Waste-Minimized Protocol for the Synthesis of Sulfonylated N-Heteroaromatics in Water

Abstract

An ecofriendly and practical method for the efficient synthesis of various sulfonylated N-heteroaromatics in water under metal-free, organic-solvent-free, neutral, and mild reaction conditions was developed. The employment of readily available reagents, wide substrate scope, high chemoselectivity, and regioselectivity make this protocol very practical. Importantly, the pure products can be easily obtained via filtration and washing by alcohol without extraction and recrystallization.

Recent Progress and Emerging Technologies towards a Sustainable Synthesis of Sulfones

“…[38] He and co-workers described a waste-minimized one-pot protocol for the synthesis of sulfonylated pyridines and quinolines (Scheme 10). [39] In this method, the necessary sulfinic acid salts are generated in situ from the corresponding sulfonyl chlorides and Na 2 SO 3 . As sulfinates are mostly prepared from sulfonyl chlorides anyway, this process obviates a time-and resource-consuming additional step.…”

“…Synthesis of sulfonylated N-heteroaromatics in water. [39] Scheme 11. Synthesis of quinoline-N-oxides in water.…”

Synthetic applications of flavin photocatalysis: a review

“…In recent years, both academia and industry [1][2][3][4][5][6][7][8][9][10] have attracted extensive interest in the context of green and sustainable chemistry due to the development of clean, economical and efficient chemical processes. Over the last decade, visible light photocatalysis has evolved into a widely used method in organic syntheses as it is the most sustainable reaction inducer and has been increasingly used as a powerful strategy to promote numerous synthetic transformations in organic chemistry 11 as it is a safe, renewable, and inexpensive source of chemical energy.…”

KI-catalyzed synthesis of S-Thiocarbamates by cross-coupling of cyclohexyl isocyanide with sulfonyl chlorides

“…Sulfonyl chlorides are readily available and have been widely used in the fields of materials science as well as in organic and medicinal syntheses. [18][19][20][21] Nonetheless, there is no example of the direct generation of S-Thiocarbamates from sulfonyl chlorides. On the contrary, methods based on metal iodide catalysis have gained significant attention in recent years because these processes are environmentally friendly and economical.…”