Warthin Tumor–Like Mucoepidermoid Carcinoma

Heatley, Nicholas; Harrington, Kevin; Thway, Khin

doi:10.1177/1066896917724889

Cited by 22 publications

(34 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 2015, Ishibashi et al2 gave the first description of a Warthin-like variant of MEC. A similar histomorphology was also described by Heatley et al11 in a 17-year-old female presenting with a cystic lesion, which, on initial excision, resembled WT and classical mucoepidermoid morphology in the recurrent tumor. A retrospective review of the initial histology revealed the squamoid appearance and focal presence of mucin, which raised the suspicion of Warthin-like MEC.…”

Section: Discussionsupporting

confidence: 79%

Warthin-like mucoepidermoid carcinoma of the parotid gland: a diagnostic and therapeutic dilemma

Balasubiramaniyan¹,

Sultania²,

Sable³

et al. 2019

Autops. Case Rep.

View full text Add to dashboard Cite

Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor. Although the parotid gland is the most common site of involvement, other major salivary glands and the minor salivary glands—most commonly of the palate—also can be involved. The management of mucoepidermoid carcinoma depends on the grade of the tumor and the adequacy of resection. We present the case of a 56-year-old female presenting a painless progressive cheek mass over 2 months. Imaging and fine-needle aspiration cytology provided the diagnosis of Mucoepidermoid carcinoma. A superficial parotidectomy was done, and the histopathology revealed a predominantly cystic tumor with a bilayered epithelium of oncocytic and basal cells. Moderate nuclear pleomorphism with infiltration of atypical squamous cells in few glandular cysts was seen. Special staining revealed the presence of intracellular mucin. A diagnosis of Warthin-like variant of MEC was made, based on these findings. After the surgical procedures, the patient is disease-free at 8 months of follow-up. The Warthin-like variant is a rare variant of MEC with fewer than 10 cases described in the English literature. Various differential diagnoses include the malignant transformation of Wartin tumor (WT), squamous metaplasia of WT, and metastasis from a distant primary. We emphasize the role of routine microscopy in identifying rare variants of common malignancies. Even though translocation studies are helpful in diagnosis, the typical histopathological findings should confirm it.

show abstract

Section: Discussionsupporting

confidence: 79%

Warthin-like mucoepidermoid carcinoma of the parotid gland: a diagnostic and therapeutic dilemma

Balasubiramaniyan¹,

Sultania²,

Sable³

et al. 2019

Autops. Case Rep.

View full text Add to dashboard Cite

show abstract

“…Perplexingly, mucoid metaplasia may occur as well, which may easily lead to misdiagnosis of MEC [3]. However, metaplastic changes in WT are usually focal and admixed with necrosis, haemorrhages and fibrosis associated with prior biopsy [11]. On the other hand, Heatley et al described a case of Warthin-like MEC recurring after 4 years as obvious MEC [11].…”

Section: Discussionmentioning

confidence: 99%

“…However, metaplastic changes in WT are usually focal and admixed with necrosis, haemorrhages and fibrosis associated with prior biopsy [11]. On the other hand, Heatley et al described a case of Warthin-like MEC recurring after 4 years as obvious MEC [11]. Detailed evaluation of primary slides revealed a 1-mm distinctive area composed of small cysts lined by attenuated epithelial cells and mucous cells.…”

Section: Discussionmentioning

confidence: 99%

“…Only newly reported cases of MEC with Warthin-like morphology were included in the analysis; thus, 7 studies reporting 20 cases were included (Table 1 [8][9][10][11][12][13][14]). Similarly, the PubMed database was searched using "Warthin MAML2" and "Warthin t(11;19)" queries (performed on 6 February 2019); subsequently, the reference lists of the included studies were also searched for further articles.…”

Section: Literature Searchmentioning

confidence: 99%

“…Originally, García et al reported a series of 12 oncocytic MECs in 2011 [8]. Among these, 5 were described as having Warthin-like histology (all such cases reported to date are summarized in Table 1 [8][9][10][11][12][13][14]) and harboured a mastermindlike transcriptional coactivator 2 (MAML2) rearrangement. This alteration occurs in > 50% of MECs and correlates with low-/intermediate-grade histology and a better prognosis [15].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

MAML2 rearrangement as a useful diagnostic marker discriminating between Warthin tumour and Warthin-like mucoepidermoid carcinoma

et al. 2020

View full text Add to dashboard Cite

Warthin tumour is the second most common benign neoplasm of salivary glands. Despite its relatively characteristic histology, it may sometimes mimic other lesions. Here, we report two female non-smoker patients diagnosed with low-grade mucoepidermoid carcinoma with oncocytic epithelium and prominent lymphoid (Warthin-like) stroma and with molecularly confirmed MAML2 rearrangement. In addition, we screened a consecutive series of 114 Warthin tumour cases by means of MAML2 break apart fluorescence in situ hybridization to assess its value in differential diagnosis. MAML2 rearrangement was detected in both mucoepidermoid carcinoma cases, while all Warthin tumours were negative. Taking into account the literature data, Warthin-like mucoepidermoid carcinomas are more frequently observed in women, while a slight male predominance and smoking history are typical for Warthin tumour. In addition, the patients with Warthin-like mucoepidermoid carcinoma were significantly younger than those with Warthin tumour. To conclude, Warthin-like mucoepidermoid carcinoma may usually be suspected based on histology, while the diagnosis can be confirmed by means of molecular assays such as FISH. The investigation of MAML2 status is particularly advised when Warthin tumour is considered in a young, non-smoking, female patient.

show abstract

Pediatric Warthin-like Mucoepidermoid Carcinoma: Report of Two Cases with One Persistent/Recurrent as Conventional Mucoepidermoid Carcinoma

Daoud

McLean-Holden

Pfeifer

et al. 2020

Head and Neck Pathol

View full text Add to dashboard Cite

Warthin Tumor–Like Mucoepidermoid Carcinoma

Cited by 22 publications

References 3 publications

Warthin-like mucoepidermoid carcinoma of the parotid gland: a diagnostic and therapeutic dilemma

Warthin-like mucoepidermoid carcinoma of the parotid gland: a diagnostic and therapeutic dilemma

MAML2 rearrangement as a useful diagnostic marker discriminating between Warthin tumour and Warthin-like mucoepidermoid carcinoma

Pediatric Warthin-like Mucoepidermoid Carcinoma: Report of Two Cases with One Persistent/Recurrent as Conventional Mucoepidermoid Carcinoma

Contact Info

Product

Resources

About