Warm autoimmune hemolytic anemia is an IgM–IgG immune complex disease

Stahl, Dulcelina A.; Sibrowski, W.

doi:10.1016/j.jaut.2005.08.003

Cited by 21 publications

(12 citation statements)

References 35 publications

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“…WAIHA is one of four clinical types of AIHA, characterized by the autoantibodies directing against patient's own antigens on RBCs with the best reactive temperatures at 37 °C and accounting for 50-70% of all AIHA patients [43]. It produces a variable anemia, i.e., mild and sometimes severe.…”

Section: Discussionmentioning

confidence: 99%

Warm Autoimmune Hemolytic Anemia: Clinical Profile and Management

Sudulagunta¹,

Kumbhat

Sodalagunta

et al. 2017

J Hematol

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Background: Autoimmune hemolytic anemia (AIHA) is a rare autoimmune disease in which autoantibodies target red blood cells leading to marked decrease in their lifespan. The classification of AIHA is based on the immunochemical properties of the RBC autoantibody. Warm antibody AIHA (wAIHA) accounts for 75-80% of all adult AIHA cases. The treatment of wAIHA is mainly corticosteroids. Our retrospective study aimed to study the clinical profile and management of wAIHA.

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Section: Discussionmentioning

confidence: 99%

Warm Autoimmune Hemolytic Anemia: Clinical Profile and Management

Sudulagunta¹,

Kumbhat

Sodalagunta

et al. 2017

J Hematol

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“…It is a rare disorder with an estimated incidence of one to three cases per 100,000 persons per year [1]. AIHA is classified as either warm (50-70%) [2,3] or cold AIHA, depending upon the temperature at which the autoantibodies show maximal binding. Warm AIHA (WAIHA) is mediated by warm reactive autoantibodies, which are usually of the immunoglobulin G class.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of rituximab in auto-immune hemolytic anemia: A meta-analysis of 21 studies

Reynaud

Durieu

Dutertre

et al. 2015

Autoimmunity Reviews

111

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“…Recent data indicate that altered IgM-IgG immune complexes are at the origin of such altered antibody repertoire of plasma IgM of WAIHA patients [132]. IgM in plasma of WAIHA patients exhibits a significantly increased binding affinity toward IgG purified from plasma of healthy individuals and eluted from the RBC surface of healthy individuals, compared to the binding affinity of IgM of healthy individuals ( fig.…”

Section: Warm Autoimmune Hemolytic Anemia Is An Igm-igg Immune Complementioning

confidence: 99%

“…Stahl RBC structures might be the autoantigen in WAIHA [132]. To identify the epitope specificity of IgM and IgG within the IgM-IgG immune complexes of WAIHA patients and to characterize the mechanism of immune complex-RBC interaction, is at the center of further investigations.…”

mentioning

confidence: 99%

“…A decreased frequency of IgM-IgG immune complexes in plasma has been demonstrated in patients with gastric cancer [144]. In WAIHA patients, IgG3 and IgG1 are actively enriched in IgM-IgG immune complexes, despite of a normal IgG subclass distribution in plasma (IgG 1 > IgG 3 > IgG 2 > IgG 4) [132]. The IgG subclass distribution in IgMIgG immune complexes of human plasma has not yet been systematically investigated.…”

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confidence: 99%

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Warm Autoimmune Hemolytic Anemia: A Clinical Model to Study Mechanisms of Immunoregulation*

Stahl

2006

Transfus Med Hemother

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The study of immune hemolytic anemias has contributed significantly to the understanding of the immune response in the human system in the past. Thus, the concept of receptor specificity - becoming the rationale of the clonal selection theory when trying to explain how the organism avoids autoaggression - has been developed originally upon the study of immune hemolytic anemias, and the question whether the antigen-antibody reaction is determined primarily by chemical or by physical aspects of interaction of molecules has been discussed originally taking immune hemolytic anemias as an example. Today, immunohematology still provides excellent models to study immune mechanisms that are of both clinical relevance and fundamental significance for the understanding of mechanisms that determine the appropriate recognition of self- and non-self-antigens in the context of complex dynamic interactions at the cellular and humoral level of the human immune system. The data summarized in this review focus on the aspects that the study of warm autoimmune hemolytic anemia may contribute to the understanding of immunoregulation in the human system.

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Warm autoimmune hemolytic anemia is an IgM–IgG immune complex disease

Cited by 21 publications

References 35 publications

Warm Autoimmune Hemolytic Anemia: Clinical Profile and Management

Warm Autoimmune Hemolytic Anemia: Clinical Profile and Management

Efficacy and safety of rituximab in auto-immune hemolytic anemia: A meta-analysis of 21 studies

Warm Autoimmune Hemolytic Anemia: A Clinical Model to Study Mechanisms of Immunoregulation*

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