979

Dermatology

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Atypical Purpura Fulminans With Benign Monoclonal Gammopathy

Friedenberg¹

1978

Arch Dermatol

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Oral Anticoagulant Therapy—50 Years Later

Ansell¹

1993

Arch Intern Med

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The year 1991 marked the 50th anniversary of the first clinical use of oral anticoagulant therapy as a means of preventing thromboembolic disease. Despite long-term physician familiarity with oral anticoagulants, this mode of therapy still suffers from a relatively high-risk/safety profile. This review briefly highlights important historical and pharmacokinetic points of interest but focuses predominantly on aspects of the day-to-day management of anticoagulant therapy aiming to enhance physician performance in this therapeutic milieu. Emphasis is placed on therapeutic monitoring, understanding the prothrombin time, managing complications, and assessing future innovations for the management of a growing population of patients treated with orally administered anticoagulants.

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Warfarin-Induced Necrosis of Skin

Cited by 20 publications

References 4 publications

Skin Petechiae and Ecchymoses (Vasculitis) Due to Anticoagulant Therapy

Skin Petechiae and Ecchymoses (Vasculitis) Due to Anticoagulant Therapy

Atypical Purpura Fulminans With Benign Monoclonal Gammopathy

Oral Anticoagulant Therapy—50 Years Later

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